Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis.
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| Title: | Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis. |
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| Authors: | Harvianto, Gregorius Rionugroho1, Haider, Junaid1, Hong, Jimin1, Van Duc Long, Nguyen1, Shim, Jae-Jin1, Cho, Moo Hwan1, Kim, Woo Kyoung1, Lee, Moonyong1 3241+82-53-810-2512mynlee@yu.ac.kr |
| Source: | Biotechnology for Biofuels. 1/25/2018, Vol. 11, p1-N.PAG. 16p. |
| Subjects: | Butanediol, Biomass energy, Renewable natural resources, Biomass conversion, Biodiesel fuels |
| Abstract: | Background: 2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation strategies to enhance the production of 2,3- BDO were developed. However, the recovery of 2,3-BDO from its fermentation broth remains a challenge due to its low concentration and its solubility in water and other components. Thus, a cost-effective recovery process is required to deliver the required purity of 2,3-BDO. This paper presents a new process development and techno-economic analysis for 2,3-BDO purification from a fermentation broth. Results: Conventional distillation and hybrid extraction-distillation (HED) processes are proposed in this study with detailed optimization and economic analysis. Particularly, a systematic solvent selection method was successfully implemented to determine a good solvent for the proposed HED configuration based on numerous experimental data obtained with each solvent candidate. NRTL and UNIQUAC property methods were evaluated to obtain binary interaction parameters of 2,3-BDO through rigorous Aspen Plus regression and validated using experimental data. Total annual cost (TAC)-based optimization was performed for each proposed configuration. Even though the HED configuration required 9.5% higher capital cost than conventional distillation, placing an extraction column before the distillation column was effective in removing water from the fermentation broth and significantly improved the overall process economics. Conclusions: Oleyl alcohol was found to be the most suitable solvent for the HED of 2,3-BDO due to its high distribution coefficient and high selectivity. The proposed HED drastically reduced reboiler duty consumption and TAC by up to 54.8 and 25.8%, respectively. The proposed design is expected to be used for the commercial scale of 2,3-BDO production from fermentation process. [ABSTRACT FROM AUTHOR] |
| Copyright of Biotechnology for Biofuels is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 127652970 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Harvianto%2C+Gregorius+Rionugroho%22">Harvianto, Gregorius Rionugroho</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Haider%2C+Junaid%22">Haider, Junaid</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hong%2C+Jimin%22">Hong, Jimin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Van+Duc+Long%2C+Nguyen%22">Van Duc Long, Nguyen</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shim%2C+Jae-Jin%22">Shim, Jae-Jin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cho%2C+Moo+Hwan%22">Cho, Moo Hwan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Woo+Kyoung%22">Kim, Woo Kyoung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Moonyong%22">Lee, Moonyong</searchLink><relatesTo>1</relatesTo><i> 3241+82-53-810-2512mynlee@yu.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biotechnology+for+Biofuels%22">Biotechnology for Biofuels</searchLink>. 1/25/2018, Vol. 11, p1-N.PAG. 16p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Butanediol%22">Butanediol</searchLink><br /><searchLink fieldCode="DE" term="%22Biomass+energy%22">Biomass energy</searchLink><br /><searchLink fieldCode="DE" term="%22Renewable+natural+resources%22">Renewable natural resources</searchLink><br /><searchLink fieldCode="DE" term="%22Biomass+conversion%22">Biomass conversion</searchLink><br /><searchLink fieldCode="DE" term="%22Biodiesel+fuels%22">Biodiesel fuels</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: 2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation strategies to enhance the production of 2,3- BDO were developed. However, the recovery of 2,3-BDO from its fermentation broth remains a challenge due to its low concentration and its solubility in water and other components. Thus, a cost-effective recovery process is required to deliver the required purity of 2,3-BDO. This paper presents a new process development and techno-economic analysis for 2,3-BDO purification from a fermentation broth. Results: Conventional distillation and hybrid extraction-distillation (HED) processes are proposed in this study with detailed optimization and economic analysis. Particularly, a systematic solvent selection method was successfully implemented to determine a good solvent for the proposed HED configuration based on numerous experimental data obtained with each solvent candidate. NRTL and UNIQUAC property methods were evaluated to obtain binary interaction parameters of 2,3-BDO through rigorous Aspen Plus regression and validated using experimental data. Total annual cost (TAC)-based optimization was performed for each proposed configuration. Even though the HED configuration required 9.5% higher capital cost than conventional distillation, placing an extraction column before the distillation column was effective in removing water from the fermentation broth and significantly improved the overall process economics. Conclusions: Oleyl alcohol was found to be the most suitable solvent for the HED of 2,3-BDO due to its high distribution coefficient and high selectivity. The proposed HED drastically reduced reboiler duty consumption and TAC by up to 54.8 and 25.8%, respectively. The proposed design is expected to be used for the commercial scale of 2,3-BDO production from fermentation process. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biotechnology for Biofuels is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13068-018-1013-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 1 Subjects: – SubjectFull: Butanediol Type: general – SubjectFull: Biomass energy Type: general – SubjectFull: Renewable natural resources Type: general – SubjectFull: Biomass conversion Type: general – SubjectFull: Biodiesel fuels Type: general Titles: – TitleFull: Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Harvianto, Gregorius Rionugroho – PersonEntity: Name: NameFull: Haider, Junaid – PersonEntity: Name: NameFull: Hong, Jimin – PersonEntity: Name: NameFull: Van Duc Long, Nguyen – PersonEntity: Name: NameFull: Shim, Jae-Jin – PersonEntity: Name: NameFull: Cho, Moo Hwan – PersonEntity: Name: NameFull: Kim, Woo Kyoung – PersonEntity: Name: NameFull: Lee, Moonyong IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 01 Text: 1/25/2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 17546834 Numbering: – Type: volume Value: 11 Titles: – TitleFull: Biotechnology for Biofuels Type: main |
| ResultId | 1 |
