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Integrative omics analysis of p53‐dependent regulation of metabolism.

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Title: Integrative omics analysis of p53‐dependent regulation of metabolism.
Authors: Huang, Jiajun1, Long, Ze1, Lin, Wanjun1, Liao, Xiaolin1, Xie, Ying1, Liu, Liang1 lliu@must.edu.mo, Ma, Wenzhe1 wzma@must.edu.mo
Source: FEBS Letters. Feb2018, Vol. 592 Issue 3, p380-393. 14p.
Subjects: Genetics of colon cancer, p53 antioncogene, Genetic regulation, Cell metabolism, Neoplastic cell transformation, Metabolomics
Abstract: Accumulated evidence in the last decade implies that regulation of metabolism by p53 represents a reviving mechanism vital to prevent tumorigenesis. To gain a more in‐depth understanding of metabolic regulation by baseline levels of p53, we employed both metabolomics and transcriptomics analysis with human colon cancer cell‐line HCT116 depleted of p53. Metabolomics analyses with UPLC/quadrupole time‐of‐flight mass spectrometry identified 283 significantly changed metabolites including 138 important metabolites. Transcriptomics analysis with microarray revealed 1317 differentially expressed genes. By integrated analysis of both omics data, we found nucleotides metabolism and sulfur‐related metabolism are of great importance. Our study provided a pilot comprehensive view of the metabolism regulated by p53 and suggests several potential p53 targets in metabolism for further study. [ABSTRACT FROM AUTHOR]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 127968386
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  Data: <searchLink fieldCode="DE" term="%22Genetics+of+colon+cancer%22">Genetics of colon cancer</searchLink><br /><searchLink fieldCode="DE" term="%22p53+antioncogene%22">p53 antioncogene</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+regulation%22">Genetic regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+metabolism%22">Cell metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplastic+cell+transformation%22">Neoplastic cell transformation</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolomics%22">Metabolomics</searchLink>
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  Data: Accumulated evidence in the last decade implies that regulation of metabolism by p53 represents a reviving mechanism vital to prevent tumorigenesis. To gain a more in‐depth understanding of metabolic regulation by baseline levels of p53, we employed both metabolomics and transcriptomics analysis with human colon cancer cell‐line HCT116 depleted of p53. Metabolomics analyses with UPLC/quadrupole time‐of‐flight mass spectrometry identified 283 significantly changed metabolites including 138 important metabolites. Transcriptomics analysis with microarray revealed 1317 differentially expressed genes. By integrated analysis of both omics data, we found nucleotides metabolism and sulfur‐related metabolism are of great importance. Our study provided a pilot comprehensive view of the metabolism regulated by p53 and suggests several potential p53 targets in metabolism for further study. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/1873-3468.12968
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        Text: English
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      – SubjectFull: Genetics of colon cancer
        Type: general
      – SubjectFull: p53 antioncogene
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      – SubjectFull: Genetic regulation
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      – SubjectFull: Metabolomics
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              Text: Feb2018
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              Y: 2018
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