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Differences between time domain and Fourier domain optical coherence tomography in imaging tissues.

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Title: Differences between time domain and Fourier domain optical coherence tomography in imaging tissues.
Authors: GAO, W.1 wgao@njust.edu.cn, WU, X.1
Source: Journal of Microscopy. Nov2017, Vol. 268 Issue 2, p119-128. 10p.
Subjects: Optical coherence tomography, Fourier transforms, Scattering potentials, Interferometry, Optical tomography
Abstract (English): It has been numerously demonstrated that both time domain and Fourier domain optical coherence tomography (OCT) can generate high-resolution depth-resolved images of living tissues and cells. In this work, we compare the common points and differences between two methods when the continuous and random properties of live tissue are taken into account. It is found that when relationships that exist between the scattered light and tissue structures are taken into account, spectral interference measurements in Fourier domain OCT (FDOCT) is more advantageous than interference fringe envelope measurements in time domain OCT (TDOCT) in the cases where continuous property of tissue is taken into account. It is also demonstrated that when random property of tissue is taken into account FDOCT measures the Fourier transform of the spatial correlation function of the refractive index and speckle phenomena will limit the effective limiting imaging resolution in both TDOCT and FDOCT. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical applications. [ABSTRACT FROM AUTHOR]
Abstract (Portuguese): Lay description In this work, the common points and differences are compared between time domain optical coherence tomography (TDOCT) and Fourier domain OCT (FDOCT) in terms of limiting resolution. It is found that the resolution achievable in both TDOCT and FDOCT are influenced by tissue induced dispersion and speckle effects. It is also demonstrated that when the relationships that exist between the scattered light and tissue structures are taken into account, the spectral interference measurements in FDOCT is more advantageous than the interference fringe envelope measurements in TDOCT in the cases where the continuous structures of tissue are imaged. On one hand, the coherence gate selection interpretation in TDOCT is only valid for the cases where the discrete scatterers separated by a distance larger than the coherence length or the interfaces between the layered structures of tissue are of interest. On other hand, in addition to capability of imaging deterministic discrete and continuous structural components of live tissue, FDOCT can detect the Fourier transform of the spatial correlation function of the refractive index. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical cases. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Microscopy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Differences between time domain and Fourier domain optical coherence tomography in imaging tissues.
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  Label: Abstract (English)
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  Data: It has been numerously demonstrated that both time domain and Fourier domain optical coherence tomography (OCT) can generate high-resolution depth-resolved images of living tissues and cells. In this work, we compare the common points and differences between two methods when the continuous and random properties of live tissue are taken into account. It is found that when relationships that exist between the scattered light and tissue structures are taken into account, spectral interference measurements in Fourier domain OCT (FDOCT) is more advantageous than interference fringe envelope measurements in time domain OCT (TDOCT) in the cases where continuous property of tissue is taken into account. It is also demonstrated that when random property of tissue is taken into account FDOCT measures the Fourier transform of the spatial correlation function of the refractive index and speckle phenomena will limit the effective limiting imaging resolution in both TDOCT and FDOCT. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical applications. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Portuguese)
  Group: Ab
  Data: Lay description In this work, the common points and differences are compared between time domain optical coherence tomography (TDOCT) and Fourier domain OCT (FDOCT) in terms of limiting resolution. It is found that the resolution achievable in both TDOCT and FDOCT are influenced by tissue induced dispersion and speckle effects. It is also demonstrated that when the relationships that exist between the scattered light and tissue structures are taken into account, the spectral interference measurements in FDOCT is more advantageous than the interference fringe envelope measurements in TDOCT in the cases where the continuous structures of tissue are imaged. On one hand, the coherence gate selection interpretation in TDOCT is only valid for the cases where the discrete scatterers separated by a distance larger than the coherence length or the interfaces between the layered structures of tissue are of interest. On other hand, in addition to capability of imaging deterministic discrete and continuous structural components of live tissue, FDOCT can detect the Fourier transform of the spatial correlation function of the refractive index. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical cases. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Microscopy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Scattering potentials
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              Text: Nov2017
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