pH-responsive casein-based films and their application as functional coatings in solid dosage formulations.
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| Title: | pH-responsive casein-based films and their application as functional coatings in solid dosage formulations. |
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| Authors: | Picchio, Matías L.1,2, Paredes, Alejandro J.3, Palma, Santiago D.3, Jr.Passeggi, Mario C.G.4,5, Gugliotta, Luis M.5,6, Minari, Roque J.5,6 rjminari@santafe-conicet.gov.ar, Igarzabal, Cecilia I. Alvarez1 cia@fcq.unc.edu.ar |
| Source: | Colloids & Surfaces A: Physicochemical & Engineering Aspects. Mar2018, Vol. 541, p1-9. 9p. |
| Subjects: | Drug delivery systems, Hydrogen-ion concentration, Caseins, Surface coatings, Solid dosage forms, Atomic force microscopy |
| Abstract: | Over the past few years, there has been increasing attention to the design of new drug delivery systems based on milk proteins due to their excellent functional properties. In this study, we report a new approach for preparing protein-based coating films using highly methacrylated casein as a macro-crosslinker. The films exhibited a smooth surface and an even casein distribution as evidenced by both scanning electron and atomic force microscopy, respectively. The mechanical behavior of the casein-based films could be easily tuned by controlling the degree of methacrylation of the bio-based crosslinker. The as-prepared films showed pH-dependent swelling, in which the swelling ability in alkaline medium was stronger than that at acid pH. The mechanical, swelling, rheological and release performance of the casein-based films suggest that these materials have a high potential as enteric coatings for intestinal drug delivery. [ABSTRACT FROM AUTHOR] |
| Copyright of Colloids & Surfaces A: Physicochemical & Engineering Aspects is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 127961847 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: pH-responsive casein-based films and their application as functional coatings in solid dosage formulations. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Picchio%2C+Matías+L%2E%22">Picchio, Matías L.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Paredes%2C+Alejandro+J%2E%22">Paredes, Alejandro J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Palma%2C+Santiago+D%2E%22">Palma, Santiago D.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Jr%2EPasseggi%2C+Mario+C%2EG%2E%22">Jr.Passeggi, Mario C.G.</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Gugliotta%2C+Luis+M%2E%22">Gugliotta, Luis M.</searchLink><relatesTo>5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Minari%2C+Roque+J%2E%22">Minari, Roque J.</searchLink><relatesTo>5,6</relatesTo><i> rjminari@santafe-conicet.gov.ar</i><br /><searchLink fieldCode="AR" term="%22Igarzabal%2C+Cecilia+I%2E+Alvarez%22">Igarzabal, Cecilia I. Alvarez</searchLink><relatesTo>1</relatesTo><i> cia@fcq.unc.edu.ar</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+A%3A+Physicochemical+%26+Engineering+Aspects%22">Colloids & Surfaces A: Physicochemical & Engineering Aspects</searchLink>. Mar2018, Vol. 541, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen-ion+concentration%22">Hydrogen-ion concentration</searchLink><br /><searchLink fieldCode="DE" term="%22Caseins%22">Caseins</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+coatings%22">Surface coatings</searchLink><br /><searchLink fieldCode="DE" term="%22Solid+dosage+forms%22">Solid dosage forms</searchLink><br /><searchLink fieldCode="DE" term="%22Atomic+force+microscopy%22">Atomic force microscopy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Over the past few years, there has been increasing attention to the design of new drug delivery systems based on milk proteins due to their excellent functional properties. In this study, we report a new approach for preparing protein-based coating films using highly methacrylated casein as a macro-crosslinker. The films exhibited a smooth surface and an even casein distribution as evidenced by both scanning electron and atomic force microscopy, respectively. The mechanical behavior of the casein-based films could be easily tuned by controlling the degree of methacrylation of the bio-based crosslinker. The as-prepared films showed pH-dependent swelling, in which the swelling ability in alkaline medium was stronger than that at acid pH. The mechanical, swelling, rheological and release performance of the casein-based films suggest that these materials have a high potential as enteric coatings for intestinal drug delivery. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Colloids & Surfaces A: Physicochemical & Engineering Aspects is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.colsurfa.2018.01.012 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Drug delivery systems Type: general – SubjectFull: Hydrogen-ion concentration Type: general – SubjectFull: Caseins Type: general – SubjectFull: Surface coatings Type: general – SubjectFull: Solid dosage forms Type: general – SubjectFull: Atomic force microscopy Type: general Titles: – TitleFull: pH-responsive casein-based films and their application as functional coatings in solid dosage formulations. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Picchio, Matías L. – PersonEntity: Name: NameFull: Paredes, Alejandro J. – PersonEntity: Name: NameFull: Palma, Santiago D. – PersonEntity: Name: NameFull: Jr.Passeggi, Mario C.G. – PersonEntity: Name: NameFull: Gugliotta, Luis M. – PersonEntity: Name: NameFull: Minari, Roque J. – PersonEntity: Name: NameFull: Igarzabal, Cecilia I. Alvarez IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 03 Text: Mar2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 09277757 Numbering: – Type: volume Value: 541 Titles: – TitleFull: Colloids & Surfaces A: Physicochemical & Engineering Aspects Type: main |
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