Functionalized nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell decorated imprinted polymer for electrochemical sensing of anticancerous hydroxyurea.
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| Title: | Functionalized nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell decorated imprinted polymer for electrochemical sensing of anticancerous hydroxyurea. |
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| Authors: | Pathak, Purnendu Kumar1, Kumar, Anil1, Prasad, Bhim Bali1 prof.bbpd@yahoo.com |
| Source: | Biosensors & Bioelectronics. Feb2019, Vol. 127, p10-18. 9p. |
| Subjects: | Electrochemistry, Hydroxyurea, Antineoplastic agents, Quantum dots, Molecular imprinting |
| Abstract: | Abstract A novel molecularly imprinted polymer-capped acrylated nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell was synthesized to serve as a sensing nano-hybrid film for the detection of an anticancerous drug, hydroxyurea. This exploited the use of a functionalized nitrogen doped graphene quantum dots iniferter. This initiated the polymerization, following "surface grafting-from" approach, over the surface of a screen-printed carbon electrode to obtain requisite stability and selectivity of the measurement. Herein, nitrogen doped graphene quantum dots were prepared utilizing the degree of dehydration/carbonization of citric acid (carbon skeleton) and urea (nitrogen dopant) as source materials. This provided an efficient sensor platform anchoring bimetallic Au/Ag core-shell on its surface. The nano-assembly of acrylated nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell@imprinted polymer actually amplified the electrode kinetics by improving the diffusion coefficient (~20-fold) and electron-transfer kinetics (~5-fold), in comparison to the simple bimetallic Au/Ag core-shell decorated imprinted sensor. Under optimized conditions of differential pulse anodic stripping voltammetric transduction, a linear relationship between the current and the concentration was obtained in the range of 0.62–102.33 ng mL−1 for hydroxyurea. The detection limit was observed to be 0.07 ng mL−1 in blood plasma, without having any matrix effect, cross-reactivity, and false-positives. The proposed sensor assures its clinical applicability for the treatment of cancer. Highlights • Nanocomposite of nitrogen doped quantum dots@Au/Ag and imprinted polymer was fabricated. • As prepared nanocomposite acted as an effective electron mediator. • Functionalized nitrogen doped graphene quantum dots used as an iniferter. • Detection sensitivity was realized to be 0.05 ng mL-1 with imprinting factor 18.6. [ABSTRACT FROM AUTHOR] |
| Copyright of Biosensors & Bioelectronics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 134048583 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functionalized nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell decorated imprinted polymer for electrochemical sensing of anticancerous hydroxyurea. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pathak%2C+Purnendu+Kumar%22">Pathak, Purnendu Kumar</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kumar%2C+Anil%22">Kumar, Anil</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Prasad%2C+Bhim+Bali%22">Prasad, Bhim Bali</searchLink><relatesTo>1</relatesTo><i> prof.bbpd@yahoo.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biosensors+%26+Bioelectronics%22">Biosensors & Bioelectronics</searchLink>. Feb2019, Vol. 127, p10-18. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Electrochemistry%22">Electrochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyurea%22">Hydroxyurea</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Quantum+dots%22">Quantum dots</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+imprinting%22">Molecular imprinting</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract A novel molecularly imprinted polymer-capped acrylated nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell was synthesized to serve as a sensing nano-hybrid film for the detection of an anticancerous drug, hydroxyurea. This exploited the use of a functionalized nitrogen doped graphene quantum dots iniferter. This initiated the polymerization, following "surface grafting-from" approach, over the surface of a screen-printed carbon electrode to obtain requisite stability and selectivity of the measurement. Herein, nitrogen doped graphene quantum dots were prepared utilizing the degree of dehydration/carbonization of citric acid (carbon skeleton) and urea (nitrogen dopant) as source materials. This provided an efficient sensor platform anchoring bimetallic Au/Ag core-shell on its surface. The nano-assembly of acrylated nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell@imprinted polymer actually amplified the electrode kinetics by improving the diffusion coefficient (~20-fold) and electron-transfer kinetics (~5-fold), in comparison to the simple bimetallic Au/Ag core-shell decorated imprinted sensor. Under optimized conditions of differential pulse anodic stripping voltammetric transduction, a linear relationship between the current and the concentration was obtained in the range of 0.62–102.33 ng mL−1 for hydroxyurea. The detection limit was observed to be 0.07 ng mL−1 in blood plasma, without having any matrix effect, cross-reactivity, and false-positives. The proposed sensor assures its clinical applicability for the treatment of cancer. Highlights • Nanocomposite of nitrogen doped quantum dots@Au/Ag and imprinted polymer was fabricated. • As prepared nanocomposite acted as an effective electron mediator. • Functionalized nitrogen doped graphene quantum dots used as an iniferter. • Detection sensitivity was realized to be 0.05 ng mL-1 with imprinting factor 18.6. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biosensors & Bioelectronics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bios.2018.11.055 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 10 Subjects: – SubjectFull: Electrochemistry Type: general – SubjectFull: Hydroxyurea Type: general – SubjectFull: Antineoplastic agents Type: general – SubjectFull: Quantum dots Type: general – SubjectFull: Molecular imprinting Type: general Titles: – TitleFull: Functionalized nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell decorated imprinted polymer for electrochemical sensing of anticancerous hydroxyurea. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pathak, Purnendu Kumar – PersonEntity: Name: NameFull: Kumar, Anil – PersonEntity: Name: NameFull: Prasad, Bhim Bali IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 02 Text: Feb2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 09565663 Numbering: – Type: volume Value: 127 Titles: – TitleFull: Biosensors & Bioelectronics Type: main |
| ResultId | 1 |
