View in EDS PDF Full Text

A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.

Saved in:
Bibliographic Details
Title: A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.
Authors: Cóndor, M.1 mcondor@unizar.es, García-Aznar, J.1 jmgaraz@unizar.es
Source: Biomechanics & Modeling in Mechanobiology. Aug2017, Vol. 16 Issue 4, p1207-1224. 18p.
Subjects: Cell-matrix adhesions, Computer simulation, Finite element method, Extracellular matrix, Biomechanics
Abstract: Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact, adherent cells can generate physical forces that are transmitted to the surrounding matrix, regulating the formation of cell-matrix adhesions. The main purpose of this work is to develop a computational model to simulate the dynamics of cell-matrix adhesions through a cohesive formulation within the framework of the finite element method and based on the principles of continuum damage mechanics. This model enables the simulation of the mechanical adhesion between cell and extracellular matrix (ECM) as regulated by local multidirectional forces and thus predicts the onset and growth of the adhesion. In addition, this numerical approach allows the simulation of the cell as a whole, as it models the complete mechanical interaction between cell and ECM. As a result, we can investigate and quantify how different mechanical conditions in the cell (e.g., contractile forces, actin cytoskeletal properties) or in the ECM (e.g., stiffness, external forces) can regulate the dynamics of cell-matrix adhesions. [ABSTRACT FROM AUTHOR]
Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 124133524
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Cóndor%2C+M%2E%22">Cóndor, M.</searchLink><relatesTo>1</relatesTo><i> mcondor@unizar.es</i><br /><searchLink fieldCode="AR" term="%22García-Aznar%2C+J%2E%22">García-Aznar, J.</searchLink><relatesTo>1</relatesTo><i> jmgaraz@unizar.es</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Aug2017, Vol. 16 Issue 4, p1207-1224. 18p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cell-matrix+adhesions%22">Cell-matrix adhesions</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+simulation%22">Computer simulation</searchLink><br /><searchLink fieldCode="DE" term="%22Finite+element+method%22">Finite element method</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact, adherent cells can generate physical forces that are transmitted to the surrounding matrix, regulating the formation of cell-matrix adhesions. The main purpose of this work is to develop a computational model to simulate the dynamics of cell-matrix adhesions through a cohesive formulation within the framework of the finite element method and based on the principles of continuum damage mechanics. This model enables the simulation of the mechanical adhesion between cell and extracellular matrix (ECM) as regulated by local multidirectional forces and thus predicts the onset and growth of the adhesion. In addition, this numerical approach allows the simulation of the cell as a whole, as it models the complete mechanical interaction between cell and ECM. As a result, we can investigate and quantify how different mechanical conditions in the cell (e.g., contractile forces, actin cytoskeletal properties) or in the ECM (e.g., stiffness, external forces) can regulate the dynamics of cell-matrix adhesions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=124133524
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10237-017-0883-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 1207
    Subjects:
      – SubjectFull: Cell-matrix adhesions
        Type: general
      – SubjectFull: Computer simulation
        Type: general
      – SubjectFull: Finite element method
        Type: general
      – SubjectFull: Extracellular matrix
        Type: general
      – SubjectFull: Biomechanics
        Type: general
    Titles:
      – TitleFull: A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Cóndor, M.
      – PersonEntity:
          Name:
            NameFull: García-Aznar, J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 16177959
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Biomechanics & Modeling in Mechanobiology
              Type: main
ResultId 1