Bibliographic Details
| Title: |
Effect of Aqueous PEG or PPG Solvents on Reaction Selectivity and Gibbs Energies. |
| Authors: |
Leininger, Neff F.1, Gainer, John L.1, Kirwan, Donald J.1 djk@virginia.edu |
| Source: |
AIChE Journal. Feb2004, Vol. 50 Issue 2, p511-517. 7p. 2 Diagrams, 1 Chart, 6 Graphs. |
| Subjects: |
Molecular weights, Polyethylene glycol, Solvents, Diels-Alder reaction, Chemical reactions, Organic solvents |
| Abstract: |
Low molecular weight polyethylene glycol (PEG 300), polypropylene glycol (PPG 425), and their aqueous solutions are investigated for use as novel, nonvolatile, environmentally friendly reaction solvents. The kinetics and selectivities of a S[subN]1 and a Diels-Alder reaction (reactions commonly used in pharmaceutical synthesis) in the polyglycol-H[sub2]O solutions are reported. Reaction rate constants and product selectivities in the polyglycol-H[sub2]O solvents were comparable to those observed in the traditional organic solvents used with these reactions. Gibbs free energy calculations show that the reactants and reaction transition states for the S[subN]1 and Diels-Alder reactions are stabilized in the presence of the polyglycol-H[sub2]O solvents. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
