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Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool.

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Title: Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool.
Authors: Espín-Pérez, Almudena1 a.espin@maastrichtuniversity.nl, Font-Ribera, Laia2, van Veldhoven, Karin3, Krauskopf, Julian1, Portengen, Lutzen4, Chadeau-Hyam, Marc3, Vermeulen, Roel4, Grimalt, Joan O.5, Villanueva, Cristina M.2, Vineis, Paolo3, Kogevinas, Manolis2, Kleinjans, Jos C.1, de Kok, Theo M.1
Source: Environment International. Jan2018, Vol. 110, p42-50. 9p.
Subjects: Bladder cancer risk factors, Disinfectants & the environment, MicroRNA, Gene expression, Blood sampling
Abstract: Background Swimming in a chlorinated pool results in high exposure levels to disinfection by-products (DBPs), which have been associated with an increased risk of bladder cancer. Objectives By studying molecular responses at the blood transcriptome level we examined the biological processes associated with exposure to these compounds. Methods Whole-genome gene expression and microRNA analysis was performed on blood samples collected from 43 volunteers before and 2 h after 40 min swimming in an indoor chlorinated pool (PISCINAII study). Exposure to THMs was measured in exhaled breath. Heart rate and kcal expenditure were measured as proxies for physical activity. Associations between exposure levels and gene expression were assessed using multivariate normal models (MVN), correcting for age, body mass index and sex. A Bonferroni threshold at 5% was applied. Results MVN-models for the individual exposures identified 1778 genes and 23 microRNAs that were significantly associated with exposure to at least one DBP. Due to co-linearity it was not possible to statistically disentangle responses to DBP exposure from those related to physical activity. However, after eliminating previously reported transcripts associated with physical activity a large number of hits remained associated with DBP exposure. Among those, 9 were linked with bladder and 31 with colon cancer. Concordant microRNA/mRNA expressions were identified in association with DBP exposure for hsa-mir-22-3p and hsa-miR-146a-5p and their targets RCOR1 and TLR4, both related to colon cancer in association with DBP exposure. Conclusions Short-term exposure to low levels of DBPs shows genomics responses that may be indicative of increased cancer risk. [ABSTRACT FROM AUTHOR]
Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubTypeId: academicJournal
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  Data: Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool.
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  Data: <searchLink fieldCode="AR" term="%22Espín-Pérez%2C+Almudena%22">Espín-Pérez, Almudena</searchLink><relatesTo>1</relatesTo><i> a.espin@maastrichtuniversity.nl</i><br /><searchLink fieldCode="AR" term="%22Font-Ribera%2C+Laia%22">Font-Ribera, Laia</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22van+Veldhoven%2C+Karin%22">van Veldhoven, Karin</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Krauskopf%2C+Julian%22">Krauskopf, Julian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Portengen%2C+Lutzen%22">Portengen, Lutzen</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Chadeau-Hyam%2C+Marc%22">Chadeau-Hyam, Marc</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Vermeulen%2C+Roel%22">Vermeulen, Roel</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Grimalt%2C+Joan+O%2E%22">Grimalt, Joan O.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Villanueva%2C+Cristina+M%2E%22">Villanueva, Cristina M.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Vineis%2C+Paolo%22">Vineis, Paolo</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Kogevinas%2C+Manolis%22">Kogevinas, Manolis</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kleinjans%2C+Jos+C%2E%22">Kleinjans, Jos C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Kok%2C+Theo+M%2E%22">de Kok, Theo M.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Environment+International%22">Environment International</searchLink>. Jan2018, Vol. 110, p42-50. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Bladder+cancer+risk+factors%22">Bladder cancer risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Disinfectants+%26+the+environment%22">Disinfectants & the environment</searchLink><br /><searchLink fieldCode="DE" term="%22MicroRNA%22">MicroRNA</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sampling%22">Blood sampling</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background Swimming in a chlorinated pool results in high exposure levels to disinfection by-products (DBPs), which have been associated with an increased risk of bladder cancer. Objectives By studying molecular responses at the blood transcriptome level we examined the biological processes associated with exposure to these compounds. Methods Whole-genome gene expression and microRNA analysis was performed on blood samples collected from 43 volunteers before and 2 h after 40 min swimming in an indoor chlorinated pool (PISCINAII study). Exposure to THMs was measured in exhaled breath. Heart rate and kcal expenditure were measured as proxies for physical activity. Associations between exposure levels and gene expression were assessed using multivariate normal models (MVN), correcting for age, body mass index and sex. A Bonferroni threshold at 5% was applied. Results MVN-models for the individual exposures identified 1778 genes and 23 microRNAs that were significantly associated with exposure to at least one DBP. Due to co-linearity it was not possible to statistically disentangle responses to DBP exposure from those related to physical activity. However, after eliminating previously reported transcripts associated with physical activity a large number of hits remained associated with DBP exposure. Among those, 9 were linked with bladder and 31 with colon cancer. Concordant microRNA/mRNA expressions were identified in association with DBP exposure for hsa-mir-22-3p and hsa-miR-146a-5p and their targets RCOR1 and TLR4, both related to colon cancer in association with DBP exposure. Conclusions Short-term exposure to low levels of DBPs shows genomics responses that may be indicative of increased cancer risk. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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