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Characterization of cord blood interleukin 10 on aflatoxinB1-exposed patients with gestational diabetes.

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Title: Characterization of cord blood interleukin 10 on aflatoxinB1-exposed patients with gestational diabetes.
Authors: Xie, Guojie1, Liu, Manjun1, Xia, Chunbo1, Li, Rong1 lirong1278@163.com
Source: Clinica Chimica Acta. Dec2018, Vol. 487, p46-47. 2p.
Subjects: Cord blood, Gestational diabetes, Interleukin-10, Aflatoxins, Carcinogenesis, Immunoregulation
Abstract: Abstract Background Interleukin 10 (IL10) refers to a pleiotropic cytokine exerted immunoregulation. Aflatoxin B1 (AFB1) is a strong carcinogen, marked by causing immunosuppression. We determined the possible association between cord blood IL10 and AFB1-exposed patients with gestational diabetes (GD). Methods Cord blood samples from non-GD adults (n = 3) and GD patients (n = 3) were harvested for determining representative serological parameters by use of biochemical assays and enzyme linked immunosorbent assay (ELISA) tests. Results As results, GD patients showed no statistical comparable clinical data (hepatic function, lipids metabolism, immune cell count) to those in controls or references. Interestingly, cord blood contents of AFB1 in GD patients were significantly increased when compared to those in non-GD controls, characterized with visibly increased cord blood IL10. Conclusions Preliminary clinical data reveal that IL10 may function as a biomarker for immunoregulation in AFB1-exposed GD patients. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Abstract Background Interleukin 10 (IL10) refers to a pleiotropic cytokine exerted immunoregulation. Aflatoxin B1 (AFB1) is a strong carcinogen, marked by causing immunosuppression. We determined the possible association between cord blood IL10 and AFB1-exposed patients with gestational diabetes (GD). Methods Cord blood samples from non-GD adults (n = 3) and GD patients (n = 3) were harvested for determining representative serological parameters by use of biochemical assays and enzyme linked immunosorbent assay (ELISA) tests. Results As results, GD patients showed no statistical comparable clinical data (hepatic function, lipids metabolism, immune cell count) to those in controls or references. Interestingly, cord blood contents of AFB1 in GD patients were significantly increased when compared to those in non-GD controls, characterized with visibly increased cord blood IL10. Conclusions Preliminary clinical data reveal that IL10 may function as a biomarker for immunoregulation in AFB1-exposed GD patients. [ABSTRACT FROM AUTHOR]
ISSN:00098981
DOI:10.1016/j.cca.2018.09.025