View in EDS HTML Full Text PDF Full Text

Dynamic contrast-enhanced CT for the assessment of tumour response in malignant pleural mesothelioma: a pilot study.

Saved in:
Bibliographic Details
Title: Dynamic contrast-enhanced CT for the assessment of tumour response in malignant pleural mesothelioma: a pilot study.
Authors: Gudmundsson, Eyjolfur1 egudmundsson@uchicago.edu, Labby, Zacariah1,2, Straus, Christopher M.1, Sensakovic, William F.1,3, Li, Feng1, Rose, Buerkley4, Cunliffe, Alexandra1,5, Kindler, Hedy L.4, Armato, Samuel G.1, Armato, Samuel G 3rd6 (AUTHOR)
Source: European Radiology. Feb2019, Vol. 29 Issue 2, p682-688. 7p. 3 Charts, 2 Graphs, 1 Map.
Subjects: Computed tomography, Mesothelioma, Medical protocols, Cancer chemotherapy, Cancer treatment
Abstract: Objectives: The aim of this pilot study was to investigate the utility of haemodynamic parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT) scans in the assessment of tumour response to treatment in malignant pleural mesothelioma (MPM) patients.Methods: The patient cohort included nine patients undergoing chemotherapy and five patients on observation. Each patient underwent two DCE-CT scans separated by approximately 2 months. The DCE-CT parameters of tissue blood flow (BF) and tissue blood volume (BV) were obtained within the dynamically imaged tumour. Mean relative changes in tumour DCE-CT parameters between scans were compared between the on-treatment and on-observation cohorts. DCE-CT parameter changes were correlated with relative change in tumour bulk evaluated according to the modified RECIST protocol.Results: Differing trends in relative change in BF and BV between scans were found between the two patient groups (p = 0.19 and p = 0.06 for BF and BV, respectively). No significant rank correlations were found when comparing relative changes in DCE-CT parameters with relative change in tumour bulk.Conclusions: Differing trends in the relative change of BF and BV between patients on treatment and on observation indicate the potential of DCE-CT for the assessment of pharmacodynamic endpoints with respect to treatment in MPM. A future study with a larger patient cohort and unified treatment regimens should be undertaken to confirm the results of this pilot study.Key Points: • CT-derived haemodynamic parameters show differing trends between malignant pleural mesothelioma patients on treatment and patients off treatment • Changes in haemodynamic parameters do not correlate with changes in tumour bulk as measured according to the modified RECIST protocol • Differing trends across the two patient groups indicate the potential sensitivity of DCE-CT to assess pharmacodynamic endpoints in the treatment of MPM. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 133695290
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Dynamic contrast-enhanced CT for the assessment of tumour response in malignant pleural mesothelioma: a pilot study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Gudmundsson%2C+Eyjolfur%22">Gudmundsson, Eyjolfur</searchLink><relatesTo>1</relatesTo><i> egudmundsson@uchicago.edu</i><br /><searchLink fieldCode="AR" term="%22Labby%2C+Zacariah%22">Labby, Zacariah</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Straus%2C+Christopher+M%2E%22">Straus, Christopher M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sensakovic%2C+William+F%2E%22">Sensakovic, William F.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Li%2C+Feng%22">Li, Feng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rose%2C+Buerkley%22">Rose, Buerkley</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cunliffe%2C+Alexandra%22">Cunliffe, Alexandra</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Kindler%2C+Hedy+L%2E%22">Kindler, Hedy L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Armato%2C+Samuel+G%2E%22">Armato, Samuel G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Armato%2C+Samuel+G+3rd%22">Armato, Samuel G 3rd</searchLink><relatesTo>6</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Feb2019, Vol. 29 Issue 2, p682-688. 7p. 3 Charts, 2 Graphs, 1 Map.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Mesothelioma%22">Mesothelioma</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+protocols%22">Medical protocols</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+chemotherapy%22">Cancer chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Objectives: </bold>The aim of this pilot study was to investigate the utility of haemodynamic parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT) scans in the assessment of tumour response to treatment in malignant pleural mesothelioma (MPM) patients.<bold>Methods: </bold>The patient cohort included nine patients undergoing chemotherapy and five patients on observation. Each patient underwent two DCE-CT scans separated by approximately 2 months. The DCE-CT parameters of tissue blood flow (BF) and tissue blood volume (BV) were obtained within the dynamically imaged tumour. Mean relative changes in tumour DCE-CT parameters between scans were compared between the on-treatment and on-observation cohorts. DCE-CT parameter changes were correlated with relative change in tumour bulk evaluated according to the modified RECIST protocol.<bold>Results: </bold>Differing trends in relative change in BF and BV between scans were found between the two patient groups (p = 0.19 and p = 0.06 for BF and BV, respectively). No significant rank correlations were found when comparing relative changes in DCE-CT parameters with relative change in tumour bulk.<bold>Conclusions: </bold>Differing trends in the relative change of BF and BV between patients on treatment and on observation indicate the potential of DCE-CT for the assessment of pharmacodynamic endpoints with respect to treatment in MPM. A future study with a larger patient cohort and unified treatment regimens should be undertaken to confirm the results of this pilot study.<bold>Key Points: </bold>• CT-derived haemodynamic parameters show differing trends between malignant pleural mesothelioma patients on treatment and patients off treatment • Changes in haemodynamic parameters do not correlate with changes in tumour bulk as measured according to the modified RECIST protocol • Differing trends across the two patient groups indicate the potential sensitivity of DCE-CT to assess pharmacodynamic endpoints in the treatment of MPM. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=133695290
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00330-018-5533-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 682
    Subjects:
      – SubjectFull: Computed tomography
        Type: general
      – SubjectFull: Mesothelioma
        Type: general
      – SubjectFull: Medical protocols
        Type: general
      – SubjectFull: Cancer chemotherapy
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
    Titles:
      – TitleFull: Dynamic contrast-enhanced CT for the assessment of tumour response in malignant pleural mesothelioma: a pilot study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gudmundsson, Eyjolfur
      – PersonEntity:
          Name:
            NameFull: Labby, Zacariah
      – PersonEntity:
          Name:
            NameFull: Straus, Christopher M.
      – PersonEntity:
          Name:
            NameFull: Sensakovic, William F.
      – PersonEntity:
          Name:
            NameFull: Li, Feng
      – PersonEntity:
          Name:
            NameFull: Rose, Buerkley
      – PersonEntity:
          Name:
            NameFull: Cunliffe, Alexandra
      – PersonEntity:
          Name:
            NameFull: Kindler, Hedy L.
      – PersonEntity:
          Name:
            NameFull: Armato, Samuel G.
      – PersonEntity:
          Name:
            NameFull: Armato, Samuel G 3rd
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 09387994
          Numbering:
            – Type: volume
              Value: 29
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Radiology
              Type: main
ResultId 1