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Modeling the performance of carrier-based dry powder inhalation formulations: Where are we, and how to get there?

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Title: Modeling the performance of carrier-based dry powder inhalation formulations: Where are we, and how to get there?
Authors: Elsayed, Mustafa M.A.1,2 mustafa.elsayed@alexpharmres.com, Shalash, Ahmed O.3
Source: Journal of Controlled Release. Jun2018, Vol. 279, p251-261. 11p.
Subjects: Pharmaceutical powders, Drug interactions, Drug development, Drug carriers, Microstructure
Abstract: Development of carrier-based dry powder inhalation formulations follows till date empirical approaches. This is mainly underlain by numerousness of interplaying determinants of performance and complexity of involved interactions. Mathematical modeling helps elucidate such interactions and aids rational development of formulations. This article provides a critical overview of attempts made to model the performance of carrier-based dry powder inhalation formulations. The complex dependence of the performance on formulation properties is comprehensively discussed. A potential microstructure-based model is ultimately introduced. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 129790204
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Modeling the performance of carrier-based dry powder inhalation formulations: Where are we, and how to get there?
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  Data: <searchLink fieldCode="AR" term="%22Elsayed%2C+Mustafa+M%2EA%2E%22">Elsayed, Mustafa M.A.</searchLink><relatesTo>1,2</relatesTo><i> mustafa.elsayed@alexpharmres.com</i><br /><searchLink fieldCode="AR" term="%22Shalash%2C+Ahmed+O%2E%22">Shalash, Ahmed O.</searchLink><relatesTo>3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Jun2018, Vol. 279, p251-261. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Pharmaceutical+powders%22">Pharmaceutical powders</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+interactions%22">Drug interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+development%22">Drug development</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+carriers%22">Drug carriers</searchLink><br /><searchLink fieldCode="DE" term="%22Microstructure%22">Microstructure</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Development of carrier-based dry powder inhalation formulations follows till date empirical approaches. This is mainly underlain by numerousness of interplaying determinants of performance and complexity of involved interactions. Mathematical modeling helps elucidate such interactions and aids rational development of formulations. This article provides a critical overview of attempts made to model the performance of carrier-based dry powder inhalation formulations. The complex dependence of the performance on formulation properties is comprehensively discussed. A potential microstructure-based model is ultimately introduced. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/j.jconrel.2018.03.020
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 251
    Subjects:
      – SubjectFull: Pharmaceutical powders
        Type: general
      – SubjectFull: Drug interactions
        Type: general
      – SubjectFull: Drug development
        Type: general
      – SubjectFull: Drug carriers
        Type: general
      – SubjectFull: Microstructure
        Type: general
    Titles:
      – TitleFull: Modeling the performance of carrier-based dry powder inhalation formulations: Where are we, and how to get there?
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            NameFull: Elsayed, Mustafa M.A.
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            NameFull: Shalash, Ahmed O.
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              M: 06
              Text: Jun2018
              Type: published
              Y: 2018
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              Value: 279
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            – TitleFull: Journal of Controlled Release
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