View in EDS

Advances in the metabolic engineering of Yarrowia lipolytica for the production of terpenoids.

Saved in:
Bibliographic Details
Title: Advances in the metabolic engineering of Yarrowia lipolytica for the production of terpenoids.
Authors: Ma, Yi-Rong1 (AUTHOR), Wang, Kai-Feng1 (AUTHOR), Wang, Wei-Jian1 (AUTHOR), Ding, Ying1 (AUTHOR), Shi, Tian-Qiong1 (AUTHOR), Huang, He1 (AUTHOR), Ji, Xiao-Jun1 (AUTHOR) xiaojunji@njtech.edu.cn
Source: Bioresource Technology. Jun2019, Vol. 281, p449-456. 8p.
Subjects: Terpenes, Microbiological synthesis, Engineering
Abstract: Highlights • Y. lipolytica is a promising chassis for the production of plant derived terpenoids. • Metabolic engineering strategies for terpenoids synthesis in Y. lipolytica are summarized. • Prospective for terpenoids synthesis in Y. lipolytica based on latest technology are discussed. Abstract Terpenoids are a large class of natural compounds based on the C5 isoprene unit, with many biological effects such activity against cancer and allergies, while some also have an agreeable aroma. Consequently, they have received extensive attention in the food, pharmaceutical and cosmetic fields. With the identification and analysis of the underlying natural product synthesis pathways, current microbial-based metabolic engineering approaches have yielded new strategies for the production of highly valuable terpenoids. Yarrowia lipolytica is a non-conventional oleaginous yeast that is rapidly emerging as a valuable host for the production of terpenoids due to its own endogenous mevalonate pathway and high oil production capacity. This review aims to summarize the status and strategies of metabolic engineering for the heterologous synthesis of terpenoids in Y. lipolytica in recent years and proposes new methods aiming towards further improvement of terpenoid production. [ABSTRACT FROM AUTHOR]
Copyright of Bioresource Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 135377360
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Advances in the metabolic engineering of Yarrowia lipolytica for the production of terpenoids.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ma%2C+Yi-Rong%22">Ma, Yi-Rong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Kai-Feng%22">Wang, Kai-Feng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Wei-Jian%22">Wang, Wei-Jian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ding%2C+Ying%22">Ding, Ying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Tian-Qiong%22">Shi, Tian-Qiong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+He%22">Huang, He</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ji%2C+Xiao-Jun%22">Ji, Xiao-Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> xiaojunji@njtech.edu.cn</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Bioresource+Technology%22">Bioresource Technology</searchLink>. Jun2019, Vol. 281, p449-456. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Terpenes%22">Terpenes</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiological+synthesis%22">Microbiological synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Engineering%22">Engineering</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Highlights • Y. lipolytica is a promising chassis for the production of plant derived terpenoids. • Metabolic engineering strategies for terpenoids synthesis in Y. lipolytica are summarized. • Prospective for terpenoids synthesis in Y. lipolytica based on latest technology are discussed. Abstract Terpenoids are a large class of natural compounds based on the C5 isoprene unit, with many biological effects such activity against cancer and allergies, while some also have an agreeable aroma. Consequently, they have received extensive attention in the food, pharmaceutical and cosmetic fields. With the identification and analysis of the underlying natural product synthesis pathways, current microbial-based metabolic engineering approaches have yielded new strategies for the production of highly valuable terpenoids. Yarrowia lipolytica is a non-conventional oleaginous yeast that is rapidly emerging as a valuable host for the production of terpenoids due to its own endogenous mevalonate pathway and high oil production capacity. This review aims to summarize the status and strategies of metabolic engineering for the heterologous synthesis of terpenoids in Y. lipolytica in recent years and proposes new methods aiming towards further improvement of terpenoid production. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Bioresource Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=135377360
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.biortech.2019.02.116
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 449
    Subjects:
      – SubjectFull: Terpenes
        Type: general
      – SubjectFull: Microbiological synthesis
        Type: general
      – SubjectFull: Engineering
        Type: general
    Titles:
      – TitleFull: Advances in the metabolic engineering of Yarrowia lipolytica for the production of terpenoids.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ma, Yi-Rong
      – PersonEntity:
          Name:
            NameFull: Wang, Kai-Feng
      – PersonEntity:
          Name:
            NameFull: Wang, Wei-Jian
      – PersonEntity:
          Name:
            NameFull: Ding, Ying
      – PersonEntity:
          Name:
            NameFull: Shi, Tian-Qiong
      – PersonEntity:
          Name:
            NameFull: Huang, He
      – PersonEntity:
          Name:
            NameFull: Ji, Xiao-Jun
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 09608524
          Numbering:
            – Type: volume
              Value: 281
          Titles:
            – TitleFull: Bioresource Technology
              Type: main
ResultId 1