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An improved procedure for integrated behavioral z-scoring illustrated with modified Hole Board behavior of male inbred laboratory mice.

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Title: An improved procedure for integrated behavioral z-scoring illustrated with modified Hole Board behavior of male inbred laboratory mice.
Authors: Labots, M. (Maaike)1,2 M.Labots@uu.nl, Laarakker, M.C. (Marijke)1,2 Marijke.Laarakker@gmail.com, Schetters, D. (Dustin)1 D.Schetters@vumc.nl, Arndt, S.S. (Saskia)1,2 S.S.Arndt@uu.nl, van Lith, H.A. (Hein)1,2 H.A.vanLith@uu.nl
Source: Journal of Neuroscience Methods. Jan2018, Vol. 293, p375-388. 14p.
Subjects: Phenotypes, Laboratory mice, Anxiety, Radioimmunoassay, Mice behavior
Abstract: Background Guilloux et al. introduced: integrated behavioral z-scoring, a method for behavioral phenotyping of mice. Using this method multiple ethological variables can be combined to show an overall description of a certain behavioral dimension or motivational system. However, a problem may occur when the control group used for the calculation has a standard deviation of zero or when no control group is present to act as a reference group. New method In order to solve these problems, an improved procedure is suggested: taking the pooled data as reference. For this purpose a behavioral study with male mice from three inbred strains was carried out. The integrated behavioral z-scoring methodology was applied, thereby taking five different reference group options. The outcome regarding statistical significance and practical importance was compared. Results Significant effects and effect sizes were influenced by the choice of the reference group. In some cases it was impossible to use a certain population and condition, because one or more behavioral variables in question had a standard deviation of zero. Based on the improved method, male mice from the three inbred strains differed regarding activity and anxiety. Comparison with existing method Taking the method described by Guilloux et al. as basis, the present procedure improved the generalizability to all types of experimental designs in animal behavioral research. Conclusions To solve the aforementioned problems and to avoid getting the diagnosis of data manipulation, the pooled data (combining the data from all experimental groups in a study) as reference option is recommended. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Neuroscience Methods is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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  Data: An improved procedure for integrated behavioral z-scoring illustrated with modified Hole Board behavior of male inbred laboratory mice.
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  Data: <searchLink fieldCode="AR" term="%22Labots%2C+M%2E+%28Maaike%29%22">Labots, M. (Maaike)</searchLink><relatesTo>1,2</relatesTo><i> M.Labots@uu.nl</i><br /><searchLink fieldCode="AR" term="%22Laarakker%2C+M%2EC%2E+%28Marijke%29%22">Laarakker, M.C. (Marijke)</searchLink><relatesTo>1,2</relatesTo><i> Marijke.Laarakker@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Schetters%2C+D%2E+%28Dustin%29%22">Schetters, D. (Dustin)</searchLink><relatesTo>1</relatesTo><i> D.Schetters@vumc.nl</i><br /><searchLink fieldCode="AR" term="%22Arndt%2C+S%2ES%2E+%28Saskia%29%22">Arndt, S.S. (Saskia)</searchLink><relatesTo>1,2</relatesTo><i> S.S.Arndt@uu.nl</i><br /><searchLink fieldCode="AR" term="%22van+Lith%2C+H%2EA%2E+%28Hein%29%22">van Lith, H.A. (Hein)</searchLink><relatesTo>1,2</relatesTo><i> H.A.vanLith@uu.nl</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Neuroscience+Methods%22">Journal of Neuroscience Methods</searchLink>. Jan2018, Vol. 293, p375-388. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Radioimmunoassay%22">Radioimmunoassay</searchLink><br /><searchLink fieldCode="DE" term="%22Mice+behavior%22">Mice behavior</searchLink>
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  Data: Background Guilloux et al. introduced: integrated behavioral z-scoring, a method for behavioral phenotyping of mice. Using this method multiple ethological variables can be combined to show an overall description of a certain behavioral dimension or motivational system. However, a problem may occur when the control group used for the calculation has a standard deviation of zero or when no control group is present to act as a reference group. New method In order to solve these problems, an improved procedure is suggested: taking the pooled data as reference. For this purpose a behavioral study with male mice from three inbred strains was carried out. The integrated behavioral z-scoring methodology was applied, thereby taking five different reference group options. The outcome regarding statistical significance and practical importance was compared. Results Significant effects and effect sizes were influenced by the choice of the reference group. In some cases it was impossible to use a certain population and condition, because one or more behavioral variables in question had a standard deviation of zero. Based on the improved method, male mice from the three inbred strains differed regarding activity and anxiety. Comparison with existing method Taking the method described by Guilloux et al. as basis, the present procedure improved the generalizability to all types of experimental designs in animal behavioral research. Conclusions To solve the aforementioned problems and to avoid getting the diagnosis of data manipulation, the pooled data (combining the data from all experimental groups in a study) as reference option is recommended. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Neuroscience Methods is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.jneumeth.2017.09.003
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        Text: English
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      – SubjectFull: Radioimmunoassay
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      – SubjectFull: Mice behavior
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      – TitleFull: An improved procedure for integrated behavioral z-scoring illustrated with modified Hole Board behavior of male inbred laboratory mice.
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              Text: Jan2018
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