Lipid-mediated signals that regulate mitochondrial biology.
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| Title: | Lipid-mediated signals that regulate mitochondrial biology. |
|---|---|
| Authors: | Rutter, Jared P.1, Nielson, Jason R.1,2 |
| Source: | Journal of Biological Chemistry. 5/18/2018, Vol. 293 Issue 20, p7517-7521. 6p. |
| Subjects: | Lipids, Biological membranes, Phospholipids, Sphingolipids, Electron transport, Homeostasis |
| Abstract: | For decades, lipids were assumed to fulfill roles only in energy storage and membrane structure. Recent studies have discovered critical roles for phospholipids, sphingolipids, and sterols in many cellular pathways, including cell signaling and transcriptional regulation. Frequently, lipids from these various classes work together to achieve defined cellular outcomes. Specific mitochondrial lipids are critical for proper assembly of the electron transport chain complexes and for effective responses to mitochondrial damage, including maintenance of mitochondrial protein homeostasis, regulation of mitophagy, and induction of apoptosis. In this Minireview, we will primarily focus on mitochondrial lipid signaling mediated by lipid-protein interactions. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 129696373 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lipid-mediated signals that regulate mitochondrial biology. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rutter%2C+Jared+P%2E%22">Rutter, Jared P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nielson%2C+Jason+R%2E%22">Nielson, Jason R.</searchLink><relatesTo>1,2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Biological+Chemistry%22">Journal of Biological Chemistry</searchLink>. 5/18/2018, Vol. 293 Issue 20, p7517-7521. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lipids%22">Lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+membranes%22">Biological membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Phospholipids%22">Phospholipids</searchLink><br /><searchLink fieldCode="DE" term="%22Sphingolipids%22">Sphingolipids</searchLink><br /><searchLink fieldCode="DE" term="%22Electron+transport%22">Electron transport</searchLink><br /><searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: For decades, lipids were assumed to fulfill roles only in energy storage and membrane structure. Recent studies have discovered critical roles for phospholipids, sphingolipids, and sterols in many cellular pathways, including cell signaling and transcriptional regulation. Frequently, lipids from these various classes work together to achieve defined cellular outcomes. Specific mitochondrial lipids are critical for proper assembly of the electron transport chain complexes and for effective responses to mitochondrial damage, including maintenance of mitochondrial protein homeostasis, regulation of mitophagy, and induction of apoptosis. In this Minireview, we will primarily focus on mitochondrial lipid signaling mediated by lipid-protein interactions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=129696373 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1074/jbc.R117.001655 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 7517 Subjects: – SubjectFull: Lipids Type: general – SubjectFull: Biological membranes Type: general – SubjectFull: Phospholipids Type: general – SubjectFull: Sphingolipids Type: general – SubjectFull: Electron transport Type: general – SubjectFull: Homeostasis Type: general Titles: – TitleFull: Lipid-mediated signals that regulate mitochondrial biology. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rutter, Jared P. – PersonEntity: Name: NameFull: Nielson, Jason R. IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 05 Text: 5/18/2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 00219258 Numbering: – Type: volume Value: 293 – Type: issue Value: 20 Titles: – TitleFull: Journal of Biological Chemistry Type: main |
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