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Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins.

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Title: Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins.
Authors: Makowski, Marcus, Jansen, Christian1, Ebersberger, Ullrich2, Schaeffter, Tobias, Razavi, Reza, Mangino, Massimo, Spector, Tim2, Botnar, Rene, Greil, Gerald F. gerald.greil@kcl.ac.uk, Makowski, Marcus R3,4,5,6,7 (AUTHOR), Jansen, Christian H P3 (AUTHOR), Spector, Tim D8 (AUTHOR), Botnar, Rene M3,4,5,6 (AUTHOR)
Source: European Radiology. Nov2017, Vol. 27 Issue 11, p4612-4618. 7p. 3 Diagrams, 1 Chart, 2 Graphs.
Subjects: Gadolinium, Obesity, Twins, Coronary disease, Body mass index
Abstract: Objectives: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease.Methods: Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified.Results: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p < 0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI.Conclusions: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population.Key Points: • BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. • Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. • In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. • Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Makowski%2C+Marcus%22&quot;&gt;Makowski, Marcus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jansen%2C+Christian%22&quot;&gt;Jansen, Christian&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ebersberger%2C+Ullrich%22&quot;&gt;Ebersberger, Ullrich&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schaeffter%2C+Tobias%22&quot;&gt;Schaeffter, Tobias&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Razavi%2C+Reza%22&quot;&gt;Razavi, Reza&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mangino%2C+Massimo%22&quot;&gt;Mangino, Massimo&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Spector%2C+Tim%22&quot;&gt;Spector, Tim&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Botnar%2C+Rene%22&quot;&gt;Botnar, Rene&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Greil%2C+Gerald+F%2E%22&quot;&gt;Greil, Gerald F.&lt;/searchLink&gt;&lt;i&gt; gerald.greil@kcl.ac.uk&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Makowski%2C+Marcus+R%22&quot;&gt;Makowski, Marcus R&lt;/searchLink&gt;&lt;relatesTo&gt;3,4,5,6,7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jansen%2C+Christian+H+P%22&quot;&gt;Jansen, Christian H P&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Spector%2C+Tim+D%22&quot;&gt;Spector, Tim D&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Botnar%2C+Rene+M%22&quot;&gt;Botnar, Rene M&lt;/searchLink&gt;&lt;relatesTo&gt;3,4,5,6&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Nov2017, Vol. 27 Issue 11, p4612-4618. 7p. 3 Diagrams, 1 Chart, 2 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gadolinium%22&quot;&gt;Gadolinium&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Obesity%22&quot;&gt;Obesity&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Twins%22&quot;&gt;Twins&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coronary+disease%22&quot;&gt;Coronary disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Body+mass+index%22&quot;&gt;Body mass index&lt;/searchLink&gt;
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  Data: &lt;bold&gt;Objectives: &lt;/bold&gt;The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease.&lt;bold&gt;Methods: &lt;/bold&gt;Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (&gt;1.6&#160;kg/m2) were recruited out of &gt;10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2&#160;mmol/kg of Gd-DTPA on a 1.5&#160;T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified.&lt;bold&gt;Results: &lt;/bold&gt;An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 &#177; 1.5 vs. 3.5 &#177; 1.6, p &lt; 0.0001) and increased coronary wall enhancement (6.1 &#177; 1.1 vs. 4.8 &#177; 0.9, p = 0.0027) compared to matched twins with lower BMI.&lt;bold&gt;Conclusions: &lt;/bold&gt;This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population.&lt;bold&gt;Key Points: &lt;/bold&gt;• BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. • Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. • In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. • Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – SubjectFull: Gadolinium
        Type: general
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      – SubjectFull: Twins
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      – SubjectFull: Body mass index
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