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Influence of tumor-associated macrophages and HLA class I expression according to HPV status in head and neck cancer patients receiving chemo/bioradiotherapy.

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Title: Influence of tumor-associated macrophages and HLA class I expression according to HPV status in head and neck cancer patients receiving chemo/bioradiotherapy.
Authors: Ou, Dan1 (AUTHOR), Adam, Julien1 (AUTHOR), Garberis, Ingrid1 (AUTHOR), Blanchard, Pierre1 (AUTHOR), Nguyen, France1 (AUTHOR), Levy, Antonin1 (AUTHOR), Casiraghi, Odile1 (AUTHOR), Gorphe, Philippe1 (AUTHOR), Breuskin, Ingrid1 (AUTHOR), Janot, François1 (AUTHOR), Temam, Stephane1 (AUTHOR), Scoazec, Jean-Yves1 (AUTHOR), Deutsch, Eric1 (AUTHOR), Tao, Yungan1 (AUTHOR) yungan.tao@gustaveroussy.fr
Source: Radiotherapy & Oncology. Jan2019, Vol. 130, p89-96. 8p.
Subjects: Head & neck cancer, Cancer patients, Subgroup analysis (Experimental design), Squamous cell carcinoma
Abstract: Highlights • Intraepithelial macrophage density was associated with favorable progression-free survival. • HLA class I down-regulation was not an independent prognostic factor. • Stromal M2 density may potentially be used to guide treatment selection. Abstract Background and purpose To investigate the prognostic value of tumor-associated macrophages (TAM) and HLA class I expression according to HPV status in patients with head and neck squamous cell carcinoma treated with definitive radiotherapy combining cisplatin (CRT) or cetuximab (BRT). Material and methods Ninety-five patients were enrolled. The density of CD68+ cells and CD68+ CD163+ cells (further referred as M2) in the intraepithelial and the stromal compartments, respectively, as well as HLA class I expression in tumor cells, were evaluated semi-quantitatively. Correlations between biomarker expression and treatment outcomes were analyzed. Results Multivariate analysis showed that the intraepithelial macrophage density (IEMD) was prognostic for favorable progression-free survival (PFS) and there was a non-significant trend for improved overall survival (OS). HLA class I down-regulation was not an independent prognostic factor. Subgroup analysis showed that in p16+ population, patients with high IEMD had improved 5-year PFS vs. patients with low IEMD (81.2% vs. 25.0%, p < 0.001), while in p16− population, no difference was observed. Similarly, when stratified by primary tumor site, IEMD showed prognostic value in oropharyngeal cancer patients (OPC) but not non-OPC patients. Five-year PFS of patients with low stromal M2 macrophage density treated with CRT was significantly improved vs. those with BRT (54.5% vs. 36.1%, p = 0.03), while in tumors with high M2, there was no significant difference (50.3% vs. 42.9%, p = 0.67). Conclusions The prognostic role of TAM phenotype and distribution depends on HPV status and might predict treatment response. They prompt further validation in prospective studies. [ABSTRACT FROM AUTHOR]
Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Influence of tumor-associated macrophages and HLA class I expression according to HPV status in head and neck cancer patients receiving chemo/bioradiotherapy.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ou%2C+Dan%22&quot;&gt;Ou, Dan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Adam%2C+Julien%22&quot;&gt;Adam, Julien&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Garberis%2C+Ingrid%22&quot;&gt;Garberis, Ingrid&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Blanchard%2C+Pierre%22&quot;&gt;Blanchard, Pierre&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nguyen%2C+France%22&quot;&gt;Nguyen, France&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Levy%2C+Antonin%22&quot;&gt;Levy, Antonin&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Casiraghi%2C+Odile%22&quot;&gt;Casiraghi, Odile&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gorphe%2C+Philippe%22&quot;&gt;Gorphe, Philippe&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Breuskin%2C+Ingrid%22&quot;&gt;Breuskin, Ingrid&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Janot%2C+Fran&#231;ois%22&quot;&gt;Janot, Fran&#231;ois&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Temam%2C+Stephane%22&quot;&gt;Temam, Stephane&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Scoazec%2C+Jean-Yves%22&quot;&gt;Scoazec, Jean-Yves&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Deutsch%2C+Eric%22&quot;&gt;Deutsch, Eric&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tao%2C+Yungan%22&quot;&gt;Tao, Yungan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; yungan.tao@gustaveroussy.fr&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Radiotherapy+%26+Oncology%22&quot;&gt;Radiotherapy &amp; Oncology&lt;/searchLink&gt;. Jan2019, Vol. 130, p89-96. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Head+%26+neck+cancer%22&quot;&gt;Head &amp; neck cancer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cancer+patients%22&quot;&gt;Cancer patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Subgroup+analysis+%28Experimental+design%29%22&quot;&gt;Subgroup analysis (Experimental design)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Squamous+cell+carcinoma%22&quot;&gt;Squamous cell carcinoma&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Highlights • Intraepithelial macrophage density was associated with favorable progression-free survival. • HLA class I down-regulation was not an independent prognostic factor. • Stromal M2 density may potentially be used to guide treatment selection. Abstract Background and purpose To investigate the prognostic value of tumor-associated macrophages (TAM) and HLA class I expression according to HPV status in patients with head and neck squamous cell carcinoma treated with definitive radiotherapy combining cisplatin (CRT) or cetuximab (BRT). Material and methods Ninety-five patients were enrolled. The density of CD68+ cells and CD68+ CD163+ cells (further referred as M2) in the intraepithelial and the stromal compartments, respectively, as well as HLA class I expression in tumor cells, were evaluated semi-quantitatively. Correlations between biomarker expression and treatment outcomes were analyzed. Results Multivariate analysis showed that the intraepithelial macrophage density (IEMD) was prognostic for favorable progression-free survival (PFS) and there was a non-significant trend for improved overall survival (OS). HLA class I down-regulation was not an independent prognostic factor. Subgroup analysis showed that in p16+ population, patients with high IEMD had improved 5-year PFS vs. patients with low IEMD (81.2% vs. 25.0%, p &lt; 0.001), while in p16− population, no difference was observed. Similarly, when stratified by primary tumor site, IEMD showed prognostic value in oropharyngeal cancer patients (OPC) but not non-OPC patients. Five-year PFS of patients with low stromal M2 macrophage density treated with CRT was significantly improved vs. those with BRT (54.5% vs. 36.1%, p = 0.03), while in tumors with high M2, there was no significant difference (50.3% vs. 42.9%, p = 0.67). Conclusions The prognostic role of TAM phenotype and distribution depends on HPV status and might predict treatment response. They prompt further validation in prospective studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Radiotherapy &amp; Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.radonc.2018.08.013
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      – Code: eng
        Text: English
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        PageCount: 8
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      – SubjectFull: Head & neck cancer
        Type: general
      – SubjectFull: Cancer patients
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      – SubjectFull: Subgroup analysis (Experimental design)
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      – SubjectFull: Squamous cell carcinoma
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              Text: Jan2019
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