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Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release.

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Title: Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release.
Authors: Labie, Hélène1, Perro, Adeline1, Lapeyre, Véronique1, Goudeau, Bertrand1, Catargi, Bogdan1, Auzély, Rachel1, Ravaine, Valérie1 vravaine@enscbp.fr
Source: Journal of Colloid & Interface Science. Feb2019, Vol. 535, p16-27. 12p.
Subjects: Hyaluronic acid, Microgels, Polypeptides, Hydrophilic compounds, Crosslinking (Polymerization)
Abstract: Graphical abstract Abstract A simple route to deliver on demand hydrosoluble molecules such as peptides, packaged in biocompatible and biodegradable microgels, is presented. Hyaluronic acid hydrogel particles with a controlled structure are prepared using a microfluidic approach. Their porosity and their rigidity can be tuned by changing the crosslinking density. These negatively-charged polyelectrolytes interact strongly with positively-charged linear peptides such as poly- l -lysine (PLL). Their interactions induce microgel deswelling and inhibit microgel enzymatic degradability by hyaluronidase. While small PLL penetrate the whole volume of the microgel, PLL larger than the mesh size of the network remain confined at its periphery. They make a complexed layer with reduced pore size, which insulates the microgel inner core from the outer medium. Consequently, enzymatic degradation of the matrix is fully inhibited and non-affinity hydrophilic species can be trapped in the core. Indeed, negatively-charged or small neutral peptides, without interactions with the network, usually diffuse freely across the network. By simple addition of large PLL, they are packaged in the core and can be released on demand, upon introduction of an enzyme that degrades selectively the capping agent. Single polyelectrolyte layer appears as a simple generic method to coat hydrogel-based materials of various scales for encapsulation and controlled delivery of hydrosoluble molecules. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 133045160
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release.
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  Data: <searchLink fieldCode="AR" term="%22Labie%2C+Hélène%22">Labie, Hélène</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Perro%2C+Adeline%22">Perro, Adeline</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lapeyre%2C+Véronique%22">Lapeyre, Véronique</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Goudeau%2C+Bertrand%22">Goudeau, Bertrand</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Catargi%2C+Bogdan%22">Catargi, Bogdan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Auzély%2C+Rachel%22">Auzély, Rachel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ravaine%2C+Valérie%22">Ravaine, Valérie</searchLink><relatesTo>1</relatesTo><i> vravaine@enscbp.fr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Colloid+%26+Interface+Science%22">Journal of Colloid & Interface Science</searchLink>. Feb2019, Vol. 535, p16-27. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Hyaluronic+acid%22">Hyaluronic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Microgels%22">Microgels</searchLink><br /><searchLink fieldCode="DE" term="%22Polypeptides%22">Polypeptides</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrophilic+compounds%22">Hydrophilic compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Crosslinking+%28Polymerization%29%22">Crosslinking (Polymerization)</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Graphical abstract Abstract A simple route to deliver on demand hydrosoluble molecules such as peptides, packaged in biocompatible and biodegradable microgels, is presented. Hyaluronic acid hydrogel particles with a controlled structure are prepared using a microfluidic approach. Their porosity and their rigidity can be tuned by changing the crosslinking density. These negatively-charged polyelectrolytes interact strongly with positively-charged linear peptides such as poly- l -lysine (PLL). Their interactions induce microgel deswelling and inhibit microgel enzymatic degradability by hyaluronidase. While small PLL penetrate the whole volume of the microgel, PLL larger than the mesh size of the network remain confined at its periphery. They make a complexed layer with reduced pore size, which insulates the microgel inner core from the outer medium. Consequently, enzymatic degradation of the matrix is fully inhibited and non-affinity hydrophilic species can be trapped in the core. Indeed, negatively-charged or small neutral peptides, without interactions with the network, usually diffuse freely across the network. By simple addition of large PLL, they are packaged in the core and can be released on demand, upon introduction of an enzyme that degrades selectively the capping agent. Single polyelectrolyte layer appears as a simple generic method to coat hydrogel-based materials of various scales for encapsulation and controlled delivery of hydrosoluble molecules. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.jcis.2018.09.048
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 16
    Subjects:
      – SubjectFull: Hyaluronic acid
        Type: general
      – SubjectFull: Microgels
        Type: general
      – SubjectFull: Polypeptides
        Type: general
      – SubjectFull: Hydrophilic compounds
        Type: general
      – SubjectFull: Crosslinking (Polymerization)
        Type: general
    Titles:
      – TitleFull: Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release.
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            NameFull: Labie, Hélène
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            NameFull: Perro, Adeline
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            NameFull: Lapeyre, Véronique
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            NameFull: Goudeau, Bertrand
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            NameFull: Catargi, Bogdan
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            NameFull: Auzély, Rachel
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              M: 02
              Text: Feb2019
              Type: published
              Y: 2019
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              Value: 00219797
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              Value: 535
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            – TitleFull: Journal of Colloid & Interface Science
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