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The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria.

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Title: The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria.
Authors: Xiang, Xun1, Zhang, Bo-Rui1, Gao, Tao1, Zhao, Jie1, Ma, Long1, Jiang, Feng-Lei1, Wu, Can1,2, Liu, Yi1,3
Source: Chemosphere. Oct2017, Vol. 184, p1108-1116. 9p.
Subjects: Ligands (Chemistry), Mitochondria, Permeability measurement, Quantum dots, Toxicity testing
Abstract: The potential toxicity of Quantum dots (QDs) should be assessed comprehensively for their fast spreading applications. Many studies have shown the toxicity of QDs is associated with their surface ligands. In this work, two analog ligands with one carbon difference, 2-mercaptoacetic acid (TGA) and 3-mercaptopropionic acid (MPA) were used as coating materials in the syntheses of two types of CdTe QDs with similar physicochemical properties. Then the biological effects of QDs on isolated mitochondria were studied. It was found that the two types of QDs could impair mitochondrial respiration and induce mitochondrial permeability transition (MPT). However, as compared with TGA-CdTe QDs, MPA-CdTe QDs had a stronger effect on MPT. The weaker effect of TGA-CdTe QDs on MPT might be owing to their better stability and thus less amount of released Cd 2+ , which could be further explained by the stronger affinity between the ligand (TGA) and the cadmium complexes in the crystal growth of QDs. These results highlighted the importance of ligands responsible for the toxicity of QDs at the sub-cellular level. [ABSTRACT FROM AUTHOR]
Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 124271202
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria.
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  Data: <searchLink fieldCode="AR" term="%22Xiang%2C+Xun%22">Xiang, Xun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bo-Rui%22">Zhang, Bo-Rui</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gao%2C+Tao%22">Gao, Tao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Jie%22">Zhao, Jie</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ma%2C+Long%22">Ma, Long</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jiang%2C+Feng-Lei%22">Jiang, Feng-Lei</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wu%2C+Can%22">Wu, Can</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Liu%2C+Yi%22">Liu, Yi</searchLink><relatesTo>1,3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Chemosphere%22">Chemosphere</searchLink>. Oct2017, Vol. 184, p1108-1116. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Ligands+%28Chemistry%29%22">Ligands (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondria%22">Mitochondria</searchLink><br /><searchLink fieldCode="DE" term="%22Permeability+measurement%22">Permeability measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Quantum+dots%22">Quantum dots</searchLink><br /><searchLink fieldCode="DE" term="%22Toxicity+testing%22">Toxicity testing</searchLink>
– Name: Abstract
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  Data: The potential toxicity of Quantum dots (QDs) should be assessed comprehensively for their fast spreading applications. Many studies have shown the toxicity of QDs is associated with their surface ligands. In this work, two analog ligands with one carbon difference, 2-mercaptoacetic acid (TGA) and 3-mercaptopropionic acid (MPA) were used as coating materials in the syntheses of two types of CdTe QDs with similar physicochemical properties. Then the biological effects of QDs on isolated mitochondria were studied. It was found that the two types of QDs could impair mitochondrial respiration and induce mitochondrial permeability transition (MPT). However, as compared with TGA-CdTe QDs, MPA-CdTe QDs had a stronger effect on MPT. The weaker effect of TGA-CdTe QDs on MPT might be owing to their better stability and thus less amount of released Cd 2+ , which could be further explained by the stronger affinity between the ligand (TGA) and the cadmium complexes in the crystal growth of QDs. These results highlighted the importance of ligands responsible for the toxicity of QDs at the sub-cellular level. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
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      – Type: doi
        Value: 10.1016/j.chemosphere.2017.06.091
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 1108
    Subjects:
      – SubjectFull: Ligands (Chemistry)
        Type: general
      – SubjectFull: Mitochondria
        Type: general
      – SubjectFull: Permeability measurement
        Type: general
      – SubjectFull: Quantum dots
        Type: general
      – SubjectFull: Toxicity testing
        Type: general
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      – TitleFull: The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria.
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            NameFull: Xiang, Xun
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            NameFull: Zhang, Bo-Rui
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            NameFull: Gao, Tao
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            NameFull: Zhao, Jie
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            NameFull: Ma, Long
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            NameFull: Jiang, Feng-Lei
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              M: 10
              Text: Oct2017
              Type: published
              Y: 2017
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              Value: 184
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