Restoring Fertility with Cryopreserved Prepubertal Testicular Tissue: Perspectives with Hydrogel Encapsulation, Nanotechnology, and Bioengineered Scaffolds.
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| Title: | Restoring Fertility with Cryopreserved Prepubertal Testicular Tissue: Perspectives with Hydrogel Encapsulation, Nanotechnology, and Bioengineered Scaffolds. |
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| Authors: | Vermeulen, Maxime1, Poels, Jonathan, Michele, Francesca, Rieux, Anne, Wyns, Christine christine.wyns@uclouvain.be |
| Source: | Annals of Biomedical Engineering. Jul2017, Vol. 45 Issue 7, p1770-1781. 12p. |
| Subjects: | Childhood cancer, Fertility, Spermatozoa, Stem cells, Cryopreservation of organs, tissues, etc. |
| Abstract: | New and improved oncological therapies are now able to cure more than 80% of cancer-affected children in Europe. However, such treatments are gonadotoxic and result in fertility issues, especially in boys who are not able to provide a sperm sample before starting chemo/radiotherapy because of their prepubertal state. For these boys, cryopreservation of immature testicular tissue (ITT) is the only available option, aiming to preserve spermatogonial stem cells (SSCs). Both slow-freezing and vitrification have been investigated to this end and are now applied in a clinical setting for SSC cryopreservation. Research now has to focus on methods that will allow fertility restoration. This review discusses different studies that have been conducted on ITT transplantation, including those using growth factor supplementation like free molecules, or tissue encapsulation with or without nanoparticles, as well as the possibility of developing a bioartificial testis that can be used for in vitro gamete production or in vivo transplantation. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 123821236 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Restoring Fertility with Cryopreserved Prepubertal Testicular Tissue: Perspectives with Hydrogel Encapsulation, Nanotechnology, and Bioengineered Scaffolds. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vermeulen%2C+Maxime%22">Vermeulen, Maxime</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Poels%2C+Jonathan%22">Poels, Jonathan</searchLink><br /><searchLink fieldCode="AR" term="%22Michele%2C+Francesca%22">Michele, Francesca</searchLink><br /><searchLink fieldCode="AR" term="%22Rieux%2C+Anne%22">Rieux, Anne</searchLink><br /><searchLink fieldCode="AR" term="%22Wyns%2C+Christine%22">Wyns, Christine</searchLink><i> christine.wyns@uclouvain.be</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jul2017, Vol. 45 Issue 7, p1770-1781. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Childhood+cancer%22">Childhood cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Fertility%22">Fertility</searchLink><br /><searchLink fieldCode="DE" term="%22Spermatozoa%22">Spermatozoa</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cryopreservation+of+organs%2C+tissues%2C+etc%2E%22">Cryopreservation of organs, tissues, etc.</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: New and improved oncological therapies are now able to cure more than 80% of cancer-affected children in Europe. However, such treatments are gonadotoxic and result in fertility issues, especially in boys who are not able to provide a sperm sample before starting chemo/radiotherapy because of their prepubertal state. For these boys, cryopreservation of immature testicular tissue (ITT) is the only available option, aiming to preserve spermatogonial stem cells (SSCs). Both slow-freezing and vitrification have been investigated to this end and are now applied in a clinical setting for SSC cryopreservation. Research now has to focus on methods that will allow fertility restoration. This review discusses different studies that have been conducted on ITT transplantation, including those using growth factor supplementation like free molecules, or tissue encapsulation with or without nanoparticles, as well as the possibility of developing a bioartificial testis that can be used for in vitro gamete production or in vivo transplantation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-017-1789-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1770 Subjects: – SubjectFull: Childhood cancer Type: general – SubjectFull: Fertility Type: general – SubjectFull: Spermatozoa Type: general – SubjectFull: Stem cells Type: general – SubjectFull: Cryopreservation of organs, tissues, etc. Type: general Titles: – TitleFull: Restoring Fertility with Cryopreserved Prepubertal Testicular Tissue: Perspectives with Hydrogel Encapsulation, Nanotechnology, and Bioengineered Scaffolds. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vermeulen, Maxime – PersonEntity: Name: NameFull: Poels, Jonathan – PersonEntity: Name: NameFull: Michele, Francesca – PersonEntity: Name: NameFull: Rieux, Anne – PersonEntity: Name: NameFull: Wyns, Christine IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 45 – Type: issue Value: 7 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
| ResultId | 1 |
