In vivo mimicking model for solid tumor towards hydromechanics of tissue deformation and creation of necrosis.
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| Title: | In vivo mimicking model for solid tumor towards hydromechanics of tissue deformation and creation of necrosis. |
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| Authors: | Dey, Bibaswan1,2 bibaswandey.a@ktr.srmuniv.ac.in, Sekhar, G. P. Raja2, Mukhopadhyay, Sourav Kanti3 |
| Source: | Journal of Biological Physics. Sep2018, Vol. 44 Issue 3, p361-400. 40p. |
| Subjects: | Tumors, Fluid mechanics, Necrosis, Extracellular fluid, Peclet number |
| Abstract: | The present work addresses transvascular and interstitial fluid transport inside a solid tumor surrounded by normal tissue (close to an in vivo mimicking setup). In general, biological tissues behave like a soft porous material and show mechanical behavior towards the fluid motion through the interstitial space. In general, forces like viscous drag that are associated with the fluid flow may compress the tissue material. On the macroscopic level, we try to model the motion of fluids and macromolecules through the interstitial space of solid tumor and the normal tissue layer. The transvascular fluid transport is assumed to be governed by modified Starling’s law. The poroelastohydrodynamics (interstitial hydrodynamics and the deformation of tissue material) inside the tumor and normal tissue regions is modeled using linearized biphasic mixture theory. Correspondingly, the velocity distribution of fluid is coupled to the displacement field of the solid phase (mainly cellular phase and extracellular matrix) in both the normal and tumor tissue regions. The corresponding velocity field is used within the transport reaction equation for fluids and macromolecules through interstitial space to get the overall solute (e.g., nutrients, drug, and other macromolecules) distribution. This study justifies that the presence of the normal tissue layer plays a significant role in delaying/assisting necrosis inside the tumor tissue. It is observed that the exchange process of fluids and macromolecules across the interface of the tumor and normal tissue affects the effectiveness factor corresponding to the tumor tissue. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Biological Physics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 131151877 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In vivo mimicking model for solid tumor towards hydromechanics of tissue deformation and creation of necrosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dey%2C+Bibaswan%22">Dey, Bibaswan</searchLink><relatesTo>1,2</relatesTo><i> bibaswandey.a@ktr.srmuniv.ac.in</i><br /><searchLink fieldCode="AR" term="%22Sekhar%2C+G%2E+P%2E+Raja%22">Sekhar, G. P. Raja</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Mukhopadhyay%2C+Sourav+Kanti%22">Mukhopadhyay, Sourav Kanti</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Biological+Physics%22">Journal of Biological Physics</searchLink>. Sep2018, Vol. 44 Issue 3, p361-400. 40p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tumors%22">Tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Fluid+mechanics%22">Fluid mechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Necrosis%22">Necrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+fluid%22">Extracellular fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Peclet+number%22">Peclet number</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The present work addresses transvascular and interstitial fluid transport inside a solid tumor surrounded by normal tissue (close to an in vivo mimicking setup). In general, biological tissues behave like a soft porous material and show mechanical behavior towards the fluid motion through the interstitial space. In general, forces like viscous drag that are associated with the fluid flow may compress the tissue material. On the macroscopic level, we try to model the motion of fluids and macromolecules through the interstitial space of solid tumor and the normal tissue layer. The transvascular fluid transport is assumed to be governed by modified Starling’s law. The poroelastohydrodynamics (interstitial hydrodynamics and the deformation of tissue material) inside the tumor and normal tissue regions is modeled using linearized biphasic mixture theory. Correspondingly, the velocity distribution of fluid is coupled to the displacement field of the solid phase (mainly cellular phase and extracellular matrix) in both the normal and tumor tissue regions. The corresponding velocity field is used within the transport reaction equation for fluids and macromolecules through interstitial space to get the overall solute (e.g., nutrients, drug, and other macromolecules) distribution. This study justifies that the presence of the normal tissue layer plays a significant role in delaying/assisting necrosis inside the tumor tissue. It is observed that the exchange process of fluids and macromolecules across the interface of the tumor and normal tissue affects the effectiveness factor corresponding to the tumor tissue. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Biological Physics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10867-018-9496-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 40 StartPage: 361 Subjects: – SubjectFull: Tumors Type: general – SubjectFull: Fluid mechanics Type: general – SubjectFull: Necrosis Type: general – SubjectFull: Extracellular fluid Type: general – SubjectFull: Peclet number Type: general Titles: – TitleFull: In vivo mimicking model for solid tumor towards hydromechanics of tissue deformation and creation of necrosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dey, Bibaswan – PersonEntity: Name: NameFull: Sekhar, G. P. Raja – PersonEntity: Name: NameFull: Mukhopadhyay, Sourav Kanti IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 00920606 Numbering: – Type: volume Value: 44 – Type: issue Value: 3 Titles: – TitleFull: Journal of Biological Physics Type: main |
| ResultId | 1 |
