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Surface modification of polyurethane with a hydrophilic, antibacterial polymer for improved antifouling and antibacterial function.

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Title: Surface modification of polyurethane with a hydrophilic, antibacterial polymer for improved antifouling and antibacterial function.
Authors: Xie, Dong1 dxie@iupui.edu, Howard, Leah1, Almousa, Rashed1
Source: Journal of Biomaterials Applications. Sep2018, Vol. 33 Issue 3, p340-351. 12p.
Subjects: Polyurethanes, Polymers, Biocides, Antibacterial agents, Biofilms, Biomaterials
Abstract: Antimicrobial surface is important for the inhibition of bacteria or biofilm formation on biomaterials. The objective of this study was to immobilize a novel hydrophilic polymer containing the antibacterial moiety onto polyurethane surface via a simple surface coating technology to make the surface not only antibacterial but also antifouling. The compound 3,4-dichloro-5-hydroxy-2(5H)-furanone was derivatized, characterized and incorporated onto polyvinylpyrrolidone containing succinimidyl functional groups, followed by coating onto the polyurethane surface. Contact angle, antibacterial function and protein adsorption of the modified surface were evaluated. The result shows that the modified surface exhibited significantly enhanced hydrophilicity with a 54–65% decrease in contact angle, increased antibacterial activity to Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa with a 24–57% decrease in viability, and reduced human serum albumin adsorption with a 64–70% decrease in adsorption, as compared to the original polyurethane. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomaterials Applications is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 131906186
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Surface modification of polyurethane with a hydrophilic, antibacterial polymer for improved antifouling and antibacterial function.
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  Data: <searchLink fieldCode="AR" term="%22Xie%2C+Dong%22">Xie, Dong</searchLink><relatesTo>1</relatesTo><i> dxie@iupui.edu</i><br /><searchLink fieldCode="AR" term="%22Howard%2C+Leah%22">Howard, Leah</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Almousa%2C+Rashed%22">Almousa, Rashed</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomaterials+Applications%22">Journal of Biomaterials Applications</searchLink>. Sep2018, Vol. 33 Issue 3, p340-351. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Polyurethanes%22">Polyurethanes</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Biocides%22">Biocides</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Biofilms%22">Biofilms</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Antimicrobial surface is important for the inhibition of bacteria or biofilm formation on biomaterials. The objective of this study was to immobilize a novel hydrophilic polymer containing the antibacterial moiety onto polyurethane surface via a simple surface coating technology to make the surface not only antibacterial but also antifouling. The compound 3,4-dichloro-5-hydroxy-2(5H)-furanone was derivatized, characterized and incorporated onto polyvinylpyrrolidone containing succinimidyl functional groups, followed by coating onto the polyurethane surface. Contact angle, antibacterial function and protein adsorption of the modified surface were evaluated. The result shows that the modified surface exhibited significantly enhanced hydrophilicity with a 54–65% decrease in contact angle, increased antibacterial activity to Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa with a 24–57% decrease in viability, and reduced human serum albumin adsorption with a 64–70% decrease in adsorption, as compared to the original polyurethane. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomaterials Applications is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1177/0885328218792687
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 340
    Subjects:
      – SubjectFull: Polyurethanes
        Type: general
      – SubjectFull: Polymers
        Type: general
      – SubjectFull: Biocides
        Type: general
      – SubjectFull: Antibacterial agents
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      – SubjectFull: Biofilms
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      – SubjectFull: Biomaterials
        Type: general
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      – TitleFull: Surface modification of polyurethane with a hydrophilic, antibacterial polymer for improved antifouling and antibacterial function.
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            NameFull: Howard, Leah
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            – D: 01
              M: 09
              Text: Sep2018
              Type: published
              Y: 2018
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