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Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability.

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Title: Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability.
Authors: Park, Chun Gwon1, Huh, Beom Kang2, Kim, Se-Na2, Lee, Seung Ho1, Hong, Hye Rim3, Choy, Young Bin1,2,3 ybchoy@snu.ac.kr
Source: Journal of Industrial & Engineering Chemistry. Oct2017, Vol. 54, p262-269. 8p.
Subjects: Nanostructured materials, Oral medication, Bioavailability, Gastrointestinal system, Losartan
Abstract: To enhance oral drug bioavailability, we propose mucoadhesive, nanostructured microparticles (PLGA/PEG NM) as a drug-delivery vehicle. The PLGA/PEG NM herein retain nanofibrous structures within microparticles, and possess a seven-fold increase in specific surface area than conventional spherical microparticles, allowing for synergistic improvement of a mucoadhesive property. In vivo evaluations demonstrated that PLGA/PEG NM showed prolonged retention in the gastrointestinal tract, as compared to control microparticles. When PLGA/PEG NM was loaded with losartan, an oral anti-hypertension drug, drug’s bioavailability increased by two-fold in comparison to a bolus losartan solution. Therefore, the PLGA/PEG NM are a promising carrier for oral drug delivery. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Industrial & Engineering Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 124269948
AccessLevel: 6
PubType: Periodical
PubTypeId: serialPeriodical
PreciseRelevancyScore: 0
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  Data: Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability.
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  Data: <searchLink fieldCode="AR" term="%22Park%2C+Chun+Gwon%22">Park, Chun Gwon</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Huh%2C+Beom+Kang%22">Huh, Beom Kang</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Se-Na%22">Kim, Se-Na</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Seung+Ho%22">Lee, Seung Ho</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hong%2C+Hye+Rim%22">Hong, Hye Rim</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Choy%2C+Young+Bin%22">Choy, Young Bin</searchLink><relatesTo>1,2,3</relatesTo><i> ybchoy@snu.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Industrial+%26+Engineering+Chemistry%22">Journal of Industrial & Engineering Chemistry</searchLink>. Oct2017, Vol. 54, p262-269. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Nanostructured+materials%22">Nanostructured materials</searchLink><br /><searchLink fieldCode="DE" term="%22Oral+medication%22">Oral medication</searchLink><br /><searchLink fieldCode="DE" term="%22Bioavailability%22">Bioavailability</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+system%22">Gastrointestinal system</searchLink><br /><searchLink fieldCode="DE" term="%22Losartan%22">Losartan</searchLink>
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  Label: Abstract
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  Data: To enhance oral drug bioavailability, we propose mucoadhesive, nanostructured microparticles (PLGA/PEG NM) as a drug-delivery vehicle. The PLGA/PEG NM herein retain nanofibrous structures within microparticles, and possess a seven-fold increase in specific surface area than conventional spherical microparticles, allowing for synergistic improvement of a mucoadhesive property. In vivo evaluations demonstrated that PLGA/PEG NM showed prolonged retention in the gastrointestinal tract, as compared to control microparticles. When PLGA/PEG NM was loaded with losartan, an oral anti-hypertension drug, drug’s bioavailability increased by two-fold in comparison to a bolus losartan solution. Therefore, the PLGA/PEG NM are a promising carrier for oral drug delivery. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Journal of Industrial & Engineering Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.jiec.2017.06.001
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 262
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      – SubjectFull: Nanostructured materials
        Type: general
      – SubjectFull: Oral medication
        Type: general
      – SubjectFull: Bioavailability
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      – SubjectFull: Gastrointestinal system
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      – SubjectFull: Losartan
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              Text: Oct2017
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