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Breast Cancer, Secondary Breast Cancers in Childhood Cancer Male Survivors-Characteristics and Risks.

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Bibliographic Details
Title:	Breast Cancer, Secondary Breast Cancers in Childhood Cancer Male Survivors-Characteristics and Risks.
Authors:	Demoor-Goldschmidt, Charlotte^1,2, Allodji, Rodrigue S.^1,2, Jackson, Angela^1,2, Vu-Bezin, Giao^1,2, Souchard, Vincent^1,2, Fresneau, Brice³, le Fayech, Chiraz³, Haddy, Nadia^1,2, Rubino, Carole^1,2, Pacquement, Helène⁴, Veres, Cristina^1,2,5, Llanas, Damien^1,2, Diallo, Ibrahima^1,2, de Vathaire, Florent^1,2 florent.devathaire@gustaveroussy.fr, Pacquement, Helène⁴ (AUTHOR)
Source:	International Journal of Radiation Oncology, Biology, Physics. Nov2018, Vol. 102 Issue 3, p578-583. 6p.
Subjects:	Breast cancer in men, Childhood cancer, Radiotherapy, Progesterone receptors, Hormone receptor positive breast cancer, Breast tumors, Comparative studies, Longitudinal method, Research methodology, Medical cooperation, Medical screening, Radiation doses, Radiation carcinogenesis, Research, Sex distribution, Evaluation research, Male breast cancer, Secondary primary cancer
Geographic Terms:	France
Abstract:	Purpose: Male breast cancer (MBC) is uncommon, accounting for less than 1% of all breast cancers. Secondary breast cancers among childhood cancer survivors have been well described in the literature, but less is known about MBC.Methods and Materials: We carried out an analysis in a cohort of 7019 five-year survivors of a solid childhood (aged ≤20 years) cancer treated in France before 2001 and followed for an average of 20 years and compared breast cancers occurring in both men and women.Results: Among the 7019 survivors, 4 out of 3893 male survivors developed breast cancer, compared with 99 out of 3126 female survivors. All of the men had a history of radiation therapy. The 4 men with MBC had estrogen receptors and 3 had progesterone receptors.Conclusions: MBC is a rare second malignancy among childhood cancer survivors. Receipt of radiation therapy is a recognized risk factor, but more data about eventual genetic mutations are necessary. Regular screening based only on a history of radiation therapy is not recommended; however, attention must be given in the case of suspicious symptoms. [ABSTRACT FROM AUTHOR]
	Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Engineering Source

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