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Surface modification of platelet concentrate bags to reduce biofilm formation and transfusion sepsis.

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Title: Surface modification of platelet concentrate bags to reduce biofilm formation and transfusion sepsis.
Authors: Wilson-Nieuwenhuis, Joels S.t.1, Dempsey-Hibbert, Nina1, Liauw, Christopher M.1, Whitehead, Kathryn A.1 K.A.Whitehead@mmu.ac.uk
Source: Colloids & Surfaces B: Biointerfaces. Dec2017, Vol. 160, p126-135. 10p.
Subjects: Blood platelet transfusion, Biofilms testing, Sepsis, Bacterial contamination, Bacteria hydrophilicity & hydrophobicity, Diagnosis, Prevention
Abstract: Bacterial contamination of blood products poses a major risk in transfusion medicine, including transfusions involving platelet products. Although testing systems are in place for routine screening of platelet units, the formation of bacterial biofilms in such units may decrease the likelihood that bacteria will be detected. This work determined the surface properties of p-PVC platelet concentrate bags and investigated how these characteristics influenced biofilm formation. Serratia marcescens and Staphylococcus epidermidis , two species commonly implicated in platelet contamination, were used to study biofilm growth. The platelet concentrate bags were physically flattened to determine if reducing the surface roughness altered biofilm formation. The results demonstrated that the flattening process of the platelet bags affected the chemistry of the surface and reduced the surface hydrophobicity. Flattening of the surfaces resulted in a reduction in biofilm formation for both species after 5 days, with S. marcescens demonstrating a greater reduction. However, there was no significant difference between the smooth and flat surfaces following 7 days’ incubation for S. marcescens and no significant differences between any of the surfaces following 7 days’ incubation for S. epidermidis . The results suggest that flattening the p-PVC surfaces may limit potential biofilm formation for the current duration of platelet storage time of 5 days. It is hoped that this work will enhance the understanding of how surface properties influence the development of microbial biofilms in platelet concentrate bags in order to devise a solution to discourage biofilm formation. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 126573814
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Surface modification of platelet concentrate bags to reduce biofilm formation and transfusion sepsis.
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  Data: <searchLink fieldCode="AR" term="%22Wilson-Nieuwenhuis%2C+Joels+S%2Et%2E%22">Wilson-Nieuwenhuis, Joels S.t.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dempsey-Hibbert%2C+Nina%22">Dempsey-Hibbert, Nina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liauw%2C+Christopher+M%2E%22">Liauw, Christopher M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Whitehead%2C+Kathryn+A%2E%22">Whitehead, Kathryn A.</searchLink><relatesTo>1</relatesTo><i> K.A.Whitehead@mmu.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Dec2017, Vol. 160, p126-135. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Blood+platelet+transfusion%22">Blood platelet transfusion</searchLink><br /><searchLink fieldCode="DE" term="%22Biofilms+testing%22">Biofilms testing</searchLink><br /><searchLink fieldCode="DE" term="%22Sepsis%22">Sepsis</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+contamination%22">Bacterial contamination</searchLink><br /><searchLink fieldCode="DE" term="%22Bacteria+hydrophilicity+%26+hydrophobicity%22">Bacteria hydrophilicity & hydrophobicity</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Bacterial contamination of blood products poses a major risk in transfusion medicine, including transfusions involving platelet products. Although testing systems are in place for routine screening of platelet units, the formation of bacterial biofilms in such units may decrease the likelihood that bacteria will be detected. This work determined the surface properties of p-PVC platelet concentrate bags and investigated how these characteristics influenced biofilm formation. Serratia marcescens and Staphylococcus epidermidis , two species commonly implicated in platelet contamination, were used to study biofilm growth. The platelet concentrate bags were physically flattened to determine if reducing the surface roughness altered biofilm formation. The results demonstrated that the flattening process of the platelet bags affected the chemistry of the surface and reduced the surface hydrophobicity. Flattening of the surfaces resulted in a reduction in biofilm formation for both species after 5 days, with S. marcescens demonstrating a greater reduction. However, there was no significant difference between the smooth and flat surfaces following 7 days’ incubation for S. marcescens and no significant differences between any of the surfaces following 7 days’ incubation for S. epidermidis . The results suggest that flattening the p-PVC surfaces may limit potential biofilm formation for the current duration of platelet storage time of 5 days. It is hoped that this work will enhance the understanding of how surface properties influence the development of microbial biofilms in platelet concentrate bags in order to devise a solution to discourage biofilm formation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.colsurfb.2017.09.019
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 126
    Subjects:
      – SubjectFull: Blood platelet transfusion
        Type: general
      – SubjectFull: Biofilms testing
        Type: general
      – SubjectFull: Sepsis
        Type: general
      – SubjectFull: Bacterial contamination
        Type: general
      – SubjectFull: Bacteria hydrophilicity & hydrophobicity
        Type: general
      – SubjectFull: Diagnosis
        Type: general
      – SubjectFull: Prevention
        Type: general
    Titles:
      – TitleFull: Surface modification of platelet concentrate bags to reduce biofilm formation and transfusion sepsis.
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            NameFull: Wilson-Nieuwenhuis, Joels S.t.
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            NameFull: Dempsey-Hibbert, Nina
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            NameFull: Liauw, Christopher M.
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            NameFull: Whitehead, Kathryn A.
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              M: 12
              Text: Dec2017
              Type: published
              Y: 2017
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