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An integrated all foil based micro device for point of care diagnostic applications.

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Title: An integrated all foil based micro device for point of care diagnostic applications.
Authors: Bose, I.1,2, Ohlander, A.1,3, Kutter, C.1,2, Russom, A.3 aman.russom@scilifelab.se
Source: Sensors & Actuators B: Chemical. Apr2018, Vol. 259, p917-925. 9p.
Subjects: Microfluidics, Light emitting diodes, Photonic crystals, Quantum dots, Laser plasmas, Equipment & supplies
Abstract: Point-of-Care (POC) diagnostics often fail to meet the market requirements of low cost and advanced functionality, and are often limited to lateral flow based serological diagnostics with reduced sensitivity and specificity. We report here on an integrated microfluidic absorbance measurement device fabricated by roll-to-roll (R2R) compatible manufacturing processes, suitable for low cost POC systems. It is a device exclusively made of foils and takes external light from a low cost LED and converts the point light source to a homogeneous light via a foil based optical filter at the bottom of the device. The light is converted to an electrical signal by an amorphous organic semiconductor (OSC) material, integrated with screen-printed carbon finger on top of the device for electrical measurement. As a proof of principle, we demonstrate DNA hybridization assay, where the target DNA is coupled to magnetic beads for absorbance measurement. The device successfully distinguishes between matched and mismatched DNA hybridization and can differentiate between 1 μM, 50 nM and 2.5 nM DNA target concentrations. The inherent characteristics of the substrates and R2R fabrication concept significantly reduce the cost, making it suitable for POC applications at resource-limited settings. [ABSTRACT FROM AUTHOR]
Copyright of Sensors & Actuators B: Chemical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 127618733
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: An integrated all foil based micro device for point of care diagnostic applications.
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  Data: <searchLink fieldCode="AR" term="%22Bose%2C+I%2E%22">Bose, I.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ohlander%2C+A%2E%22">Ohlander, A.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Kutter%2C+C%2E%22">Kutter, C.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Russom%2C+A%2E%22">Russom, A.</searchLink><relatesTo>3</relatesTo><i> aman.russom@scilifelab.se</i>
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  Data: <searchLink fieldCode="JN" term="%22Sensors+%26+Actuators+B%3A+Chemical%22">Sensors & Actuators B: Chemical</searchLink>. Apr2018, Vol. 259, p917-925. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Microfluidics%22">Microfluidics</searchLink><br /><searchLink fieldCode="DE" term="%22Light+emitting+diodes%22">Light emitting diodes</searchLink><br /><searchLink fieldCode="DE" term="%22Photonic+crystals%22">Photonic crystals</searchLink><br /><searchLink fieldCode="DE" term="%22Quantum+dots%22">Quantum dots</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+plasmas%22">Laser plasmas</searchLink><br /><searchLink fieldCode="DE" term="%22Equipment+%26+supplies%22">Equipment & supplies</searchLink>
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  Label: Abstract
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  Data: Point-of-Care (POC) diagnostics often fail to meet the market requirements of low cost and advanced functionality, and are often limited to lateral flow based serological diagnostics with reduced sensitivity and specificity. We report here on an integrated microfluidic absorbance measurement device fabricated by roll-to-roll (R2R) compatible manufacturing processes, suitable for low cost POC systems. It is a device exclusively made of foils and takes external light from a low cost LED and converts the point light source to a homogeneous light via a foil based optical filter at the bottom of the device. The light is converted to an electrical signal by an amorphous organic semiconductor (OSC) material, integrated with screen-printed carbon finger on top of the device for electrical measurement. As a proof of principle, we demonstrate DNA hybridization assay, where the target DNA is coupled to magnetic beads for absorbance measurement. The device successfully distinguishes between matched and mismatched DNA hybridization and can differentiate between 1 μM, 50 nM and 2.5 nM DNA target concentrations. The inherent characteristics of the substrates and R2R fabrication concept significantly reduce the cost, making it suitable for POC applications at resource-limited settings. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Sensors & Actuators B: Chemical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.snb.2017.12.133
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Light emitting diodes
        Type: general
      – SubjectFull: Photonic crystals
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      – SubjectFull: Quantum dots
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      – SubjectFull: Laser plasmas
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      – SubjectFull: Equipment & supplies
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      – TitleFull: An integrated all foil based micro device for point of care diagnostic applications.
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              Text: Apr2018
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              Y: 2018
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