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Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data.

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Title: Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data.
Authors: Velickaite, V.1 vilma.velickaite@akademiska.se, Ferreira, D.2, Cavallin, L.3, Lind, L.1, Ahlström, H.1, Kilander, L.4, Westman, E.2, Larsson, E.-M.1
Source: European Radiology. Apr2018, Vol. 28 Issue 4, p1739-1747. 9p. 1 Black and White Photograph, 4 Charts, 3 Graphs.
Subjects: Temporal lobe diseases, Cerebral atrophy, Cohort analysis, Dementia, Cognitive testing
Abstract: Objectives: To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large population-based cohort.Methods: Three hundred and ninety 75-year-old individuals were examined with magnetic resonance imaging of the brain and cognitive testing. The Scheltens's scale was used to assess visually MTA scores (0-4) in all subjects. Cognitive tests were repeated in 278 of them after 5 years. Normal MTA cut-off values were calculated based on the 10th percentile.Results: Most 75-year-old individuals had MTA score ≤2. Men had significantly higher MTA scores than women. Scores for left and average MTA were significantly higher in highly educated individuals. Abnormal MTA was associated with worse results in cognitive test and individuals with abnormal right MTA had faster cognitive decline.Conclusion: At age 75, gender and education are confounders for MTA grading. A score of ≥2 is abnormal for low-educated women and a score of ≥2.5 is abnormal for men and high-educated women. Subjects with abnormal right MTA, but normal MMSE scores had developed worse MMSE scores 5 years later.Key Points: • Gender and education are confounders for MTA grading. • We suggest cut-off values for 75-year-olds, taking gender and education into account. • Males have higher MTA scores than women. • Higher MTA scores are associated with worse cognitive performance. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data.
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  Data: <searchLink fieldCode="AR" term="%22Velickaite%2C+V%2E%22">Velickaite, V.</searchLink><relatesTo>1</relatesTo><i> vilma.velickaite@akademiska.se</i><br /><searchLink fieldCode="AR" term="%22Ferreira%2C+D%2E%22">Ferreira, D.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cavallin%2C+L%2E%22">Cavallin, L.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lind%2C+L%2E%22">Lind, L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ahlström%2C+H%2E%22">Ahlström, H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kilander%2C+L%2E%22">Kilander, L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Westman%2C+E%2E%22">Westman, E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Larsson%2C+E%2E-M%2E%22">Larsson, E.-M.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Apr2018, Vol. 28 Issue 4, p1739-1747. 9p. 1 Black and White Photograph, 4 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Temporal+lobe+diseases%22">Temporal lobe diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+atrophy%22">Cerebral atrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Dementia%22">Dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+testing%22">Cognitive testing</searchLink>
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  Data: <bold>Objectives: </bold>To find cut-off values for different medial temporal lobe atrophy (MTA) measures (right, left, average, and highest), accounting for gender and education, investigate the association with cognitive performance, and to compare with decline of cognitive function over 5 years in a large population-based cohort.<bold>Methods: </bold>Three hundred and ninety 75-year-old individuals were examined with magnetic resonance imaging of the brain and cognitive testing. The Scheltens's scale was used to assess visually MTA scores (0-4) in all subjects. Cognitive tests were repeated in 278 of them after 5 years. Normal MTA cut-off values were calculated based on the 10th percentile.<bold>Results: </bold>Most 75-year-old individuals had MTA score ≤2. Men had significantly higher MTA scores than women. Scores for left and average MTA were significantly higher in highly educated individuals. Abnormal MTA was associated with worse results in cognitive test and individuals with abnormal right MTA had faster cognitive decline.<bold>Conclusion: </bold>At age 75, gender and education are confounders for MTA grading. A score of ≥2 is abnormal for low-educated women and a score of ≥2.5 is abnormal for men and high-educated women. Subjects with abnormal right MTA, but normal MMSE scores had developed worse MMSE scores 5 years later.<bold>Key Points: </bold>• Gender and education are confounders for MTA grading. • We suggest cut-off values for 75-year-olds, taking gender and education into account. • Males have higher MTA scores than women. • Higher MTA scores are associated with worse cognitive performance. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Apr2018
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