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Gene editing and genetic engineering approaches for advanced probiotics: A review.

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Title: Gene editing and genetic engineering approaches for advanced probiotics: A review.
Authors: Yadav, Ruby1, Kumar, Vishal1, Baweja, Mehak1, Shukla, Pratyoosh1 pratyoosh.shukla@gmail.com
Source: Critical Reviews in Food Science & Nutrition. 2018, Vol. 58 Issue 10, p1735-1746. 12p.
Subjects: Genome editing, Genetic engineering, Probiotics, Gut microbiota, Systems biology, Bacterial metabolism, Bacteria
Abstract: The applications of probiotics are significant and thus resulted in need of genome analysis of probiotic strains. Various omics methods and systems biology approaches enables us to understand and optimize the metabolic processes. These techniques have increased the researcher's attention towards gut microbiome and provided a new source for the revelation of uncharacterized biosynthetic pathways which enables novel metabolic engineering approaches. In recent years, the broad and quantitative analysis of modified strains relies on systems biology tools such as in silico design which are commonly used methods for improving strain performance. The genetic manipulation of probiotic microorganisms is crucial for defining their role in intestinal microbiota and exploring their beneficial properties. This review describes an overview of gene editing and systems biology approaches, highlighting the advent of omics methods which allows the study of new routes for studying probiotic bacteria. We have also summarized gene editing tools like TALEN, ZFNs and CRISPR-Cas that edits or cleave the specific target DNA. Furthermore, in this review an overview of proposed design of advanced customized probiotic is also hypothesized to improvise the probiotics. [ABSTRACT FROM AUTHOR]
Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Gene editing and genetic engineering approaches for advanced probiotics: A review.
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  Data: <searchLink fieldCode="AR" term="%22Yadav%2C+Ruby%22">Yadav, Ruby</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kumar%2C+Vishal%22">Kumar, Vishal</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Baweja%2C+Mehak%22">Baweja, Mehak</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shukla%2C+Pratyoosh%22">Shukla, Pratyoosh</searchLink><relatesTo>1</relatesTo><i> pratyoosh.shukla@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Critical+Reviews+in+Food+Science+%26+Nutrition%22">Critical Reviews in Food Science & Nutrition</searchLink>. 2018, Vol. 58 Issue 10, p1735-1746. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Genome+editing%22">Genome editing</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+engineering%22">Genetic engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Probiotics%22">Probiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Systems+biology%22">Systems biology</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+metabolism%22">Bacterial metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Bacteria%22">Bacteria</searchLink>
– Name: Abstract
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  Data: The applications of probiotics are significant and thus resulted in need of genome analysis of probiotic strains. Various omics methods and systems biology approaches enables us to understand and optimize the metabolic processes. These techniques have increased the researcher's attention towards gut microbiome and provided a new source for the revelation of uncharacterized biosynthetic pathways which enables novel metabolic engineering approaches. In recent years, the broad and quantitative analysis of modified strains relies on systems biology tools such as in silico design which are commonly used methods for improving strain performance. The genetic manipulation of probiotic microorganisms is crucial for defining their role in intestinal microbiota and exploring their beneficial properties. This review describes an overview of gene editing and systems biology approaches, highlighting the advent of omics methods which allows the study of new routes for studying probiotic bacteria. We have also summarized gene editing tools like TALEN, ZFNs and CRISPR-Cas that edits or cleave the specific target DNA. Furthermore, in this review an overview of proposed design of advanced customized probiotic is also hypothesized to improvise the probiotics. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=130021258
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1080/10408398.2016.1274877
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 1735
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      – SubjectFull: Genome editing
        Type: general
      – SubjectFull: Genetic engineering
        Type: general
      – SubjectFull: Probiotics
        Type: general
      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Systems biology
        Type: general
      – SubjectFull: Bacterial metabolism
        Type: general
      – SubjectFull: Bacteria
        Type: general
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      – TitleFull: Gene editing and genetic engineering approaches for advanced probiotics: A review.
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            NameFull: Kumar, Vishal
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            NameFull: Baweja, Mehak
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            NameFull: Shukla, Pratyoosh
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              Text: 2018
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