Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial.
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| Title: | Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial. |
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| Authors: | Langella, Luciana Gonçalves1,2, Casalechi, Heliodora Leão1, Tomazoni, Shaiane Silva3, Johnson, Douglas Scott4, Albertini, Regiane5, Pallotta, Rodney Capp6, Marcos, Rodrigo Labat6, de Carvalho, Paulo de Tarso Camillo2,6, Leal-Junior, Ernesto Cesar Pinto1,2 ernesto.leal.junior@gmail.com |
| Source: | Lasers in Medical Science. Dec2018, Vol. 33 Issue 9, p1933-1940. 8p. |
| Subjects: | Osteoarthritis, Quality of life, Arthritis, Total hip replacement, Clinical trials |
| Abstract: | When conservative treatments fail, hip osteoarthritis (OA), a chronic degenerative disease characterized by cartilage wear, progressive joint deformity, and loss of function, can result in the need for a total hip arthroplasty (THA). Surgical procedures induced tissue trauma and incite an immune response. Photobiomodulation therapy (PBMt) using low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) has proven effective in tissue repair by modulating the inflammatory process and promoting pain relief. Therefore, the aim of this study was to analyze the immediate effect of PBMt on inflammation and pain of patients undergoing total hip arthroplasty. The study consisted of 18 post-surgical hip arthroplasty patients divided into two groups (n = 9 each) placebo and active PBMt who received one of the treatments in a period from 8 to 12 h following THA surgery. PBMt (active or placebo) was applied using a device consisting of nine diodes (one super-pulsed laser of 905 nm, four infrared LEDs of 875 nm, and four red LEDs 640 nm, 40.3 J per point) applied to 5 points along the incision. Visual analog scale (VAS) and blood samples for analysis of the levels of the cytokines TNF-α, IL-6, and IL-8 were recorded before and after PBMt application. The values for the visual analog scale as well as those in the analysis of TNF-α and IL-8 serum levels decreased in the active PBMt group compared to placebo-control group (p < 0.05). No decrease was observed for IL-6 levels. We conclude that PBMt is effective in decreasing pain intensity and post-surgery inflammation in patients receiving total hip arthroplasty. [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Langella%2C+Luciana+Gonçalves%22">Langella, Luciana Gonçalves</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Casalechi%2C+Heliodora+Leão%22">Casalechi, Heliodora Leão</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tomazoni%2C+Shaiane+Silva%22">Tomazoni, Shaiane Silva</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Johnson%2C+Douglas+Scott%22">Johnson, Douglas Scott</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Albertini%2C+Regiane%22">Albertini, Regiane</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Pallotta%2C+Rodney+Capp%22">Pallotta, Rodney Capp</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Marcos%2C+Rodrigo+Labat%22">Marcos, Rodrigo Labat</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Carvalho%2C+Paulo+de+Tarso+Camillo%22">de Carvalho, Paulo de Tarso Camillo</searchLink><relatesTo>2,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Leal-Junior%2C+Ernesto+Cesar+Pinto%22">Leal-Junior, Ernesto Cesar Pinto</searchLink><relatesTo>1,2</relatesTo><i> ernesto.leal.junior@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. Dec2018, Vol. 33 Issue 9, p1933-1940. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Osteoarthritis%22">Osteoarthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Arthritis%22">Arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Total+hip+replacement%22">Total hip replacement</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: When conservative treatments fail, hip osteoarthritis (OA), a chronic degenerative disease characterized by cartilage wear, progressive joint deformity, and loss of function, can result in the need for a total hip arthroplasty (THA). Surgical procedures induced tissue trauma and incite an immune response. Photobiomodulation therapy (PBMt) using low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) has proven effective in tissue repair by modulating the inflammatory process and promoting pain relief. Therefore, the aim of this study was to analyze the immediate effect of PBMt on inflammation and pain of patients undergoing total hip arthroplasty. The study consisted of 18 post-surgical hip arthroplasty patients divided into two groups (n = 9 each) placebo and active PBMt who received one of the treatments in a period from 8 to 12 h following THA surgery. PBMt (active or placebo) was applied using a device consisting of nine diodes (one super-pulsed laser of 905 nm, four infrared LEDs of 875 nm, and four red LEDs 640 nm, 40.3 J per point) applied to 5 points along the incision. Visual analog scale (VAS) and blood samples for analysis of the levels of the cytokines TNF-α, IL-6, and IL-8 were recorded before and after PBMt application. The values for the visual analog scale as well as those in the analysis of TNF-α and IL-8 serum levels decreased in the active PBMt group compared to placebo-control group (p < 0.05). No decrease was observed for IL-6 levels. We conclude that PBMt is effective in decreasing pain intensity and post-surgery inflammation in patients receiving total hip arthroplasty. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-018-2558-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1933 Subjects: – SubjectFull: Osteoarthritis Type: general – SubjectFull: Quality of life Type: general – SubjectFull: Arthritis Type: general – SubjectFull: Total hip replacement Type: general – SubjectFull: Clinical trials Type: general Titles: – TitleFull: Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Langella, Luciana Gonçalves – PersonEntity: Name: NameFull: Casalechi, Heliodora Leão – PersonEntity: Name: NameFull: Tomazoni, Shaiane Silva – PersonEntity: Name: NameFull: Johnson, Douglas Scott – PersonEntity: Name: NameFull: Albertini, Regiane – PersonEntity: Name: NameFull: Pallotta, Rodney Capp – PersonEntity: Name: NameFull: Marcos, Rodrigo Labat – PersonEntity: Name: NameFull: de Carvalho, Paulo de Tarso Camillo – PersonEntity: Name: NameFull: Leal-Junior, Ernesto Cesar Pinto IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 33 – Type: issue Value: 9 Titles: – TitleFull: Lasers in Medical Science Type: main |
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