Non-enhanced Pattern on Contrast-Enhanced Ultrasound in the Local Efficacy Assessment of Irreversible Electroporation Ablation of Pancreatic Adenocarcinoma.
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| Title: | Non-enhanced Pattern on Contrast-Enhanced Ultrasound in the Local Efficacy Assessment of Irreversible Electroporation Ablation of Pancreatic Adenocarcinoma. |
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| Authors: | Lin, Manxia1, Xie, Xiaoyan1, Xu, Ming1, Feng, Shiting2, Tian, Wenshuo1, Zhuang, Bowen1, Su, Liya1, Ye, Jieyi1, Lin, Jinhua1, Liang, Ping3, Yu, Jie3, Kuang, Ming1,4 kuangm@mail.sysu.edu.cn |
| Source: | Ultrasound in Medicine & Biology. Sep2018, Vol. 44 Issue 9, p1986-1995. 10p. |
| Subjects: | Ultrasonic imaging, Electroporation, Adenocarcinoma, Pancreatic cancer diagnosis, Diagnosis, Patients |
| Abstract: | The objective was to evaluate the diagnostic value of contrast-enhanced ultrasound in the assessment of the local efficacy after irreversible electroporation (IRE) ablation of pancreatic adenocarcinoma 1 mo after ablation. Fifteen patients with pancreatic adenocarcinoma were treated with IRE and then examined by contrast-enhanced ultrasound 1 mo after ablation. The contrast agent was SonoVue. Technical efficacy was assessed at 3 mo after IRE and classified as technical efficiency (TE) and technical inefficiency (TIE). Diagnostic performance was analyzed using a receiver operating characteristic curve. Ten patients were considered as having TE, and five, TIE. Complete non-enhancement was observed in seven ablation zones (70.0%) in the TE group, and peripheral heterogeneous enhancement, in all five ablation zones (100.0%) in the TIE group. The non-enhancement pattern differed significantly between the TE and TIE groups (p = 0.026), with significant correlation with technical efficacy (p = 0.007). The area under the receiver operating characteristic curve was 0.85 (p = 0.008, 95% confidence interval: 0.65-1.05). A non-enhancement pattern using contrast-enhanced ultrasound was useful in the assessment of local efficacy after IRE ablation of pancreatic adenocarcinoma. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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