Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization.
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| Title: | Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization. |
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| Authors: | Junxin Wang1,2, Ching-Yu Lin1,2, Moore, Colman1,2, Jhunjhunwala, Anamik2, Jokerst, Jesse V.1,2 jjokerst@ucsd.edu |
| Source: | Langmuir. 1/9/2018, Vol. 34 Issue 1, p359-365. 7p. |
| Subjects: | Methylene blue, Acoustic imaging, Sodium dodecyl sulfate, Nanoparticles, Critical micelle concentration, Addition reactions |
| Abstract: | The interaction between methylene blue (MB) and sodium dodecyl sulfate (SDS) has been widely studied spectroscopically, but details about their interactions remain unclear. Here, we combined photoacoustic (PA) imaging with nanoparticle tracking analysis (NTA) and spectroscopy to further elucidate this interaction. PA imaging of 0.05 mM MB showed a 492-fold increase in intensity upon the addition of 3.47 mM SDS. Higher concentrations above SDS's critical micelle concentration (CMC) at 8.67 mM decreased the PA intensity by 54 times. Relative quantum yield measurements indicated that PA intensity increased as a result of fluorescence quenching. Meanwhile, NTA indicated an increased number of nonmicellar MB/SDS clusters at SDS concentrations below the CMC varying in size from 80 to 400 nm as well as a decreased number above the CMC. This trend suggested that MB/SDS clusters are responsible for the PA intensity enhancement. Comparison of PA intensities and spectral shifts with MB/hexadecyltrimethylammonium bromide, MB/sodium octyl sulfate, and MB/sodium chloride demonstrated that MB was bound to the sulfate moiety of SDS before and after micellization. Our observations suggest that MB forms aggregates with SDS at premicellar concentrations, and the MB aggregates disassociate as monomers that are bound to the sulfate moiety of SDS at micellar concentrations. These findings further clarify the process by which MB and SDS interact and demonstrate the potential for developing MB-/SDS-based contrast agents. [ABSTRACT FROM AUTHOR] |
| Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 127244917 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Junxin+Wang%22">Junxin Wang</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ching-Yu+Lin%22">Ching-Yu Lin</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Moore%2C+Colman%22">Moore, Colman</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jhunjhunwala%2C+Anamik%22">Jhunjhunwala, Anamik</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jokerst%2C+Jesse+V%2E%22">Jokerst, Jesse V.</searchLink><relatesTo>1,2</relatesTo><i> jjokerst@ucsd.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Langmuir%22">Langmuir</searchLink>. 1/9/2018, Vol. 34 Issue 1, p359-365. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Methylene+blue%22">Methylene blue</searchLink><br /><searchLink fieldCode="DE" term="%22Acoustic+imaging%22">Acoustic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium+dodecyl+sulfate%22">Sodium dodecyl sulfate</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Critical+micelle+concentration%22">Critical micelle concentration</searchLink><br /><searchLink fieldCode="DE" term="%22Addition+reactions%22">Addition reactions</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The interaction between methylene blue (MB) and sodium dodecyl sulfate (SDS) has been widely studied spectroscopically, but details about their interactions remain unclear. Here, we combined photoacoustic (PA) imaging with nanoparticle tracking analysis (NTA) and spectroscopy to further elucidate this interaction. PA imaging of 0.05 mM MB showed a 492-fold increase in intensity upon the addition of 3.47 mM SDS. Higher concentrations above SDS's critical micelle concentration (CMC) at 8.67 mM decreased the PA intensity by 54 times. Relative quantum yield measurements indicated that PA intensity increased as a result of fluorescence quenching. Meanwhile, NTA indicated an increased number of nonmicellar MB/SDS clusters at SDS concentrations below the CMC varying in size from 80 to 400 nm as well as a decreased number above the CMC. This trend suggested that MB/SDS clusters are responsible for the PA intensity enhancement. Comparison of PA intensities and spectral shifts with MB/hexadecyltrimethylammonium bromide, MB/sodium octyl sulfate, and MB/sodium chloride demonstrated that MB was bound to the sulfate moiety of SDS before and after micellization. Our observations suggest that MB forms aggregates with SDS at premicellar concentrations, and the MB aggregates disassociate as monomers that are bound to the sulfate moiety of SDS at micellar concentrations. These findings further clarify the process by which MB and SDS interact and demonstrate the potential for developing MB-/SDS-based contrast agents. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.langmuir.7b03718 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 359 Subjects: – SubjectFull: Methylene blue Type: general – SubjectFull: Acoustic imaging Type: general – SubjectFull: Sodium dodecyl sulfate Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Critical micelle concentration Type: general – SubjectFull: Addition reactions Type: general Titles: – TitleFull: Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Junxin Wang – PersonEntity: Name: NameFull: Ching-Yu Lin – PersonEntity: Name: NameFull: Moore, Colman – PersonEntity: Name: NameFull: Jhunjhunwala, Anamik – PersonEntity: Name: NameFull: Jokerst, Jesse V. IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 01 Text: 1/9/2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 07437463 Numbering: – Type: volume Value: 34 – Type: issue Value: 1 Titles: – TitleFull: Langmuir Type: main |
| ResultId | 1 |
