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Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways.

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Title: Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways.
Authors: Zhang, Yi1, Gu, WenLong2, Duan, LiQin2, Zhu, Hong1, Wang, HongYun1, Wang, Jing2, Sun, Jian1 xzsunjian@jaas.ac.cn, Niu, FuXiang1 niufuxiang@sina.com
Source: Journal of Food Biochemistry. Jun2018, Vol. 42 Issue 3, p1-1. 11p.
Subjects: Dietary fiber, Sweet potatoes, Kidney diseases, Oxidative stress, Laboratory mice
Abstract: Abstract: Dietary fiber (DF) is the main component of sweet potato residue, which has a variety of health benefits. However, the preventive effect of DF from sweet potato on lead (Pb)‐induced renal injury remains unclear. This study identified the proximate composition and chemical components of DF extracted by ultrasound‐assisted enzymatic hydrolysis. The administration of ordinary dietary fiber (ODF) and high‐soluble dietary fiber (HSDF) decreased the blood and kidney Pb concentrations of Pb‐exposed mice. Moreover, profound Pb‐induced elevations of reactive oxygen species, malondialdehyde level, and depletion of intracellular glutathione level in kidney were suppressed by treatment with HSDF. Compared to the ODF group, HSDF activated AMP‐activated protein kinase (AMPK)/silent information regulator T1 (SIRT1)/peroxisome proliferator‐activated receptor‐γ coactivator 1α (PGC1α) signaling in kidney, which directly regulates superoxide dismutase (SOD) and nuclear respiratory factors (NRF1)/mitochondrial transcription factor A (TFAM). In conclusion, HSDF supplementation ameliorates Pb‐induced renal injury by inhibiting oxidative stress. Practical applications: In China, sweet potato residue is discarded as waste, which causes environmental pollution. Sweet potato residue can be a cheap and widely available resource of DF, which was extracted by ultrasound‐assisted enzymatic hydrolysis. This study provides biological evidence that supports the use of DF from sweet potato to prevent Pb accumulation and protect the kidney, thereby indicating that DF has a great potential to be used as natural Pb‐excreting agent and functional ingredient in food products. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Yi%22">Zhang, Yi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gu%2C+WenLong%22">Gu, WenLong</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Duan%2C+LiQin%22">Duan, LiQin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Hong%22">Zhu, Hong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+HongYun%22">Wang, HongYun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+Jing%22">Wang, Jing</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sun%2C+Jian%22">Sun, Jian</searchLink><relatesTo>1</relatesTo><i> xzsunjian@jaas.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Niu%2C+FuXiang%22">Niu, FuXiang</searchLink><relatesTo>1</relatesTo><i> niufuxiang@sina.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. Jun2018, Vol. 42 Issue 3, p1-1. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Dietary+fiber%22">Dietary fiber</searchLink><br /><searchLink fieldCode="DE" term="%22Sweet+potatoes%22">Sweet potatoes</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+diseases%22">Kidney diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Dietary fiber (DF) is the main component of sweet potato residue, which has a variety of health benefits. However, the preventive effect of DF from sweet potato on lead (Pb)‐induced renal injury remains unclear. This study identified the proximate composition and chemical components of DF extracted by ultrasound‐assisted enzymatic hydrolysis. The administration of ordinary dietary fiber (ODF) and high‐soluble dietary fiber (HSDF) decreased the blood and kidney Pb concentrations of Pb‐exposed mice. Moreover, profound Pb‐induced elevations of reactive oxygen species, malondialdehyde level, and depletion of intracellular glutathione level in kidney were suppressed by treatment with HSDF. Compared to the ODF group, HSDF activated AMP‐activated protein kinase (AMPK)/silent information regulator T1 (SIRT1)/peroxisome proliferator‐activated receptor‐γ coactivator 1α (PGC1α) signaling in kidney, which directly regulates superoxide dismutase (SOD) and nuclear respiratory factors (NRF1)/mitochondrial transcription factor A (TFAM). In conclusion, HSDF supplementation ameliorates Pb‐induced renal injury by inhibiting oxidative stress. Practical applications: In China, sweet potato residue is discarded as waste, which causes environmental pollution. Sweet potato residue can be a cheap and widely available resource of DF, which was extracted by ultrasound‐assisted enzymatic hydrolysis. This study provides biological evidence that supports the use of DF from sweet potato to prevent Pb accumulation and protect the kidney, thereby indicating that DF has a great potential to be used as natural Pb‐excreting agent and functional ingredient in food products. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/jfbc.12513
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      – Code: eng
        Text: English
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        PageCount: 11
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      – SubjectFull: Dietary fiber
        Type: general
      – SubjectFull: Sweet potatoes
        Type: general
      – SubjectFull: Kidney diseases
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Laboratory mice
        Type: general
    Titles:
      – TitleFull: Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways.
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            NameFull: Zhang, Yi
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            NameFull: Gu, WenLong
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            NameFull: Duan, LiQin
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            NameFull: Wang, Jing
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            – D: 01
              M: 06
              Text: Jun2018
              Type: published
              Y: 2018
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