View in EDS

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance.

Saved in:
Bibliographic Details
Title: Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance.
Authors: Stone, M. Rhia L.1, Butler, Mark S.1, Phetsang, Wanida1, Cooper, Matthew A.1, Blaskovich, Mark A.T.1 m.blaskovich@uq.edu.au
Source: Trends in Biotechnology. May2018, Vol. 36 Issue 5, p523-536. 14p.
Subjects: Antibiotics, Multidrug resistance in bacteria, Chemical biology, Bacterial growth, Fluorescent antibody technique, Infection, Diagnosis
Abstract: Better understanding how multidrug-resistant (MDR) bacteria can evade current and novel antibiotics requires a better understanding of the chemical biology of antibiotic action. This necessitates using new tools and techniques to advance our knowledge of bacterial responses to antibiotics, ideally in live cells in real time, to selectively investigate bacterial growth, division, metabolism, and resistance in response to antibiotic challenge. In this review, we discuss the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms. We also examine the potential utility of such probes for real-time in vivo diagnosis of infections. [ABSTRACT FROM AUTHOR]
Copyright of Trends in Biotechnology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 129007993
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Stone%2C+M%2E+Rhia+L%2E%22">Stone, M. Rhia L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Butler%2C+Mark+S%2E%22">Butler, Mark S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Phetsang%2C+Wanida%22">Phetsang, Wanida</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cooper%2C+Matthew+A%2E%22">Cooper, Matthew A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Blaskovich%2C+Mark+A%2ET%2E%22">Blaskovich, Mark A.T.</searchLink><relatesTo>1</relatesTo><i> m.blaskovich@uq.edu.au</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Trends+in+Biotechnology%22">Trends in Biotechnology</searchLink>. May2018, Vol. 36 Issue 5, p523-536. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Antibiotics%22">Antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Multidrug+resistance+in+bacteria%22">Multidrug resistance in bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+biology%22">Chemical biology</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+growth%22">Bacterial growth</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescent+antibody+technique%22">Fluorescent antibody technique</searchLink><br /><searchLink fieldCode="DE" term="%22Infection%22">Infection</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Better understanding how multidrug-resistant (MDR) bacteria can evade current and novel antibiotics requires a better understanding of the chemical biology of antibiotic action. This necessitates using new tools and techniques to advance our knowledge of bacterial responses to antibiotics, ideally in live cells in real time, to selectively investigate bacterial growth, division, metabolism, and resistance in response to antibiotic challenge. In this review, we discuss the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms. We also examine the potential utility of such probes for real-time in vivo diagnosis of infections. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Trends in Biotechnology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=129007993
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.tibtech.2018.01.004
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 523
    Subjects:
      – SubjectFull: Antibiotics
        Type: general
      – SubjectFull: Multidrug resistance in bacteria
        Type: general
      – SubjectFull: Chemical biology
        Type: general
      – SubjectFull: Bacterial growth
        Type: general
      – SubjectFull: Fluorescent antibody technique
        Type: general
      – SubjectFull: Infection
        Type: general
      – SubjectFull: Diagnosis
        Type: general
    Titles:
      – TitleFull: Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Stone, M. Rhia L.
      – PersonEntity:
          Name:
            NameFull: Butler, Mark S.
      – PersonEntity:
          Name:
            NameFull: Phetsang, Wanida
      – PersonEntity:
          Name:
            NameFull: Cooper, Matthew A.
      – PersonEntity:
          Name:
            NameFull: Blaskovich, Mark A.T.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 01677799
          Numbering:
            – Type: volume
              Value: 36
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Trends in Biotechnology
              Type: main
ResultId 1