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Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.

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Title: Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.
Authors: Dave, Jaydev K.1 jaydev.dave@jefferson.edu, Kulkarni, Sushmita V.1,2, Pangaonkar, Purva P.1,3, Stanczak, Maria1, Mcdonald, Maureen E.4, Cohen, Ira S.5, Mehrotra, Praveen5, Savage, Michael P.5, Walinsky, Paul5, Iiruggiero, Nicholas J.5, Fischman, David L.5, Ogilby, David5, Vanwhy, Carolyn5, Lombardi, Matthew5, Forsberg, Flemming1, Ruggiero, Nicholas J 2nd5 (AUTHOR)
Source: Ultrasound in Medicine & Biology. Nov2017, Vol. 43 Issue 11, p2718-2724. 7p.
Subjects: Cardiac catheterization, Ultrasound contrast media, Noninvasive diagnostic tests, Systolic blood pressure, Cardiovascular disease diagnosis, Blood pressure measurement, Diagnostic imaging, Fluorocarbons, Heart ventricles, Research funding, Signal processing, Sound, Ultrasonic imaging, Equipment & supplies, Contrast media, Physiology
Abstract: This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2.5-MHz transmit frequency. Radiofrequency data were processed and subharmonic amplitudes were compared with the pressure catheter data. The correlation coefficient between subharmonic signals and pressure catheter data ranged from -0.3 to -0.9. For acquisitions with optimum acoustic output, pressure errors between the subharmonic technique and catheter were as low as 2.6 mmHg. However, automatically determining optimum acoustic output during scanning for each patient remains to be addressed before clinical applicability can be decided. [ABSTRACT FROM AUTHOR]
Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 125195174
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.
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  Data: <searchLink fieldCode="AR" term="%22Dave%2C+Jaydev+K%2E%22">Dave, Jaydev K.</searchLink><relatesTo>1</relatesTo><i> jaydev.dave@jefferson.edu</i><br /><searchLink fieldCode="AR" term="%22Kulkarni%2C+Sushmita+V%2E%22">Kulkarni, Sushmita V.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pangaonkar%2C+Purva+P%2E%22">Pangaonkar, Purva P.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Stanczak%2C+Maria%22">Stanczak, Maria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mcdonald%2C+Maureen+E%2E%22">Mcdonald, Maureen E.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cohen%2C+Ira+S%2E%22">Cohen, Ira S.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Mehrotra%2C+Praveen%22">Mehrotra, Praveen</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Savage%2C+Michael+P%2E%22">Savage, Michael P.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Walinsky%2C+Paul%22">Walinsky, Paul</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Iiruggiero%2C+Nicholas+J%2E%22">Iiruggiero, Nicholas J.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Fischman%2C+David+L%2E%22">Fischman, David L.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Ogilby%2C+David%22">Ogilby, David</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Vanwhy%2C+Carolyn%22">Vanwhy, Carolyn</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Lombardi%2C+Matthew%22">Lombardi, Matthew</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Forsberg%2C+Flemming%22">Forsberg, Flemming</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ruggiero%2C+Nicholas+J+2nd%22">Ruggiero, Nicholas J 2nd</searchLink><relatesTo>5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Ultrasound+in+Medicine+%26+Biology%22">Ultrasound in Medicine & Biology</searchLink>. Nov2017, Vol. 43 Issue 11, p2718-2724. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Cardiac+catheterization%22">Cardiac catheterization</searchLink><br /><searchLink fieldCode="DE" term="%22Ultrasound+contrast+media%22">Ultrasound contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Noninvasive+diagnostic+tests%22">Noninvasive diagnostic tests</searchLink><br /><searchLink fieldCode="DE" term="%22Systolic+blood+pressure%22">Systolic blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+disease+diagnosis%22">Cardiovascular disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure+measurement%22">Blood pressure measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorocarbons%22">Fluorocarbons</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+ventricles%22">Heart ventricles</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Signal+processing%22">Signal processing</searchLink><br /><searchLink fieldCode="DE" term="%22Sound%22">Sound</searchLink><br /><searchLink fieldCode="DE" term="%22Ultrasonic+imaging%22">Ultrasonic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Equipment+%26+supplies%22">Equipment & supplies</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2.5-MHz transmit frequency. Radiofrequency data were processed and subharmonic amplitudes were compared with the pressure catheter data. The correlation coefficient between subharmonic signals and pressure catheter data ranged from -0.3 to -0.9. For acquisitions with optimum acoustic output, pressure errors between the subharmonic technique and catheter were as low as 2.6 mmHg. However, automatically determining optimum acoustic output during scanning for each patient remains to be addressed before clinical applicability can be decided. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=125195174
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ultrasmedbio.2017.07.009
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Cardiac catheterization
        Type: general
      – SubjectFull: Ultrasound contrast media
        Type: general
      – SubjectFull: Noninvasive diagnostic tests
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      – SubjectFull: Systolic blood pressure
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      – SubjectFull: Cardiovascular disease diagnosis
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      – SubjectFull: Blood pressure measurement
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      – SubjectFull: Diagnostic imaging
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      – SubjectFull: Fluorocarbons
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      – SubjectFull: Heart ventricles
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      – SubjectFull: Research funding
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      – SubjectFull: Signal processing
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      – SubjectFull: Sound
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      – SubjectFull: Ultrasonic imaging
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      – SubjectFull: Equipment & supplies
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      – SubjectFull: Contrast media
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      – SubjectFull: Physiology
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      – TitleFull: Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.
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