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Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.

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Title: Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans.
Authors: Dave, Jaydev K.1 jaydev.dave@jefferson.edu, Kulkarni, Sushmita V.1,2, Pangaonkar, Purva P.1,3, Stanczak, Maria1, Mcdonald, Maureen E.4, Cohen, Ira S.5, Mehrotra, Praveen5, Savage, Michael P.5, Walinsky, Paul5, Iiruggiero, Nicholas J.5, Fischman, David L.5, Ogilby, David5, Vanwhy, Carolyn5, Lombardi, Matthew5, Forsberg, Flemming1, Ruggiero, Nicholas J 2nd5 (AUTHOR)
Source: Ultrasound in Medicine & Biology. Nov2017, Vol. 43 Issue 11, p2718-2724. 7p.
Subjects: Cardiac catheterization, Ultrasound contrast media, Noninvasive diagnostic tests, Systolic blood pressure, Cardiovascular disease diagnosis, Blood pressure measurement, Diagnostic imaging, Fluorocarbons, Heart ventricles, Research funding, Signal processing, Sound, Ultrasonic imaging, Equipment & supplies, Contrast media, Physiology
Abstract: This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2.5-MHz transmit frequency. Radiofrequency data were processed and subharmonic amplitudes were compared with the pressure catheter data. The correlation coefficient between subharmonic signals and pressure catheter data ranged from -0.3 to -0.9. For acquisitions with optimum acoustic output, pressure errors between the subharmonic technique and catheter were as low as 2.6 mmHg. However, automatically determining optimum acoustic output during scanning for each patient remains to be addressed before clinical applicability can be decided. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2.5-MHz transmit frequency. Radiofrequency data were processed and subharmonic amplitudes were compared with the pressure catheter data. The correlation coefficient between subharmonic signals and pressure catheter data ranged from -0.3 to -0.9. For acquisitions with optimum acoustic output, pressure errors between the subharmonic technique and catheter were as low as 2.6 mmHg. However, automatically determining optimum acoustic output during scanning for each patient remains to be addressed before clinical applicability can be decided. [ABSTRACT FROM AUTHOR]
ISSN:03015629
DOI:10.1016/j.ultrasmedbio.2017.07.009