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Gemcitabine and betulinic acid co-encapsulated PLGA−PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.

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Title: Gemcitabine and betulinic acid co-encapsulated PLGA−PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.
Authors: Saneja, Ankit1, Kumar, Robin1, Mintoo, Mubashir J.1, Dubey, Ravindra Dhar1, Sangwan, Payare Lal1, Mondhe, Dilip M.1 dmmondhe@iiim.ac.in, Panda, Amulya K.1 amulya@nii.res.in, Gupta, Prem N.1 pngupta@iiim.ac.in
Source: Materials Science & Engineering: C. May2019, Vol. 98, p764-771. 8p.
Subjects: Cancer chemotherapy, Polylactic acid, Nanomedicine, Antineoplastic agents, Transmission electron microscopy
Abstract: Abstract The present study demonstrated the development of gemcitabine and betulinic acid co-encapsulated PLGA−PEG polymer nanoparticles for enhancing the chemotherapeutic response. This combinatorial PLGA-PEG nanoparticle was formulated using double emulsion and had size <200 nm. The developed nanoparticles were characterized using dynamic light scattering and transmission electron microscopy for their size and shape, respectively. The in vitro release of the drugs from combinatorial nanoparticles was predominantly followed by Fickian diffusion phenomenon. Study on hemocompatibilty approved the administration of this combinatorial nanoparticle for animal study. In vitro cytotoxicity study on Panc1 cells using MTT assay, reactive oxygen species production and cellular apoptotic assay demonstrated that combinatorial nanoparticle was more cytotoxic compared to native drugs solution. Furthermore, the combinatorial nanoparticle suppressed tumor growth more efficiently in Ehrlich (solid) tumor model than the native gemcitabine and betulinic acid at the same concentrations. These findings indicated that PLGA-PEG nanoparticle might be used to co-deliver multiple chemotherapeutic drugs with different properties for enhancing antitumor efficacy. Highlights • Development of gemcitabine and betulinic acid loaded PLGA−PEG nanoparticles. • Combinatorial nanoparticle was more cytotoxic compared to native drugs. • Mechanistic investigation was performed using ROS and apoptotic assay in PANC1 cells. • Combinatorial nanoparticle exhibited improved anti-tumor efficacy in solid tumor model. [ABSTRACT FROM AUTHOR]
Copyright of Materials Science & Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 134883306
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PubTypeId: academicJournal
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  Data: Gemcitabine and betulinic acid co-encapsulated PLGA−PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saneja%2C+Ankit%22&quot;&gt;Saneja, Ankit&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kumar%2C+Robin%22&quot;&gt;Kumar, Robin&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mintoo%2C+Mubashir+J%2E%22&quot;&gt;Mintoo, Mubashir J.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dubey%2C+Ravindra+Dhar%22&quot;&gt;Dubey, Ravindra Dhar&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sangwan%2C+Payare+Lal%22&quot;&gt;Sangwan, Payare Lal&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mondhe%2C+Dilip+M%2E%22&quot;&gt;Mondhe, Dilip M.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; dmmondhe@iiim.ac.in&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Panda%2C+Amulya+K%2E%22&quot;&gt;Panda, Amulya K.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; amulya@nii.res.in&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gupta%2C+Prem+N%2E%22&quot;&gt;Gupta, Prem N.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; pngupta@iiim.ac.in&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Materials+Science+%26+Engineering%3A+C%22&quot;&gt;Materials Science &amp; Engineering: C&lt;/searchLink&gt;. May2019, Vol. 98, p764-771. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cancer+chemotherapy%22&quot;&gt;Cancer chemotherapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Polylactic+acid%22&quot;&gt;Polylactic acid&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nanomedicine%22&quot;&gt;Nanomedicine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antineoplastic+agents%22&quot;&gt;Antineoplastic agents&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Transmission+electron+microscopy%22&quot;&gt;Transmission electron microscopy&lt;/searchLink&gt;
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  Data: Abstract The present study demonstrated the development of gemcitabine and betulinic acid co-encapsulated PLGA−PEG polymer nanoparticles for enhancing the chemotherapeutic response. This combinatorial PLGA-PEG nanoparticle was formulated using double emulsion and had size &lt;200 nm. The developed nanoparticles were characterized using dynamic light scattering and transmission electron microscopy for their size and shape, respectively. The in vitro release of the drugs from combinatorial nanoparticles was predominantly followed by Fickian diffusion phenomenon. Study on hemocompatibilty approved the administration of this combinatorial nanoparticle for animal study. In vitro cytotoxicity study on Panc1 cells using MTT assay, reactive oxygen species production and cellular apoptotic assay demonstrated that combinatorial nanoparticle was more cytotoxic compared to native drugs solution. Furthermore, the combinatorial nanoparticle suppressed tumor growth more efficiently in Ehrlich (solid) tumor model than the native gemcitabine and betulinic acid at the same concentrations. These findings indicated that PLGA-PEG nanoparticle might be used to co-deliver multiple chemotherapeutic drugs with different properties for enhancing antitumor efficacy. Highlights • Development of gemcitabine and betulinic acid loaded PLGA−PEG nanoparticles. • Combinatorial nanoparticle was more cytotoxic compared to native drugs. • Mechanistic investigation was performed using ROS and apoptotic assay in PANC1 cells. • Combinatorial nanoparticle exhibited improved anti-tumor efficacy in solid tumor model. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Materials Science &amp; Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.msec.2019.01.026
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      – Code: eng
        Text: English
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        PageCount: 8
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    Subjects:
      – SubjectFull: Cancer chemotherapy
        Type: general
      – SubjectFull: Polylactic acid
        Type: general
      – SubjectFull: Nanomedicine
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      – SubjectFull: Antineoplastic agents
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      – SubjectFull: Transmission electron microscopy
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      – TitleFull: Gemcitabine and betulinic acid co-encapsulated PLGA−PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.
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              Text: May2019
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              Value: 98
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