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Characterization of Skeletal Muscle Strain Lesion Induced by Stretching in Rats: Effects of Laser Photobiomodulation.

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Title: Characterization of Skeletal Muscle Strain Lesion Induced by Stretching in Rats: Effects of Laser Photobiomodulation.
Authors: Ramos, Luciano1, Marcos, Rodrigo Labat2, Torres-Silva, Romildo3, Pallota, Rodney Capp2, Magacho, Tatiana1, Mafra, Fernando Francisco Pazello3, Macedo, Michel Monteiro3, Carvalho, Rodrigo Leal de Paiva4, Bjordal, Jan Magnus5, Lopes-Martins, Rodrigo Alvaro B.6 ralopesmartins@gmail.com
Source: Photomedicine & Laser Surgery. Sep2018, Vol. 36 Issue 9, p460-467. 8p.
Subjects: Skeletal muscle physiology, Exercise physiology, Laser therapy, Cytokines, Laboratory rats
Abstract: Background: Unusual and exhaustive physical exercise can lead to muscle lesions depending on the type of contraction, intensity, duration, age, and level of conditioning. Different therapies have been proposed to prevent or reduce exercise-induced muscle damage. Objective: In this study, we investigate the effects of low-level laser therapy on skeletal muscle strain in an experimental model in rats. Materials and methods: Male Wistar rats (200 g) were used. The animals were randomized into groups of six animals. We performed tibialis muscle elongation using a previously described protocol. The animals were anesthetized and submitted to passive stretching of the anterior tibial muscle attached to a weight corresponding to 150% of the body mass of the animal for 20 min, rested for 3 min, and received a second traction for 20 min. The cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-10, edema, and C-reactive protein (CRP) levels were determined in the tibialis anterior muscle. Results: Plasma extravasation of groups treated with different doses of laser energy, lesion +1 J (2.61 ± 0.46), lesion +3 J (2.33 ± 0.13), lesion +6 J (2.92 ± 0.91), and lesion +9 J (2.80 ± 0.55), shows a significant reduction of extravasation when compared with the injury group (5.46 ± 1.09). Laser therapy was able to significantly reduce CRP and cytokine levels (TNF-α, IL-1β, IL-6, and IL-10). Conclusions: Laser photobiomodulation reduced skeletal muscle edema as well as cytokines and CRP, leading to a significant reduction in inflammatory markers. [ABSTRACT FROM AUTHOR]
Copyright of Photomedicine & Laser Surgery is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Label: Title
  Group: Ti
  Data: Characterization of Skeletal Muscle Strain Lesion Induced by Stretching in Rats: Effects of Laser Photobiomodulation.
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  Data: <searchLink fieldCode="AR" term="%22Ramos%2C+Luciano%22">Ramos, Luciano</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Marcos%2C+Rodrigo+Labat%22">Marcos, Rodrigo Labat</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Torres-Silva%2C+Romildo%22">Torres-Silva, Romildo</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Pallota%2C+Rodney+Capp%22">Pallota, Rodney Capp</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Magacho%2C+Tatiana%22">Magacho, Tatiana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mafra%2C+Fernando+Francisco+Pazello%22">Mafra, Fernando Francisco Pazello</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Macedo%2C+Michel+Monteiro%22">Macedo, Michel Monteiro</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Carvalho%2C+Rodrigo+Leal+de+Paiva%22">Carvalho, Rodrigo Leal de Paiva</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Bjordal%2C+Jan+Magnus%22">Bjordal, Jan Magnus</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Lopes-Martins%2C+Rodrigo+Alvaro+B%2E%22">Lopes-Martins, Rodrigo Alvaro B.</searchLink><relatesTo>6</relatesTo><i> ralopesmartins@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Photomedicine+%26+Laser+Surgery%22">Photomedicine & Laser Surgery</searchLink>. Sep2018, Vol. 36 Issue 9, p460-467. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Skeletal+muscle+physiology%22">Skeletal muscle physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Exercise+physiology%22">Exercise physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+therapy%22">Laser therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Unusual and exhaustive physical exercise can lead to muscle lesions depending on the type of contraction, intensity, duration, age, and level of conditioning. Different therapies have been proposed to prevent or reduce exercise-induced muscle damage. Objective: In this study, we investigate the effects of low-level laser therapy on skeletal muscle strain in an experimental model in rats. Materials and methods: Male Wistar rats (200 g) were used. The animals were randomized into groups of six animals. We performed tibialis muscle elongation using a previously described protocol. The animals were anesthetized and submitted to passive stretching of the anterior tibial muscle attached to a weight corresponding to 150% of the body mass of the animal for 20 min, rested for 3 min, and received a second traction for 20 min. The cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-10, edema, and C-reactive protein (CRP) levels were determined in the tibialis anterior muscle. Results: Plasma extravasation of groups treated with different doses of laser energy, lesion +1 J (2.61 ± 0.46), lesion +3 J (2.33 ± 0.13), lesion +6 J (2.92 ± 0.91), and lesion +9 J (2.80 ± 0.55), shows a significant reduction of extravasation when compared with the injury group (5.46 ± 1.09). Laser therapy was able to significantly reduce CRP and cytokine levels (TNF-α, IL-1β, IL-6, and IL-10). Conclusions: Laser photobiomodulation reduced skeletal muscle edema as well as cytokines and CRP, leading to a significant reduction in inflammatory markers. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Photomedicine & Laser Surgery is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1089/pho.2018.4473
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 460
    Subjects:
      – SubjectFull: Skeletal muscle physiology
        Type: general
      – SubjectFull: Exercise physiology
        Type: general
      – SubjectFull: Laser therapy
        Type: general
      – SubjectFull: Cytokines
        Type: general
      – SubjectFull: Laboratory rats
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      – TitleFull: Characterization of Skeletal Muscle Strain Lesion Induced by Stretching in Rats: Effects of Laser Photobiomodulation.
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              Text: Sep2018
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