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Characterization of cord blood interleukin 10 on aflatoxinB1-exposed patients with gestational diabetes.

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Title: Characterization of cord blood interleukin 10 on aflatoxinB1-exposed patients with gestational diabetes.
Authors: Xie, Guojie1, Liu, Manjun1, Xia, Chunbo1, Li, Rong1 lirong1278@163.com
Source: Clinica Chimica Acta. Dec2018, Vol. 487, p46-47. 2p.
Subjects: Cord blood, Gestational diabetes, Interleukin-10, Aflatoxins, Carcinogenesis, Immunoregulation
Abstract: Abstract Background Interleukin 10 (IL10) refers to a pleiotropic cytokine exerted immunoregulation. Aflatoxin B1 (AFB1) is a strong carcinogen, marked by causing immunosuppression. We determined the possible association between cord blood IL10 and AFB1-exposed patients with gestational diabetes (GD). Methods Cord blood samples from non-GD adults (n = 3) and GD patients (n = 3) were harvested for determining representative serological parameters by use of biochemical assays and enzyme linked immunosorbent assay (ELISA) tests. Results As results, GD patients showed no statistical comparable clinical data (hepatic function, lipids metabolism, immune cell count) to those in controls or references. Interestingly, cord blood contents of AFB1 in GD patients were significantly increased when compared to those in non-GD controls, characterized with visibly increased cord blood IL10. Conclusions Preliminary clinical data reveal that IL10 may function as a biomarker for immunoregulation in AFB1-exposed GD patients. [ABSTRACT FROM AUTHOR]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 133067759
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  Data: Characterization of cord blood interleukin 10 on aflatoxinB1-exposed patients with gestational diabetes.
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  Data: <searchLink fieldCode="AR" term="%22Xie%2C+Guojie%22">Xie, Guojie</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liu%2C+Manjun%22">Liu, Manjun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xia%2C+Chunbo%22">Xia, Chunbo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Li%2C+Rong%22">Li, Rong</searchLink><relatesTo>1</relatesTo><i> lirong1278@163.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Clinica+Chimica+Acta%22">Clinica Chimica Acta</searchLink>. Dec2018, Vol. 487, p46-47. 2p.
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  Data: <searchLink fieldCode="DE" term="%22Cord+blood%22">Cord blood</searchLink><br /><searchLink fieldCode="DE" term="%22Gestational+diabetes%22">Gestational diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-10%22">Interleukin-10</searchLink><br /><searchLink fieldCode="DE" term="%22Aflatoxins%22">Aflatoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract Background Interleukin 10 (IL10) refers to a pleiotropic cytokine exerted immunoregulation. Aflatoxin B1 (AFB1) is a strong carcinogen, marked by causing immunosuppression. We determined the possible association between cord blood IL10 and AFB1-exposed patients with gestational diabetes (GD). Methods Cord blood samples from non-GD adults (n = 3) and GD patients (n = 3) were harvested for determining representative serological parameters by use of biochemical assays and enzyme linked immunosorbent assay (ELISA) tests. Results As results, GD patients showed no statistical comparable clinical data (hepatic function, lipids metabolism, immune cell count) to those in controls or references. Interestingly, cord blood contents of AFB1 in GD patients were significantly increased when compared to those in non-GD controls, characterized with visibly increased cord blood IL10. Conclusions Preliminary clinical data reveal that IL10 may function as a biomarker for immunoregulation in AFB1-exposed GD patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.cca.2018.09.025
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      – Code: eng
        Text: English
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        PageCount: 2
        StartPage: 46
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      – SubjectFull: Cord blood
        Type: general
      – SubjectFull: Gestational diabetes
        Type: general
      – SubjectFull: Interleukin-10
        Type: general
      – SubjectFull: Aflatoxins
        Type: general
      – SubjectFull: Carcinogenesis
        Type: general
      – SubjectFull: Immunoregulation
        Type: general
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      – TitleFull: Characterization of cord blood interleukin 10 on aflatoxinB1-exposed patients with gestational diabetes.
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            NameFull: Li, Rong
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              M: 12
              Text: Dec2018
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              Y: 2018
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