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Stereotactic body radiotherapy (SBRT) for multiple pulmonary oligometastases: Analysis of number and timing of repeat SBRT as impact factors on treatment safety and efficacy.

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Title: Stereotactic body radiotherapy (SBRT) for multiple pulmonary oligometastases: Analysis of number and timing of repeat SBRT as impact factors on treatment safety and efficacy.
Authors: Klement, R.J.1, Hoerner-Rieber, J.2,3, Adebahr, S.4,5,6, Andratschke, N.7, Blanck, O.8, Boda-Heggemann, J.9, Duma, M.10, Eble, M.J.11, Eich, H.C.12, Flentje, M.13, Gerum, S.14, Hass, P.15, Henkenberens, C.16, Hildebrandt, G.17, Imhoff, D.18, Kahl, K.H.19, Klass, N.D.20, Krempien, R.21, Lohaus, F.5,6,22,23, Petersen, C.24
Source: Radiotherapy & Oncology. May2018, Vol. 127 Issue 2, p246-252. 7p.
Subjects: Lung disease treatment, Stereotactic radiotherapy, Cancer treatment, Metastasis, Logistic regression analysis, Death rate
Abstract: Background Stereotactic body radiotherapy (SBRT) for oligometastatic disease is characterized by an excellent safety profile; however, experiences are mostly based on treatment of one single metastasis. It was the aim of this study to evaluate safety and efficacy of SBRT for multiple pulmonary metastases. Patients and methods This study is based on a retrospective database of the DEGRO stereotactic working group, consisting of 637 patients with 858 treatments. Cox regression and logistic regression were used to analyze the association between the number of SBRT treatments or the number and the timing of repeat SBRT courses with overall survival (OS) and the risk of early death. Results Out of 637 patients, 145 patients were treated for multiple pulmonary metastases; 88 patients received all SBRT treatments within one month whereas 57 patients were treated with repeat SBRT separated by at least one month. Median OS for the total patient population was 23.5 months and OS was not significantly influenced by the overall number of SBRT treatments or the number and timing of repeat SBRT courses. The risk of early death within 3 and 6 months was not increased in patients treated with multiple SBRT treatments, and no grade 4 or grade 5 toxicity was observed in these patients. Conclusions In appropriately selected patients, synchronous SBRT for multiple pulmonary oligometastases and repeat SBRT may have a comparable safety and efficacy profile compared to SBRT for one single oligometastasis. [ABSTRACT FROM AUTHOR]
Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Stereotactic body radiotherapy (SBRT) for multiple pulmonary oligometastases: Analysis of number and timing of repeat SBRT as impact factors on treatment safety and efficacy.
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  Data: <searchLink fieldCode="AR" term="%22Klement%2C+R%2EJ%2E%22">Klement, R.J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hoerner-Rieber%2C+J%2E%22">Hoerner-Rieber, J.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Adebahr%2C+S%2E%22">Adebahr, S.</searchLink><relatesTo>4,5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Andratschke%2C+N%2E%22">Andratschke, N.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Blanck%2C+O%2E%22">Blanck, O.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Boda-Heggemann%2C+J%2E%22">Boda-Heggemann, J.</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Duma%2C+M%2E%22">Duma, M.</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Eble%2C+M%2EJ%2E%22">Eble, M.J.</searchLink><relatesTo>11</relatesTo><br /><searchLink fieldCode="AR" term="%22Eich%2C+H%2EC%2E%22">Eich, H.C.</searchLink><relatesTo>12</relatesTo><br /><searchLink fieldCode="AR" term="%22Flentje%2C+M%2E%22">Flentje, M.</searchLink><relatesTo>13</relatesTo><br /><searchLink fieldCode="AR" term="%22Gerum%2C+S%2E%22">Gerum, S.</searchLink><relatesTo>14</relatesTo><br /><searchLink fieldCode="AR" term="%22Hass%2C+P%2E%22">Hass, P.</searchLink><relatesTo>15</relatesTo><br /><searchLink fieldCode="AR" term="%22Henkenberens%2C+C%2E%22">Henkenberens, C.</searchLink><relatesTo>16</relatesTo><br /><searchLink fieldCode="AR" term="%22Hildebrandt%2C+G%2E%22">Hildebrandt, G.</searchLink><relatesTo>17</relatesTo><br /><searchLink fieldCode="AR" term="%22Imhoff%2C+D%2E%22">Imhoff, D.</searchLink><relatesTo>18</relatesTo><br /><searchLink fieldCode="AR" term="%22Kahl%2C+K%2EH%2E%22">Kahl, K.H.</searchLink><relatesTo>19</relatesTo><br /><searchLink fieldCode="AR" term="%22Klass%2C+N%2ED%2E%22">Klass, N.D.</searchLink><relatesTo>20</relatesTo><br /><searchLink fieldCode="AR" term="%22Krempien%2C+R%2E%22">Krempien, R.</searchLink><relatesTo>21</relatesTo><br /><searchLink fieldCode="AR" term="%22Lohaus%2C+F%2E%22">Lohaus, F.</searchLink><relatesTo>5,6,22,23</relatesTo><br /><searchLink fieldCode="AR" term="%22Petersen%2C+C%2E%22">Petersen, C.</searchLink><relatesTo>24</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Radiotherapy+%26+Oncology%22">Radiotherapy & Oncology</searchLink>. May2018, Vol. 127 Issue 2, p246-252. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Lung+disease+treatment%22">Lung disease treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Stereotactic+radiotherapy%22">Stereotactic radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Metastasis%22">Metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Death+rate%22">Death rate</searchLink>
– Name: Abstract
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  Data: Background Stereotactic body radiotherapy (SBRT) for oligometastatic disease is characterized by an excellent safety profile; however, experiences are mostly based on treatment of one single metastasis. It was the aim of this study to evaluate safety and efficacy of SBRT for multiple pulmonary metastases. Patients and methods This study is based on a retrospective database of the DEGRO stereotactic working group, consisting of 637 patients with 858 treatments. Cox regression and logistic regression were used to analyze the association between the number of SBRT treatments or the number and the timing of repeat SBRT courses with overall survival (OS) and the risk of early death. Results Out of 637 patients, 145 patients were treated for multiple pulmonary metastases; 88 patients received all SBRT treatments within one month whereas 57 patients were treated with repeat SBRT separated by at least one month. Median OS for the total patient population was 23.5 months and OS was not significantly influenced by the overall number of SBRT treatments or the number and timing of repeat SBRT courses. The risk of early death within 3 and 6 months was not increased in patients treated with multiple SBRT treatments, and no grade 4 or grade 5 toxicity was observed in these patients. Conclusions In appropriately selected patients, synchronous SBRT for multiple pulmonary oligometastases and repeat SBRT may have a comparable safety and efficacy profile compared to SBRT for one single oligometastasis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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