Modeling the effect of collagen fibril alignment on ligament mechanical behavior.
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| Title: | Modeling the effect of collagen fibril alignment on ligament mechanical behavior. |
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| Authors: | Stender, Christina J.1, Rust, Evan1, Martin, Peter T.1, Neumann, Erica E.1, Brown, Raquel J.2, Lujan, Trevor J.1 trevorlujan@boisestate.edu |
| Source: | Biomechanics & Modeling in Mechanobiology. Apr2018, Vol. 17 Issue 2, p543-557. 15p. |
| Subjects: | Collagen, Confocal microscopy, Ligaments, Mechanical behavior of materials, Mechanical stress analysis |
| Abstract: | Ligament mechanical behavior is primarily regulated by fibrous networks of type I collagen. Although these fibrous networks are typically highly aligned, healthy and injured ligament can also exhibit disorganized collagen architecture. The objective of this study was to determine whether variations in the collagen fibril network between neighboring ligaments can predict observed differences in mechanical behavior. Ligament specimens from two regions of bovine fetlock joints, which either exhibited highly aligned or disorganized collagen fibril networks, were mechanically tested in uniaxial tension. Confocal microscopy and FiberFit software were used to quantify the collagen fibril dispersion and mean fibril orientation in the mechanically tested specimens. These two structural parameters served as inputs into an established hyperelastic constitutive model that accounts for a continuous distribution of planar fibril orientations. The ability of the model to predict differences in the mechanical behavior between neighboring ligaments was tested by (1) curve fitting the model parameters to the stress response of the ligament with highly aligned fibrils and then (2) using this model to predict the stress response of the ligament with disorganized fibrils by only changing the parameter values for fibril dispersion and mean fibril orientation. This study found that when using parameter values for fibril dispersion and mean fibril orientation based on confocal imaging data, the model strongly predicted the average stress response of ligaments with disorganized fibrils (R2=0.97 |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 128397952 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Modeling the effect of collagen fibril alignment on ligament mechanical behavior. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Stender%2C+Christina+J%2E%22">Stender, Christina J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rust%2C+Evan%22">Rust, Evan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Martin%2C+Peter+T%2E%22">Martin, Peter T.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Neumann%2C+Erica+E%2E%22">Neumann, Erica E.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Brown%2C+Raquel+J%2E%22">Brown, Raquel J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lujan%2C+Trevor+J%2E%22">Lujan, Trevor J.</searchLink><relatesTo>1</relatesTo><i> trevorlujan@boisestate.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Apr2018, Vol. 17 Issue 2, p543-557. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Collagen%22">Collagen</searchLink><br /><searchLink fieldCode="DE" term="%22Confocal+microscopy%22">Confocal microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Ligaments%22">Ligaments</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+stress+analysis%22">Mechanical stress analysis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Ligament mechanical behavior is primarily regulated by fibrous networks of type I collagen. Although these fibrous networks are typically highly aligned, healthy and injured ligament can also exhibit disorganized collagen architecture. The objective of this study was to determine whether variations in the collagen fibril network between neighboring ligaments can predict observed differences in mechanical behavior. Ligament specimens from two regions of bovine fetlock joints, which either exhibited highly aligned or disorganized collagen fibril networks, were mechanically tested in uniaxial tension. Confocal microscopy and FiberFit software were used to quantify the collagen fibril dispersion and mean fibril orientation in the mechanically tested specimens. These two structural parameters served as inputs into an established hyperelastic constitutive model that accounts for a continuous distribution of planar fibril orientations. The ability of the model to predict differences in the mechanical behavior between neighboring ligaments was tested by (1) curve fitting the model parameters to the stress response of the ligament with highly aligned fibrils and then (2) using this model to predict the stress response of the ligament with disorganized fibrils by only changing the parameter values for fibril dispersion and mean fibril orientation. This study found that when using parameter values for fibril dispersion and mean fibril orientation based on confocal imaging data, the model strongly predicted the average stress response of ligaments with disorganized fibrils (R2=0.97<inline-graphic></inline-graphic>); however, the model only successfully predicted the individual stress response of ligaments with disorganized fibrils in half the specimens tested. Model predictions became worse when parameters for fibril dispersion and mean fibril orientation were not based on confocal imaging data. These findings emphasize the importance of collagen fibril alignment in ligament mechanics and help advance a mechanistic understanding of fibrillar networks in healthy and injured ligament. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-017-0977-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 543 Subjects: – SubjectFull: Collagen Type: general – SubjectFull: Confocal microscopy Type: general – SubjectFull: Ligaments Type: general – SubjectFull: Mechanical behavior of materials Type: general – SubjectFull: Mechanical stress analysis Type: general Titles: – TitleFull: Modeling the effect of collagen fibril alignment on ligament mechanical behavior. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Stender, Christina J. – PersonEntity: Name: NameFull: Rust, Evan – PersonEntity: Name: NameFull: Martin, Peter T. – PersonEntity: Name: NameFull: Neumann, Erica E. – PersonEntity: Name: NameFull: Brown, Raquel J. – PersonEntity: Name: NameFull: Lujan, Trevor J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 17 – Type: issue Value: 2 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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