The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels.
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| Title: | The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels. |
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| Authors: | Ou, Xiaomin doctorou1012@163.com, Miao, Yibing miaoyibing@gmail.com, Wang, Xiaoshen ruijin702@163.com, Ding, Jianhui1 Dingjianhui69@sina.com, He, Xiayun donganlu270hao@gmail.com, Hu, Chaosu hucsu62@163.com |
| Source: | Radiation Oncology. 8/18/2017, Vol. 12 Issue 1, p1-11. 11p. |
| Subjects: | Lymph node diseases, Metastasis, Chi-squared test, Nasopharynx cancer, Multivariate analysis, Prevention, Cancer-related mortality, Cancer radiotherapy, Cancer, Lymph nodes, Nasopharynx tumors, Prognosis, Radiotherapy, Pilot projects, Proportional hazards models, Retrospective studies, Kaplan-Meier estimator |
| Abstract: | |
| Copyright of Radiation Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 124727182 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ou%2C+Xiaomin%22">Ou, Xiaomin</searchLink><i> doctorou1012@163.com</i><br /><searchLink fieldCode="AR" term="%22Miao%2C+Yibing%22">Miao, Yibing</searchLink><i> miaoyibing@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Xiaoshen%22">Wang, Xiaoshen</searchLink><i> ruijin702@163.com</i><br /><searchLink fieldCode="AR" term="%22Ding%2C+Jianhui%22">Ding, Jianhui</searchLink><relatesTo>1</relatesTo><i> Dingjianhui69@sina.com</i><br /><searchLink fieldCode="AR" term="%22He%2C+Xiayun%22">He, Xiayun</searchLink><i> donganlu270hao@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Hu%2C+Chaosu%22">Hu, Chaosu</searchLink><i> hucsu62@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiation+Oncology%22">Radiation Oncology</searchLink>. 8/18/2017, Vol. 12 Issue 1, p1-11. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lymph+node+diseases%22">Lymph node diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Metastasis%22">Metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Nasopharynx+cancer%22">Nasopharynx cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer-related+mortality%22">Cancer-related mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Lymph+nodes%22">Lymph nodes</searchLink><br /><searchLink fieldCode="DE" term="%22Nasopharynx+tumors%22">Nasopharynx tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Kaplan-Meier+estimator%22">Kaplan-Meier estimator</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: <bold>Background: </bold>Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irradiation to level IB in the low-risk subgroups in NPC.<bold>Methods: </bold>This retrospective study identified 532 patients with NPC treated by definitive radiation in our institution from 2009 to 2010. Level IB nodes were electively irradiated based on the physician's decision. Diagnostic head and neck MRIs were reviewed. The involvements of nodal levels were evaluated according to 2013 updated guidelines of RTOG. The correlations of level IB metastasis and other factors were studied using Chi-square test and logistic regression model. Log-rank tests were used to compare survival rates. Cox proportional-hazards models were used to evaluate the effect of various factors. Patient-reported xerostomia was recoded in every follow-up and the extents of delayed xerostomia at 1 year post-radiation were compared between those with/without elective level IB irradiation.<bold>Results: </bold>N stage, bilateral nodal metastasis, level II involvement, level IIA involvement, level IIA with multiple levels involvement, maximal axial diameter (MAD) of level IIA nodes > 20 mm, MAD of neck lymph nodes > 30 mm, necrosis of level IIA nodes, extracapsular spread of level IIA correlated with level IB metastasis by univariate analysis. In multivariate analysis (MVA), bilateral nodal involvement, MAD of level IIA nodes > 20 mm or extracapsular spread of level IIA nodes, were independent predictive factors for level IB metastasis. Patients without either these factors were denoted low-risk group and the rest high-risk group. Of the low-risk group, there was no significant difference of regional control and overall survival (OS) between those with or without elective irradiation. The percentage of level IB recurrence of those without elective irradiation was 0.46%. Elective level IB irradiation was not significant upon MVA both for regional control and OS. Of the high-risk group, elective level IB irradiation was marginal significant for regional control, but not for OS upon MVA. No regional recurrence located at level IB. Overall, omission of elective irradiation to level IB reduced the mean doses of submandibular glands, but did not improve patient-reported xerostomia.<bold>Conclusion: </bold>For patients without high-risk factors of level IB metastasis, omission of elective level IB irradiation did not impair regional control and OS in NPC. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiation Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13014-017-0869-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: Lymph node diseases Type: general – SubjectFull: Metastasis Type: general – SubjectFull: Chi-squared test Type: general – SubjectFull: Nasopharynx cancer Type: general – SubjectFull: Multivariate analysis Type: general – SubjectFull: Prevention Type: general – SubjectFull: Cancer-related mortality Type: general – SubjectFull: Cancer radiotherapy Type: general – SubjectFull: Cancer Type: general – SubjectFull: Lymph nodes Type: general – SubjectFull: Nasopharynx tumors Type: general – SubjectFull: Prognosis Type: general – SubjectFull: Radiotherapy Type: general – SubjectFull: Pilot projects Type: general – SubjectFull: Proportional hazards models Type: general – SubjectFull: Retrospective studies Type: general – SubjectFull: Kaplan-Meier estimator Type: general Titles: – TitleFull: The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ou, Xiaomin – PersonEntity: Name: NameFull: Miao, Yibing – PersonEntity: Name: NameFull: Wang, Xiaoshen – PersonEntity: Name: NameFull: Ding, Jianhui – PersonEntity: Name: NameFull: He, Xiayun – PersonEntity: Name: NameFull: Hu, Chaosu IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 08 Text: 8/18/2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 1748717X Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: Radiation Oncology Type: main |
| ResultId | 1 |
