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Biosynthesis of 1,4-butanediol from erythritol using whole-cell catalysis.

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Title: Biosynthesis of 1,4-butanediol from erythritol using whole-cell catalysis.
Authors: Dai, Lu1,2, Tai, Cui2, Shen, Yaling1 ylshen@ecust.edu.cn, Guo, Yali1,2, Tao, Fei2 taofei@sjtu.edu.cn
Source: Biocatalysis & Biotransformation. Apr2019, Vol. 37 Issue 2, p92-96. 5p. 5 Graphs.
Subjects: Butanediol, Biosynthesis, Biocatalysis, Low temperatures, Bioconversion, Erythritol
Abstract: 1,4-Butanediol (BDO) biosynthesis from renewable resources is of increasing interest because of global energy and environmental problems. We have previously demonstrated the production of BDO from erythritol by whole-cell catalysis. Here, the effects of several variables on BDO production were investigated, including cell density, temperature, substrate concentration and pH. It was found that the maximum BDO production was obtained at cell density (OD600) of 30. Low temperature and weak alkaline environment were beneficial for the biotransformation. Regarding substrate concentration, 80 g/L of erythritol was found to be optimum for the bioconversion. Under the optimal conditions, the highest concentration of BDO reached 34.5 mg/L, resulting in 5.8-fold increment after optimization. These results will provide useful guidance for enhancing the bioconversion of erythritol to BDO. [ABSTRACT FROM AUTHOR]
Copyright of Biocatalysis & Biotransformation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Biosynthesis of 1,4-butanediol from erythritol using whole-cell catalysis.
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  Data: <searchLink fieldCode="AR" term="%22Dai%2C+Lu%22">Dai, Lu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tai%2C+Cui%22">Tai, Cui</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Shen%2C+Yaling%22">Shen, Yaling</searchLink><relatesTo>1</relatesTo><i> ylshen@ecust.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Guo%2C+Yali%22">Guo, Yali</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tao%2C+Fei%22">Tao, Fei</searchLink><relatesTo>2</relatesTo><i> taofei@sjtu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Biocatalysis+%26+Biotransformation%22">Biocatalysis & Biotransformation</searchLink>. Apr2019, Vol. 37 Issue 2, p92-96. 5p. 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Butanediol%22">Butanediol</searchLink><br /><searchLink fieldCode="DE" term="%22Biosynthesis%22">Biosynthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Biocatalysis%22">Biocatalysis</searchLink><br /><searchLink fieldCode="DE" term="%22Low+temperatures%22">Low temperatures</searchLink><br /><searchLink fieldCode="DE" term="%22Bioconversion%22">Bioconversion</searchLink><br /><searchLink fieldCode="DE" term="%22Erythritol%22">Erythritol</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: 1,4-Butanediol (BDO) biosynthesis from renewable resources is of increasing interest because of global energy and environmental problems. We have previously demonstrated the production of BDO from erythritol by whole-cell catalysis. Here, the effects of several variables on BDO production were investigated, including cell density, temperature, substrate concentration and pH. It was found that the maximum BDO production was obtained at cell density (OD600) of 30. Low temperature and weak alkaline environment were beneficial for the biotransformation. Regarding substrate concentration, 80 g/L of erythritol was found to be optimum for the bioconversion. Under the optimal conditions, the highest concentration of BDO reached 34.5 mg/L, resulting in 5.8-fold increment after optimization. These results will provide useful guidance for enhancing the bioconversion of erythritol to BDO. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biocatalysis & Biotransformation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/10242422.2018.1465414
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 5
        StartPage: 92
    Subjects:
      – SubjectFull: Butanediol
        Type: general
      – SubjectFull: Biosynthesis
        Type: general
      – SubjectFull: Biocatalysis
        Type: general
      – SubjectFull: Low temperatures
        Type: general
      – SubjectFull: Bioconversion
        Type: general
      – SubjectFull: Erythritol
        Type: general
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      – TitleFull: Biosynthesis of 1,4-butanediol from erythritol using whole-cell catalysis.
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            NameFull: Dai, Lu
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            NameFull: Tai, Cui
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            NameFull: Shen, Yaling
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            NameFull: Guo, Yali
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            NameFull: Tao, Fei
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              M: 04
              Text: Apr2019
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              Y: 2019
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