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A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness.

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Title: A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness.
Authors: Baur, Alexander D. J.1 alexander.baur@charite.de, Schwabe, Julia2, Rogasch, Julian3, Maxeiner, Andreas4, Penzkofer, Tobias1, Stephan, Carsten4,5, Rudl, Marc5,6, Hamm, Bernd1, Jung, Ernst-Michael7, Fischer, Thom2
Source: European Radiology. May2018, Vol. 28 Issue 5, p1949-1960. 12p. 4 Charts, 4 Graphs.
Subjects: Endorectal ultrasonography, Magnetic resonance imaging, Exocrine glands, Contrast-enhanced ultrasound, Biopsy, Prostate tumors, Cancer invasiveness, Comparative studies, Endoscopic ultrasonography, Research methodology, Medical cooperation, Prostate, Rectum, Research, Evaluation research, Predictive tests, Contrast media, Tumor grading, Diagnosis
Abstract: Introduction: Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness.Material and Methods: A post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed. The predictive values for discrimination between benign lesions, low-/intermediate- and high-grade PCa were evaluated. Results of targeted biopsy served as reference standard (benign lesions, n=51; low- and intermediate-grade PCa [Gleason grade group 1 and 2], n=22; high-grade PCa [≥ Gleason grade group 3], n=19).Results: In peripheral zone lesions of all tested CEUS parameters only time to peak (TTPCEUS) showed significant differences between benign lesions and PCa (AUC 0.65). Of all tested DCE-MRI parameters, rate constant (Kep) was the best discriminator of high-grade PCa in the whole prostate (AUC 0.83) and in peripheral zone lesions (AUC 0.89).Conclusion: DCE-MRI showed a superior performance for detection of PCa and prediction of its aggressiveness. CEUS and DCE-MRI performed better in peripheral zone lesions than in transition zone lesions.Key Points: • DCE-MRI gathers information about vascularization and capillary permeability characteristics of tissues. • DCE-MRI can detect PCa and predict its aggressiveness. • CEUS also gathers information about vascularization of tissues. • For detection of PCa and prediction of aggressiveness DCE-MRI performed superiorly. • Both imaging techniques performed better in peripheral zone lesions. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness.
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  Data: <searchLink fieldCode="AR" term="%22Baur%2C+Alexander+D%2E+J%2E%22">Baur, Alexander D. J.</searchLink><relatesTo>1</relatesTo><i> alexander.baur@charite.de</i><br /><searchLink fieldCode="AR" term="%22Schwabe%2C+Julia%22">Schwabe, Julia</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rogasch%2C+Julian%22">Rogasch, Julian</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Maxeiner%2C+Andreas%22">Maxeiner, Andreas</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Penzkofer%2C+Tobias%22">Penzkofer, Tobias</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stephan%2C+Carsten%22">Stephan, Carsten</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Rudl%2C+Marc%22">Rudl, Marc</searchLink><relatesTo>5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Hamm%2C+Bernd%22">Hamm, Bernd</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jung%2C+Ernst-Michael%22">Jung, Ernst-Michael</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Fischer%2C+Thom%22">Fischer, Thom</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. May2018, Vol. 28 Issue 5, p1949-1960. 12p. 4 Charts, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Endorectal+ultrasonography%22">Endorectal ultrasonography</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Exocrine+glands%22">Exocrine glands</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast-enhanced+ultrasound%22">Contrast-enhanced ultrasound</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate+tumors%22">Prostate tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Endoscopic+ultrasonography%22">Endoscopic ultrasonography</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate%22">Prostate</searchLink><br /><searchLink fieldCode="DE" term="%22Rectum%22">Rectum</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Predictive+tests%22">Predictive tests</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+grading%22">Tumor grading</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink>
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  Label: Abstract
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  Data: <bold>Introduction: </bold>Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness.<bold>Material and Methods: </bold>A post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed. The predictive values for discrimination between benign lesions, low-/intermediate- and high-grade PCa were evaluated. Results of targeted biopsy served as reference standard (benign lesions, n=51; low- and intermediate-grade PCa [Gleason grade group 1 and 2], n=22; high-grade PCa [≥ Gleason grade group 3], n=19).<bold>Results: </bold>In peripheral zone lesions of all tested CEUS parameters only time to peak (TTPCEUS) showed significant differences between benign lesions and PCa (AUC 0.65). Of all tested DCE-MRI parameters, rate constant (Kep) was the best discriminator of high-grade PCa in the whole prostate (AUC 0.83) and in peripheral zone lesions (AUC 0.89).<bold>Conclusion: </bold>DCE-MRI showed a superior performance for detection of PCa and prediction of its aggressiveness. CEUS and DCE-MRI performed better in peripheral zone lesions than in transition zone lesions.<bold>Key Points: </bold>• DCE-MRI gathers information about vascularization and capillary permeability characteristics of tissues. • DCE-MRI can detect PCa and predict its aggressiveness. • CEUS also gathers information about vascularization of tissues. • For detection of PCa and prediction of aggressiveness DCE-MRI performed superiorly. • Both imaging techniques performed better in peripheral zone lesions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-017-5192-2
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        Type: general
      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Exocrine glands
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      – SubjectFull: Endoscopic ultrasonography
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      – SubjectFull: Medical cooperation
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      – SubjectFull: Rectum
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