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Investigation on replication of microfluidic channels by hot embossing.

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Title: Investigation on replication of microfluidic channels by hot embossing.
Authors: Çoğun, Ferah1,2 (AUTHOR) ferahco@cankaya.edu.tr, Yıldırım, Ender1 (AUTHOR), Sahir Arikan, M. A.2 (AUTHOR)
Source: Materials & Manufacturing Processes. 2017, Vol. 32 Issue 16, p1838-1844. 7p.
Subjects: Microfluidic devices -- Design & construction, Embossing (Metalwork), Hot working of metals, Analysis of variance, Finite element method, Skewness (Probability theory)
Abstract: In this study, effects of embossing temperature, time, and force on production of a microfluidic device were investigated. Polymethyl methacrylate (PMMA) substrates were hot embossed by using a micromilled aluminum mold. The process parameters were altered to observe the variation of replication rate in width and depth as well as symmetry of the replicated microfluidic channels. Analysis of variance (ANOVA) on the experimental results indicated that embossing temperature was the most important process parameter, whereas embossing time and force have less impact. One distinguishing aspect of this study is that, the channels were observed to be skewed to either side of the channel depending on the location of the protrusions on the mold. The mechanism of the skewness was investigated by finite element analysis and discussed in detail. Results showed that the skewness depends on the flow characteristics of the material and could be reduced by increasing the embossing temperature. The best replication rates were obtained at parameter settings of 115°C, 10 kN, and 8 min for the molds with minimum 56 µm wide features of 120 µm depth. We also showed that the fabricated channels could be successfully sealed by solvent-assisted thermo-compressive bonding at 85°C under 5.5 kN force. [ABSTRACT FROM AUTHOR]
Copyright of Materials & Manufacturing Processes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Investigation on replication of microfluidic channels by hot embossing.
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  Data: <searchLink fieldCode="AR" term="%22Çoğun%2C+Ferah%22">Çoğun, Ferah</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> ferahco@cankaya.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Yıldırım%2C+Ender%22">Yıldırım, Ender</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sahir+Arikan%2C+M%2E+A%2E%22">Sahir Arikan, M. A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Materials+%26+Manufacturing+Processes%22">Materials & Manufacturing Processes</searchLink>. 2017, Vol. 32 Issue 16, p1838-1844. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Microfluidic+devices+--+Design+%26+construction%22">Microfluidic devices -- Design & construction</searchLink><br /><searchLink fieldCode="DE" term="%22Embossing+%28Metalwork%29%22">Embossing (Metalwork)</searchLink><br /><searchLink fieldCode="DE" term="%22Hot+working+of+metals%22">Hot working of metals</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Finite+element+method%22">Finite element method</searchLink><br /><searchLink fieldCode="DE" term="%22Skewness+%28Probability+theory%29%22">Skewness (Probability theory)</searchLink>
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  Data: In this study, effects of embossing temperature, time, and force on production of a microfluidic device were investigated. Polymethyl methacrylate (PMMA) substrates were hot embossed by using a micromilled aluminum mold. The process parameters were altered to observe the variation of replication rate in width and depth as well as symmetry of the replicated microfluidic channels. Analysis of variance (ANOVA) on the experimental results indicated that embossing temperature was the most important process parameter, whereas embossing time and force have less impact. One distinguishing aspect of this study is that, the channels were observed to be skewed to either side of the channel depending on the location of the protrusions on the mold. The mechanism of the skewness was investigated by finite element analysis and discussed in detail. Results showed that the skewness depends on the flow characteristics of the material and could be reduced by increasing the embossing temperature. The best replication rates were obtained at parameter settings of 115°C, 10 kN, and 8 min for the molds with minimum 56 µm wide features of 120 µm depth. We also showed that the fabricated channels could be successfully sealed by solvent-assisted thermo-compressive bonding at 85°C under 5.5 kN force. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Materials & Manufacturing Processes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/10426914.2017.1317795
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        Text: English
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        PageCount: 7
        StartPage: 1838
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      – SubjectFull: Microfluidic devices -- Design & construction
        Type: general
      – SubjectFull: Embossing (Metalwork)
        Type: general
      – SubjectFull: Hot working of metals
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Finite element method
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      – SubjectFull: Skewness (Probability theory)
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      – TitleFull: Investigation on replication of microfluidic channels by hot embossing.
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            NameFull: Çoğun, Ferah
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            NameFull: Yıldırım, Ender
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            NameFull: Sahir Arikan, M. A.
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              Text: 2017
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