Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field.
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| Title: | Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field. |
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| Authors: | Alphandéry, Edouard1,2 edouardalphandery@hotmail.com, Idbaih, Ahmed3,4, Adam, Clovis5, Delattre, Jean-Yves3,4, Schmitt, Charlotte3,4, Guyot, François1, Chebbi, Imène2 |
| Source: | Journal of Controlled Release. Sep2017, Vol. 262, p259-272. 14p. |
| Subjects: | Magnetosomes, Controlled release drugs, Endotoxins, Magnetic fields, Thermotherapy, Nanoparticles |
| Abstract: | Previous studies showed that magnetic hyperthermia could efficiently destroy tumors both preclinically and clinically, especially glioma. However, antitumor efficacy remained suboptimal and therefore required further improvements. Here, we introduce a new type of nanoparticles synthesized by magnetotactic bacteria, called magnetosomes, with improved properties compared with commonly used chemically synthesized nanoparticles. Indeed, mice bearing intracranial U87-Luc glioma tumors injected with 13 μg of nanoparticles per mm 3 of tumor followed by 12 to 15 of 30 min alternating magnetic field applications displayed either full tumor disappearance in 40% of mice or no tumor regression using magnetosomes or chemically synthesized nanoparticles, respectively. Magnetosome superior antitumor activity could be explained both by a larger production of heat and by endotoxins release under alternating magnetic field application. Most interestingly, this behavior was observed when magnetosomes occupied only 10% of the whole tumor volume, which suggests that an indirect mechanism, such as an immune reaction, takes part in tumor regression. This is desired for the treatment of infiltrating tumors, such as glioma, for which whole tumor coverage by nanoparticles can hardly be achieved. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 125175686 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alphandéry%2C+Edouard%22">Alphandéry, Edouard</searchLink><relatesTo>1,2</relatesTo><i> edouardalphandery@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Idbaih%2C+Ahmed%22">Idbaih, Ahmed</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Adam%2C+Clovis%22">Adam, Clovis</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Delattre%2C+Jean-Yves%22">Delattre, Jean-Yves</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Schmitt%2C+Charlotte%22">Schmitt, Charlotte</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Guyot%2C+François%22">Guyot, François</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chebbi%2C+Imène%22">Chebbi, Imène</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Sep2017, Vol. 262, p259-272. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetosomes%22">Magnetosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Endotoxins%22">Endotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+fields%22">Magnetic fields</searchLink><br /><searchLink fieldCode="DE" term="%22Thermotherapy%22">Thermotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Previous studies showed that magnetic hyperthermia could efficiently destroy tumors both preclinically and clinically, especially glioma. However, antitumor efficacy remained suboptimal and therefore required further improvements. Here, we introduce a new type of nanoparticles synthesized by magnetotactic bacteria, called magnetosomes, with improved properties compared with commonly used chemically synthesized nanoparticles. Indeed, mice bearing intracranial U87-Luc glioma tumors injected with 13 μg of nanoparticles per mm 3 of tumor followed by 12 to 15 of 30 min alternating magnetic field applications displayed either full tumor disappearance in 40% of mice or no tumor regression using magnetosomes or chemically synthesized nanoparticles, respectively. Magnetosome superior antitumor activity could be explained both by a larger production of heat and by endotoxins release under alternating magnetic field application. Most interestingly, this behavior was observed when magnetosomes occupied only 10% of the whole tumor volume, which suggests that an indirect mechanism, such as an immune reaction, takes part in tumor regression. This is desired for the treatment of infiltrating tumors, such as glioma, for which whole tumor coverage by nanoparticles can hardly be achieved. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jconrel.2017.07.020 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 259 Subjects: – SubjectFull: Magnetosomes Type: general – SubjectFull: Controlled release drugs Type: general – SubjectFull: Endotoxins Type: general – SubjectFull: Magnetic fields Type: general – SubjectFull: Thermotherapy Type: general – SubjectFull: Nanoparticles Type: general Titles: – TitleFull: Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alphandéry, Edouard – PersonEntity: Name: NameFull: Idbaih, Ahmed – PersonEntity: Name: NameFull: Adam, Clovis – PersonEntity: Name: NameFull: Delattre, Jean-Yves – PersonEntity: Name: NameFull: Schmitt, Charlotte – PersonEntity: Name: NameFull: Guyot, François – PersonEntity: Name: NameFull: Chebbi, Imène IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 09 Text: Sep2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 01683659 Numbering: – Type: volume Value: 262 Titles: – TitleFull: Journal of Controlled Release Type: main |
| ResultId | 1 |
