Bibliographic Details
| Title: |
Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability. |
| Authors: |
Park, Chun Gwon1, Huh, Beom Kang2, Kim, Se-Na2, Lee, Seung Ho1, Hong, Hye Rim3, Choy, Young Bin1,2,3 ybchoy@snu.ac.kr |
| Source: |
Journal of Industrial & Engineering Chemistry. Oct2017, Vol. 54, p262-269. 8p. |
| Subjects: |
Nanostructured materials, Oral medication, Bioavailability, Gastrointestinal system, Losartan |
| Abstract: |
To enhance oral drug bioavailability, we propose mucoadhesive, nanostructured microparticles (PLGA/PEG NM) as a drug-delivery vehicle. The PLGA/PEG NM herein retain nanofibrous structures within microparticles, and possess a seven-fold increase in specific surface area than conventional spherical microparticles, allowing for synergistic improvement of a mucoadhesive property. In vivo evaluations demonstrated that PLGA/PEG NM showed prolonged retention in the gastrointestinal tract, as compared to control microparticles. When PLGA/PEG NM was loaded with losartan, an oral anti-hypertension drug, drug’s bioavailability increased by two-fold in comparison to a bolus losartan solution. Therefore, the PLGA/PEG NM are a promising carrier for oral drug delivery. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
