Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis.
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| Title: | Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis. |
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| Authors: | Hu, Ying-Jie1 yingjie.hu93@gmail.com, Zhang, Jing-Ying1, Luo, Qian1, Xu, Jia-Rui1, Yan, Yan1, Mu, Li-Min1, Bai, Jing1, Lu, Wan-Liang1 luwl@bjmu.edu.cn |
| Source: | Nanomaterials (2079-4991). Oct2018, Vol. 8 Issue 10, p804. 1p. |
| Subjects: | Artemisinin, Breast cancer treatment, Apoptosis |
| Abstract: | The heterogeneity of breast cancer and the development of drug resistance are the relapse reasons of disease after chemotherapy. To address this issue, a combined therapeutic strategy was developed by building the nanostructured dihydroartemisinin plus epirubicin liposomes. Investigations were performed on human breast cancer cells in vitro and xenografts in nude mice. The results indicated that dihydroartemisinin could significantly enhance the efficacy of epirubicin in killing different breast cancer cells in vitro and in vivo. We found that the combined use of dihydroartemisinin with epirubicin could efficiently inhibit the activity of Bcl-2, facilitate release of Beclin 1, and further activate Bax. Besides, Bax activated apoptosis which led to the type I programmed death of breast cancer cells while Beclin 1 initiated the excessive autophagy that resulted in the type II programmed death of breast cancer cells. In addition, the nanostructured dihydroartemisinin plus epirubicin liposomes prolonged circulation of drugs, and were beneficial for simultaneously delivering drugs into breast cancer tissues. Hence, the nanostructured dihydroartemisinin plus epirubicin liposomes could provide a new therapeutic strategy for treatment of breast cancer. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 132633204 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hu%2C+Ying-Jie%22">Hu, Ying-Jie</searchLink><relatesTo>1</relatesTo><i> yingjie.hu93@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing-Ying%22">Zhang, Jing-Ying</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Luo%2C+Qian%22">Luo, Qian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Jia-Rui%22">Xu, Jia-Rui</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yan%2C+Yan%22">Yan, Yan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mu%2C+Li-Min%22">Mu, Li-Min</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bai%2C+Jing%22">Bai, Jing</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lu%2C+Wan-Liang%22">Lu, Wan-Liang</searchLink><relatesTo>1</relatesTo><i> luwl@bjmu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Oct2018, Vol. 8 Issue 10, p804. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Artemisinin%22">Artemisinin</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer+treatment%22">Breast cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The heterogeneity of breast cancer and the development of drug resistance are the relapse reasons of disease after chemotherapy. To address this issue, a combined therapeutic strategy was developed by building the nanostructured dihydroartemisinin plus epirubicin liposomes. Investigations were performed on human breast cancer cells in vitro and xenografts in nude mice. The results indicated that dihydroartemisinin could significantly enhance the efficacy of epirubicin in killing different breast cancer cells in vitro and in vivo. We found that the combined use of dihydroartemisinin with epirubicin could efficiently inhibit the activity of Bcl-2, facilitate release of Beclin 1, and further activate Bax. Besides, Bax activated apoptosis which led to the type I programmed death of breast cancer cells while Beclin 1 initiated the excessive autophagy that resulted in the type II programmed death of breast cancer cells. In addition, the nanostructured dihydroartemisinin plus epirubicin liposomes prolonged circulation of drugs, and were beneficial for simultaneously delivering drugs into breast cancer tissues. Hence, the nanostructured dihydroartemisinin plus epirubicin liposomes could provide a new therapeutic strategy for treatment of breast cancer. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano8100804 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 804 Subjects: – SubjectFull: Artemisinin Type: general – SubjectFull: Breast cancer treatment Type: general – SubjectFull: Apoptosis Type: general Titles: – TitleFull: Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hu, Ying-Jie – PersonEntity: Name: NameFull: Zhang, Jing-Ying – PersonEntity: Name: NameFull: Luo, Qian – PersonEntity: Name: NameFull: Xu, Jia-Rui – PersonEntity: Name: NameFull: Yan, Yan – PersonEntity: Name: NameFull: Mu, Li-Min – PersonEntity: Name: NameFull: Bai, Jing – PersonEntity: Name: NameFull: Lu, Wan-Liang IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 8 – Type: issue Value: 10 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
