Lipid-mediated signals that regulate mitochondrial biology.
Saved in:
| Title: | Lipid-mediated signals that regulate mitochondrial biology. |
|---|---|
| Authors: | Rutter, Jared P.1, Nielson, Jason R.1,2 |
| Source: | Journal of Biological Chemistry. 5/18/2018, Vol. 293 Issue 20, p7517-7521. 6p. |
| Subjects: | Lipids, Biological membranes, Phospholipids, Sphingolipids, Electron transport, Homeostasis |
| Abstract: | For decades, lipids were assumed to fulfill roles only in energy storage and membrane structure. Recent studies have discovered critical roles for phospholipids, sphingolipids, and sterols in many cellular pathways, including cell signaling and transcriptional regulation. Frequently, lipids from these various classes work together to achieve defined cellular outcomes. Specific mitochondrial lipids are critical for proper assembly of the electron transport chain complexes and for effective responses to mitochondrial damage, including maintenance of mitochondrial protein homeostasis, regulation of mitophagy, and induction of apoptosis. In this Minireview, we will primarily focus on mitochondrial lipid signaling mediated by lipid-protein interactions. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
Be the first to leave a comment!
