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Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect.

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Title: Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect.
Authors: Choi, Yu Ri1, Kim, Hyun-Jong1,2, Ahn, Guk Young1, Lee, Min Jeong1, Park, Ju Ri1, Jun, Dae-Ryong1, Ryu, Tae-Kyoung1, Park, Joo Woong3, Shin, Eunji3, Choi, Sung-Wook1 choisw@catholic.ac.kr
Source: Colloids & Surfaces B: Biointerfaces. Nov2018, Vol. 171, p690-697. 8p.
Subjects: Hyaluronic acid, Nanogels, Organic acids, Nuclear magnetic resonance spectroscopy, Liquid chromatography, Crosslinking (Polymerization), Polymerization
Abstract: Graphical abstract Highlights • Hyaluronic acid molecules are conjugated among themselves in nanogel form. • Dihydroxyflavones are conjugated to hyaluronic acid nanogels. • A low concentration of a conjugation agent leads to the nanogel size reduction. • The nanogel specifically reduced the viability of tumor cells to approximately 60%. Abstract We prepared hyaluronic acid (HA)-based nanogels conjugated with dihydroxyflavone (DHF) and evaluated their cellular uptake and antitumoral efficiency. 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) was used as a conjugation agent for esterification between DHF and HA as well as crosslinking among HA. The conjugations were confirmed by nuclear magnetic resonance spectroscopy, UV/vis spectroscopy, and high-performance liquid chromatography. The size and Zeta-potential of the DHF/HA nanogels were reduced with an increase in the concentration of DMTMM due to the involvement of more HA molecules for the conjugation reactions. The DHF/HA nanogel with a smaller size was greatly taken up by two kinds of tumor cells (HeLa and HepG2), compared to NIH3T3. The cell viabilities were reduced to approximately 60% for HeLa and HepG2 cells after 48 h post treatment with DHF/HA nanogels. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 132148962
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  Data: Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect.
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  Data: <searchLink fieldCode="AR" term="%22Choi%2C+Yu+Ri%22">Choi, Yu Ri</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Hyun-Jong%22">Kim, Hyun-Jong</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ahn%2C+Guk+Young%22">Ahn, Guk Young</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Min+Jeong%22">Lee, Min Jeong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Ju+Ri%22">Park, Ju Ri</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jun%2C+Dae-Ryong%22">Jun, Dae-Ryong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ryu%2C+Tae-Kyoung%22">Ryu, Tae-Kyoung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Joo+Woong%22">Park, Joo Woong</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Shin%2C+Eunji%22">Shin, Eunji</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Choi%2C+Sung-Wook%22">Choi, Sung-Wook</searchLink><relatesTo>1</relatesTo><i> choisw@catholic.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Nov2018, Vol. 171, p690-697. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Hyaluronic+acid%22">Hyaluronic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Nanogels%22">Nanogels</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+acids%22">Organic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography%22">Liquid chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Crosslinking+%28Polymerization%29%22">Crosslinking (Polymerization)</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerization%22">Polymerization</searchLink>
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  Data: Graphical abstract Highlights • Hyaluronic acid molecules are conjugated among themselves in nanogel form. • Dihydroxyflavones are conjugated to hyaluronic acid nanogels. • A low concentration of a conjugation agent leads to the nanogel size reduction. • The nanogel specifically reduced the viability of tumor cells to approximately 60%. Abstract We prepared hyaluronic acid (HA)-based nanogels conjugated with dihydroxyflavone (DHF) and evaluated their cellular uptake and antitumoral efficiency. 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) was used as a conjugation agent for esterification between DHF and HA as well as crosslinking among HA. The conjugations were confirmed by nuclear magnetic resonance spectroscopy, UV/vis spectroscopy, and high-performance liquid chromatography. The size and Zeta-potential of the DHF/HA nanogels were reduced with an increase in the concentration of DMTMM due to the involvement of more HA molecules for the conjugation reactions. The DHF/HA nanogel with a smaller size was greatly taken up by two kinds of tumor cells (HeLa and HepG2), compared to NIH3T3. The cell viabilities were reduced to approximately 60% for HeLa and HepG2 cells after 48 h post treatment with DHF/HA nanogels. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.colsurfb.2018.08.003
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 690
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      – SubjectFull: Hyaluronic acid
        Type: general
      – SubjectFull: Nanogels
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      – SubjectFull: Organic acids
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      – SubjectFull: Nuclear magnetic resonance spectroscopy
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      – SubjectFull: Liquid chromatography
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      – SubjectFull: Crosslinking (Polymerization)
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      – SubjectFull: Polymerization
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      – TitleFull: Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect.
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              Text: Nov2018
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