Bibliographic Details
| Title: |
“Metal-free” synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives. |
| Authors: |
Kumar, B. Senthil1, Gadakh, Sunita1, Sudalai, Arumugam1 a.sudalai@ncl.res.in |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2018, Vol. 59 Issue 24, p2365-2367. 3p. |
| Subjects: |
Triazoles synthesis, Azidation, Ring formation (Chemistry), Aromatization, Ethyl acrylate, Chemical derivatives |
| Abstract: |
An efficient “one-pot” method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives on treatment with NaN 3 in DMF under mild conditions. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
