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Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery.

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Title: Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery.
Authors: Angulo, O.1, Gandrillon, O.2,3, Crauste, F.3,4 fabien.crauste@inria.fr
Source: Journal of Theoretical Biology. Jan2018, Vol. 437, p286-298. 13p.
Subjects: Erythrocytes, Blood cells, Cell growth, Erythrocyte membranes, Progenitor cells
Abstract: Production of red blood cells involves growth-factor mediated regulation of erythroid progenitor apoptosis and self-renewal. During severe anemia, characterized by a strong fall of the hematocrit followed by a recovery phase, these controls allow a fast recovery of the hematocrit and survival of the organism. Using a mathematical model of stress erythropoiesis and an ad hoc numerical method, we investigate the respective roles of anemia-inducing phenylhydrazine injections and physiological regulation on the organism’s recovery. By explicitly modeling the experimental protocol, we show that it mostly characterizes the fall of the hematocrit following the anemia and its severeness, while physiological process regulation mainly controls the recovery. We confront our model and our conclusions to similar experiments inducing anemia and show the model’s ability to reproduce several protocols of phenylhydrazine-induced anemia. In particular, we establish a link between phenylhydrazine effect and the severeness of the anemia. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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  Data: Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery.
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  Data: <searchLink fieldCode="AR" term="%22Angulo%2C+O%2E%22">Angulo, O.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gandrillon%2C+O%2E%22">Gandrillon, O.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Crauste%2C+F%2E%22">Crauste, F.</searchLink><relatesTo>3,4</relatesTo><i> fabien.crauste@inria.fr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Theoretical+Biology%22">Journal of Theoretical Biology</searchLink>. Jan2018, Vol. 437, p286-298. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Erythrocytes%22">Erythrocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+cells%22">Blood cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+growth%22">Cell growth</searchLink><br /><searchLink fieldCode="DE" term="%22Erythrocyte+membranes%22">Erythrocyte membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Progenitor+cells%22">Progenitor cells</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Production of red blood cells involves growth-factor mediated regulation of erythroid progenitor apoptosis and self-renewal. During severe anemia, characterized by a strong fall of the hematocrit followed by a recovery phase, these controls allow a fast recovery of the hematocrit and survival of the organism. Using a mathematical model of stress erythropoiesis and an ad hoc numerical method, we investigate the respective roles of anemia-inducing phenylhydrazine injections and physiological regulation on the organism’s recovery. By explicitly modeling the experimental protocol, we show that it mostly characterizes the fall of the hematocrit following the anemia and its severeness, while physiological process regulation mainly controls the recovery. We confront our model and our conclusions to similar experiments inducing anemia and show the model’s ability to reproduce several protocols of phenylhydrazine-induced anemia. In particular, we establish a link between phenylhydrazine effect and the severeness of the anemia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.jtbi.2017.10.031
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 286
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      – SubjectFull: Erythrocytes
        Type: general
      – SubjectFull: Blood cells
        Type: general
      – SubjectFull: Cell growth
        Type: general
      – SubjectFull: Erythrocyte membranes
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      – SubjectFull: Progenitor cells
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      – TitleFull: Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery.
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              Text: Jan2018
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